Clinical Evaluation of <i>Viscum album</i> Mother Tincture as an Antihypertensive

Poruthukaren, Kurian John; Palatty, Princy Louis; Baliga, Manjeshwar Shrinath; Suresh, Sucharita

doi:10.1177/2156587213507726

Cited by 33 publications

(28 citation statements)

References 17 publications

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“…In addition, antihypercholesterolaemic effects are demonstrated ( 17 ). Moreover, recent clinical trials have demonstrated the favorable effects of V. album on hypertension ( 18 ). Reduction in the cyclophosphamide-induced cardiotoxicity via administration of V. album was reported by Şekeroğlu et al ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

“…V. album has also been extensively studied in cardiovascular research, especially in the field of hypertension, and favorable effects have been identified. The reduction in both systolic and diastolic blood pressure was attributed to a mechanism involving upregulation in the nitric oxide (NO) pathway ( 5 ). The association between V. album and NO has been supported by other clinical and experimental studies ( 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

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Cardioprotective effects of Viscum album L. ssp. album (Loranthaceae) on isoproterenol-induced heart failure via regulation of the nitric oxide pathway in rats

et al. 2016

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Objective:Viscum album L. has favorable cardiovascular effects including antihypertensive and vasorelaxant activity, and the nitric oxide (NO) pathway upregulation has been proposed to be the underlying mechanism. NO also plays an important role in the pathophysiology of heart failure. However, its effects on cardiac systolic function are unclear.Methods:A total of 30 male Wistar albino rats at 12 weeks of age were randomly divided into three groups: control, isoproterenol-induced heart failure group (ISO), and isoproterenol-induced heart failure + V. album treatment group (VA) groups (n=10 in each group). V. album was orally given at a dose of 250 mg/kg/day by gavage. Parameters of heart failure were compared among the groups. Tamhane’s T2 test, paired sample t-test, and Bonferroni methods were used for statistical analysis.Results:V. album resulted in an improvement in all parameters of heart failure including left ventricular diameters (6.34±0.23 mm, 6.98±0.35 mm, and 6.71±0.10 mm for left ventricular end-diastolic diameter in control, ISO, and VA groups, respectively, p<0.05), ejection fraction (73.3±3.1%, 56.7±2.6%, and 65.2±1.5% for control, ISO, and VA groups, respectively, p<0.05), serum NT-proBNP levels, and histopathological changes. V. album treatment resulted in a statistically significant attenuation of increased levels of NO and iNOS (p<0.0001). The levels of hs-CRP were also found to be lower in the VA group compared with the controls and ISO groups (p<0.01).Conclusion:V. album exerted favorable effects on left ventricular function in isoproterenol-induced heart failure rats. Upregulation of the NO pathway seems to be the possible pathophysiological mechanism. Favorable vascular outcomes can also be speculated considering the reduction in serum hs-CRP levels.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cardioprotective effects of Viscum album L. ssp. album (Loranthaceae) on isoproterenol-induced heart failure via regulation of the nitric oxide pathway in rats

et al. 2016

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“…48 More commonly, mistletoe is reported to have a hypotensive effect and has even been used in the treatment of hypertension. [49][50][51] Nevertheless, the suspected ADR may have been related to IT injection of a high mistletoe dose or was possibly a result of suboptimal hypertension treatment preintervention or insufficient pain management postintervention.…”

Section: Figurementioning

confidence: 99%

Use and Safety of Intratumoral Application of European Mistletoe (Viscum album L) Preparations in Oncology

et al. 2014

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Background. Intratumoral (IT) injection of European mistletoe (Viscum album L) preparations might induce local tumor response through combined cytotoxic and immunomodulatory actions of the preparations. Although promising in vitro and in vivo data, along with clinical case studies suggest the need for validation of this hypothesis in prospective trials, the safety of IT mistletoe injections has yet to be thoroughly assessed. Methods. The present study summarizes the practice and safety of off-label IT mistletoe therapy within the Network Oncology, a conjoint clinical registry of German hospitals and outpatients specialized in anthroposophic and integrative medicine. Demographic, diagnosis and treatment data of cancer patients who received IT mistletoe applications between 2007 and 2013 were assessed. Suspected adverse drug reactions (ADRs) were analyzed in terms of type, frequency, severity, seriousness and potential risk factors. Results. A total of 123 cancer patients received 862 IT mistletoe injections (preparations from Abnoba, Helixor and Iscucin).The most commonly applied preparations were Abnoba viscum Fraxini (71 patients) and Helixor Mali (54 patients). Of the total patients, 26 patients (21.1%) experienced 74 ADRs. All ADRs were in response to either Abnoba viscum Fraxini (25.4% of exposed patients) or Helixor Mali (18.5% of exposed patients). ADRs were mostly body temperature or immune related and of mild (83.8%) or moderate (14.9%) intensity. Only one possible ADR was described as severe (hypertension) and no serious ADRs occurred. The frequency of ADRs to IT mistletoe injections was 3 times and 5 times higher than has previously been found for subcutaneous and intravenous applications of mistletoe, respectively. Conclusion. IT injection of mistletoe preparations resulted in a relatively high frequency of ADRs. Nearly all ADRs were mild to moderate however, and no serious ADRs occurred. Furthermore, it is possible that immune-related ADRs such as pyrexia and local inflammatory reactions might be critical for tumor response. In light of these results, IT mistletoe therapy seems to be safe and prospective trials are recommended.

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“…Clinical studies supports the antihypertensive effects of garlic (Allium sativum L.) (Ashraf et al 2013), hawthorn (Crataegus sp.) (Chang et al 2012), mistletoe (Viscum album L.) (Poruthukaren et al 2014), stinging nettle (Urtica dioica L.) (Qayyum er al. 2016) and olive (Somova et al 2003).…”

Section: Resultsmentioning

confidence: 99%

Medicinal Plants Used In Traditional Treatment of Hypertension in Turkey

2020

JSTR

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Since ancient times people have used plants because of their therapeutic effects. People have recorded the therapeutic effects of plants throughout history. Turkey has a rich traditional medicine and ethnobotanical culture. People have preserved this ethnobotanical culture by transferring them from generation to generation. Medicinal plants are playing an important role in health care programmes worldwide, especially in developing countries. In Turkey there are many plant species known with their blood pressure lowering effect. In this study 150 plant taxa, used against hypertension in Turkey were compiled. The study contains botanical names, families, local names, used parts and method of use of these plant species. According to this research commonly used medicinal plants are from Rosaceae (27 taxa), Lamiaceae (26 taxa), Asteraceae (15 taxa), Apiaceae (11 taxa), Polygonaceae (6 taxa), Loranthaceae (3 taxa) and Rhamnaceae (3 taxa) respectively.

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Clinical Evaluation of Viscum album Mother Tincture as an Antihypertensive

Cited by 33 publications

References 17 publications

Cardioprotective effects of Viscum album L. ssp. album (Loranthaceae) on isoproterenol-induced heart failure via regulation of the nitric oxide pathway in rats

Cardioprotective effects of Viscum album L. ssp. album (Loranthaceae) on isoproterenol-induced heart failure via regulation of the nitric oxide pathway in rats

Use and Safety of Intratumoral Application of European Mistletoe (Viscum album L) Preparations in Oncology

Medicinal Plants Used In Traditional Treatment of Hypertension in Turkey

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