Clinical evaluation of Libyan patients with rosacea and its correlation with seropositivity to Helicobacter pylori

Elsherif, Nadia Abdalhafid; El-Dibany, Salwa Abdalsalam

doi:10.1016/j.jssdds.2013.12.005

Cited by 4 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pooled proportions of ETR, PPR, PhR, and ocular rosacea among 9190 patients with rosacea, based on 39 studies (eTable 2 in the Supplement), were ETR: 56.7% (95% CI, 51.4%-62.0%; I 2 , 95.9%) (Figure 2), PPR: 43.2% (95% CI, 38.8%-47.6%; I 2 , 94.0%) (Figure 3), PhR: 7.4% (95% CI, 6.1%-8.9%; I 2 , 81.4%) (Figure 4), and ocular rosacea: 11.1% (95% CI, 6.7%-16.3%, I 2 , 98.1%) (Figure 5). The proportions of ETR and PPR appeared to be similar for male and female patients; the proportion of ETR was 58.3% (95% CI, 25.8%-87.2%) for men and 65.5% (95% CI, 41.8%-85.8%) for women based on 3 studies . Papulopustular rosacea was reported for 29.6% (95% CI, 10.5%-53.4%) of men and 34.6% (95% CI, 13.7%-59.3%) of women.…”

Section: Resultsmentioning

confidence: 99%

Assessment of Frequency of Rosacea Subtypes in Patients With Rosacea

et al. 2022

View full text Add to dashboard Cite

IMPORTANCEFour distinct rosacea subtypes have traditionally been recognized, but the frequency of these subtypes among patients with rosacea remains unknown.OBJECTIVE To assess the frequency of 4 rosacea subtypes.DATA SOURCES This systemic review and meta-analysis included a search of 2 databases, PubMed and Embase, from inception of the databases to November 2, 2021. The search was filtered to include only studies of human participants published in English, French, and German.STUDY SELECTION Studies were screened independently by 2 of the authors and were included if they were original with a sample size of 25 or more patients and reported absolute numbers or frequency of patients affected by rosacea subtypes. Studies that did not report sufficient data to calculate the proportions of subtypes were excluded. DATA EXTRACTION AND SYNTHESISData extraction was performed independently and in duplicate by 2 of the authors, using the search term rosacea, according to the Preferred Reporting items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The search term, objectives, and study protocol methods were defined before the study was initiated. A total of 292 studies were included for full-text assessment. Owing to the heterogeneity of the included studies, a random-effects model was used. MAIN OUTCOME AND MEASURESThe main outcome was the proportion of patients with rosacea in each of the 4 major subtype groups defined by the 2002 National Rosacea Society classification system. Measures were absolute numbers or frequency of patients affected by each of the 4 rosacea subtypes.RESULTS A total of 39 studies examining 9190 patients with rosacea were included. The pooled proportion of erythematotelangiectatic rosacea was 56.7% (95% CI, 51.4%-62.0%), of papulopustular rosacea was 43.2% (95% CI, 38.8%-47.6%), of phymatous rosacea was 7.4% (95% CI, 6.1%-8.9%), and of ocular rosacea was 11.1% (95% CI, 6.7%-16.3%). Subtype distribution occurred equally among men and women except for phymatous rosacea, which was more prevalent in men. Studies from Africa showed the lowest proportion of erythematotelangiectatic rosacea. Differences in frequency of subtypes were observed when stratification by publication year was performed. CONCLUSION AND RELEVANCEIn this systematic review and meta-analysis, differences were found in rosacea subtypes by patient sex and by continent of origin and publication year of included studies. Erythematotelangiectatic and papulopustular rosacea were the most prevalent subtypes, but data should be interpreted with caution. Future studies should use the phenotype-based rosacea approach.

show abstract

Section: Resultsmentioning

confidence: 99%

Assessment of Frequency of Rosacea Subtypes in Patients With Rosacea

et al. 2022

View full text Add to dashboard Cite

show abstract

“…And also, inconclusive evidence suggests that there is a possible association of Helicobacter pylori with the aetiology of rosacea 26 . However, many of the studies have not controlled for confounding variables that influence H. pylori prevalence, such as age, socioeconomic status, sex and certain medications 27 , 66 . Furthermore, these studies were not statistically significant to account for the ubiquitous nature of H pylori and also demodex infection.…”

Section: Resultsmentioning

confidence: 99%

Major Pathophysiological Correlations of Rosacea: A Complete Clinical Appraisal

Vemuri¹,

Gundamaraju²,

Sekaran³

et al. 2015

Int. J. Med. Sci.

View full text Add to dashboard Cite

Background: Rosacea is a characteristic cutaneous disorder with a diverse clinical manifestations ranging from facial vascular hyper-reactivity to sebaceous gland hyperplasia. Many theories on pathophysiology of rosacea were proposed over the past decade, however the pathogenicity is poorly understood.Aim: To review the evidence on different pathophysiological correlations of rosacea.Methods: A literature search was conducted for studies published between 1990 to March 2014. The inclusion criteria was pathophysiology, randomized controlled trials, controlled trials on rosacea.Results: Out of 5141 articles, 14 high quality studies met all the selection criteria. Of 14 articles, 5 are randomized control trials (RCTs), 2 are controlled trial, 3 comparative trials, 2 observational trials, 1 prospective and 1 diagnostic trial. The studies were categorized into two groups: the trigger factors and sub-types & symptoms. Of 7 high quality studies, 4 provided strong evidence that immune responses causing disease triggered by external/internal factors such as sunlight, food and chemical agents, 3 trials provided significant evidence of microorganisms as causative agents. The remaining trials did not provide significant evidences on pathophysiology.Conclusion: Vasculature, chronic inflammatory responses, environmental triggers, food and chemicals ingested and microorganisms either alone or in combination are responsible for rosacea. Many promising drugs are under various phases of clinical trials and interestingly, probiotics could also possibly be used as one of the treatment option.

show abstract

“…[ 6 ] The pathogenesis of rosacea is poorly understood and controversial. [ 7 ] Characteristic facial or ocular inflammation in rosacea involves both the vascular and stromal tissue of skin. A wide spectrum of clinical findings of rosacea is often observed.…”

Section: Introductionmentioning

confidence: 99%

Severe rosacea: A case report

Shirzadeh

Bagheri

Abdizadeh

et al. 2017

J Ophthalmic Vis Res

View full text Add to dashboard Cite

Purpose:To describe a case of severe rosacea with ocular involvement.Case Report:A 28-year-old female patient presented with extensive facial and ocular eruptions. She had a history of treatment with oral prednisolone due to the clinical diagnosis of lupus erythematosus (LE), which had resulted in transient improvement of the lesions, but was followed by exacerbation of the lesions. With the clinical diagnosis of severe oculofacial rosacea, she was successfully treated with oral doxycycline, steroid eye drops, and ocular lubricants. Histopathological features of skin biopsy were consistent with rosacea in the context of infection with Demodexfolliculorum. After four years, a relapse of the oculofacial lesions occurred, for which retreatment with oral tetracycline, steroid eye drops, and ocular lubricants was administered.Conclusion:Rosacea can be extremely severe and disfiguring, and it can be misdiagnosed as the pathognomonic butterfly rash of LE. Demodex carriage in rosacea is consistent and may play a significant role in the severe forms.

show abstract

Clinical evaluation of Libyan patients with rosacea and its correlation with seropositivity to Helicobacter pylori

Cited by 4 publications

References 12 publications

Assessment of Frequency of Rosacea Subtypes in Patients With Rosacea

Assessment of Frequency of Rosacea Subtypes in Patients With Rosacea

Major Pathophysiological Correlations of Rosacea: A Complete Clinical Appraisal

Severe rosacea: A case report

Contact Info

Product

Resources

About