Clinical evaluation of language fundamentals in Rolandic epilepsy, an assessment with CELF-4

Overvliet, Geke M.; Besseling, René M.H.; Kruijs, Sylvie J.M. van der; Vles, Johan S.H.; Backes, Walter H.; Hendriksen, Jos G.M.; Ebus, Saskia C.M.; Jansen, Jacobus F. A.; Hofman, Paul; Aldenkamp, Albert P.

doi:10.1016/j.ejpn.2013.01.001

Cited by 45 publications

(37 citation statements)

References 24 publications

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“…(Camfield and Camfield, 2014) However, there is growing evidence that points toward a less benign nature of this epilepsy syndrome in which affected children exhibit a variety of cognitive impairments (Danielsson and Petermann, 2009) linked largely but not exclusively to language function. (Datta et al, 2013; Overvliet et al, 2011b; Overvliet et al, 2013) Here we found that, compared to HC, new-onset drug-naïve BECTS patients exhibited increased ReHo while chronic BECTS on medication exhibited decreased ReHo in bilateral sensorimotor regions including the rolandic cortex, the putative source for abnormal epileptiform activity in BECTS. This result suggests that antiepileptic drugs (AEDs) may reverse this abnormal activity observed in the new-onset drug-naïve BECTS and even reach a lower level when compared with HC.…”

Section: Discussionmentioning

confidence: 62%

Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTS): A resting state fMRI study

et al. 2015

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Objective The purpose of this study was to investigate regional homogeneity (ReHo) in children with new-onset drug-naïve Benign Epilepsy with Centrotemporal Spikes (BECTS), chronic BECTS and healthy controls (HC) using the Regional Homogeneity (ReHo) method applied to resting state fMRI data. Methods Resting state fMRI data was collected from three groups of children aged 6 to13, including new onset drug naïve BECTS, chronic BECTS with medication, and HC; the data analyzed by ReHo method. Mandarin school exams scores were acquired and compared across groups. Results There were three main findings. Firstly, compared with HC, abnormally increased ReHo was observed in bilateral sensorimotor regions in new onset BECTS which normalized or even reversed in the chronic BECTS group. Secondly, enhanced ReHo was found in the left frontal language region in the two BECTS groups, with even higher ReHo value in the chronic group. Lastly, decreased ReHo was found in regions of the default mode network (DMN), bilateral occipital lobes and cerebellum in both the new onset and chronic BECTS groups, lower in chronic BECTS. Behavioral analyses of school scores showed the chronic BECTS group presented significantly lower scores compared to HC (p < .05). Significance The coherence of low frequency fluctuations is disrupted in sensorimotor, language and DMN-related regions in new-onset BECTS. Some of these effects seem to be selectively normalized in chronic BECTS, thus allowing us to explore possible chronicity and AED-induced effects on BECTS. Abnormal ReHo in left language and DMN regions could be responsible for impairments of cognitive function.

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Section: Discussionmentioning

confidence: 62%

Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTS): A resting state fMRI study

et al. 2015

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“…On the one hand, it is considered that the lesions caused by the manifestations of epileptic seizures are on a developing brain (Overvliet et al, 2013, Smith et al, 2012, suggesting that the reading difficulties presented by children with RE are directly associated with the amount of nocturnal epileptiform activity (Gobbi, Boni, & Filippini, 2006). On the other, there is the occurrence of overlapping cortical areas of language with epileptic activity in the central region, namely the rolandic and Sylvian regions (Fonseca et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…This is because this area is considered to be the main weakness in the cognitive functions of this clinical subgroup, which is possibly associated to the harm caused by epilepsy crises on a developing brain (Aquino, Montenegro, Guerreiro & Guerreiro, 2005;Flax et al, 2003;Overvliet et al, 2013;Smith et al, 2012), especially on the areas of the brain related to language: the center of the brain, predominantly in the lower portion of the rolandic and Sylvian areas (Fonseca, Tedrus, Chiodi, Cerqueira & Duran, 2004;Hommet et al, 2001;Staden, Isaaca, Boyd, Brandl &, 1998;Xiao et al, 2016;Zaninotto & Hamad, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Despite the favorable prognosis, studies began to question the "benign" nature of this syndrome when faced with complaints about learning abilities and deficits in neuropsychological tests of children affected by the issue (Beaumanoir, Ballis, Varfis, & Ansari, 1974;Hermann, Jones, Jackson, & Seidenberg, 2012), especially in the areas of language, memory, attention, motor coordination and executive functions (Capelatto et al, 2012;Hwang et al, 2013;Kim, Lee, Chung, Lim & Lee, 2014;Miziara et al, 2012;Neri et al, 2012;Northcott et al, 2005;Overvliet et al, 2013;Smith et al, 2012;Smith, Bajomo, & Pal, 2015;Tovia et al, 2011;Vannest et al, 2013;Verrotti, Filippini, Matricardi, Agostinelli & Gobbi, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Working memory and phonological awareness in children with rolandic epilepsy

et al. 2017

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This study investigated how the difficulties in language in children with Rolandic Epilepsy (RE) could be related to alterations in their development of phonological awareness and/or working memory. We evaluated fourty-two children aged 6 to 13 years old. From these, twenty-one children were diagnosed with RE and formed the experimental group; and twenty-one children without RE, paired with the experimental group by sex, age, education and socioeconomic status, formed the control group. The results showed significant differences in the performances of children with RE and healthy children in the tests that evaluated working memory and phonological awareness. Also, positive and high significant correlations were found between working memory and phonological awareness in the RE clinical subgroup. Generally, the results suggest that compromises in both cognitive functions might be associated to loss of language capabilities in children with RE, and also point that the development of working memory and phonological awareness are interconnected.

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“…The Clinical Evaluation of Language Fundamentals (CELF-4) test for children, Dutch edition (Paslawski, 2005; Semel et al, 2010), was used to assess language performance (Overvliet et al, 2013). The central outcome measure of the CELF test is the core language score, which can serve as a screening measure for language impairment.…”

Section: Methodsmentioning

confidence: 99%

Spatial heterogeneity analysis of brain activation in fMRI

Gupta¹,

Besseling²,

Overvliet³

et al. 2014

NeuroImage: Clinical

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In many brain diseases it can be qualitatively observed that spatial patterns in blood oxygenation level dependent (BOLD) activation maps appear more (diffusively) distributed than in healthy controls. However, measures that can quantitatively characterize this spatial distributiveness in individual subjects are lacking. In this study, we propose a number of spatial heterogeneity measures to characterize brain activation maps. The proposed methods focus on different aspects of heterogeneity, including the shape (compactness), complexity in the distribution of activated regions (fractal dimension and co-occurrence matrix), and gappiness between activated regions (lacunarity). To this end, functional MRI derived activation maps of a language and a motor task were obtained in language impaired children with (Rolandic) epilepsy and compared to age-matched healthy controls. Group analysis of the activation maps revealed no significant differences between patients and controls for both tasks. However, for the language task the activation maps in patients appeared more heterogeneous than in controls. Lacunarity was the best measure to discriminate activation patterns of patients from controls (sensitivity 74%, specificity 70%) and illustrates the increased irregularity of gaps between activated regions in patients. The combination of heterogeneity measures and a support vector machine approach yielded further increase in sensitivity and specificity to 78% and 80%, respectively. This illustrates that activation distributions in impaired brains can be complex and more heterogeneous than in normal brains and cannot be captured fully by a single quantity. In conclusion, heterogeneity analysis has potential to robustly characterize the increased distributiveness of brain activation in individual patients.

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Clinical evaluation of language fundamentals in Rolandic epilepsy, an assessment with CELF-4

Cited by 45 publications

References 24 publications

Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTS): A resting state fMRI study

Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTS): A resting state fMRI study

Working memory and phonological awareness in children with rolandic epilepsy

Spatial heterogeneity analysis of brain activation in fMRI

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