Clinical Evaluation of Majoon Yahya Bin Khalid and Local Application of Roghan Darchini in Management of Primary Knee Osteoarthritis

Abstract

Primary knee osteoarthritis is an extremely common cause of disability of lower extremities which results due to breakdown and destruction of joint tissues. The present study was designed to evaluate the efficacy of Majoon Yahya bin Khalid and local application of Roghan Darchini in management of Primary Knee Osteoarthritis. It was an open label evaluation study for the duration of 30 days carried out on 30 patients aged between 35 to 60 years at NIUM hospital, Bengaluru, from April 2014 to Feb 2015. After taking written voluntary informed consent, test drugs Majoon Yahya bin Khalid was given 9 gm orally twice a day, and Roghan Darchini 2-3 ml for local application on the affected knee joints once a day. Subjective as well as objective parameters were evaluated at baseline, 15th and 30th day. The results were analyzed using paired proportion and paired student t tests. Significant improvement was observed in subjective parameters of joint pain and restriction of movements with p <0.001. All the five subscales of objective parameter (Knee Osteoarthritis Outcome Score) were found to be highly significant with p <0.001. The study revealed that the test drugs are effective and safe in management of primary knee osteoarthritis.

Evaluation of the Effect of Hijama Bi'l Shart in Waja-Ul-Mafasil (Knee Osteoarthritis): An Open Labelled Randomized Controlled Comparative Clinical Study

“…In Unani system of medicine, Waja-ul-Mafasil is thought to be caused due to abnormal digestion (Sū-e-Hazm) 5,25 Mixed diet may lead to slow the process of digestion resulting in production of Ghayr Tabayī Akhlāt, that's why eminent Unani physicians have advised the restriction of non-vegetarian diets in Waja-ul-Mafasil. This study result was consistent with Srinivas P et al 23 and Khalid M et al 26 Out of 40 patients, 2 (5%) patients were underweight, 28 (70%) patients were of normal BMI & 10 (25%) patients were found to be overweight. But epidemiological data supports that overall obese persons are more affected in knee OA 27,28,29 .…”