Clinical Evaluation of Orally Administered Fluorine 18 for Bone Scanning

Jones, Alfred E.; Ghaed, Nasser; Dunson, George L.; Hosain, Fazle

doi:10.1148/107.1.129

Cited by 6 publications

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“…To our knowledge, this is the first study extensively comparing the 18 F-NaF PET/CT done after IV and oral administration routes. Previous articles on this topic either were published before the PET era, the 18 F-NaF images were performed using linear detectors, [9][10][11] or were case reports describing the feasibility of the oral route in very few patients. 12,13 In this research, we compared the 2 routes by analyzing the relationship between the SUV max in bone lesions and the SUV mean of the entire skeleton and also analyzing observers agreements.…”

Section: Discussionmentioning

confidence: 99%

“…Another potential advantage of the 18 F-NaF over the 99m Tc-labeled phosphonates is the possibility of the former to be administered by oral route. Although the IV has been the main route of 18 F-NaF administration, the possibility of oral administration was already mentioned in the seminal articles on the use of the 18 F-NaF in the clinical practice 9–11 and confirmed by recent reports 12,13 …”

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confidence: 91%

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Comparison of Oral and IV 18F-NaF PET/CT Administration in the Assessment of Bone Metastases in Patients With Breast or Prostate Cancers

et al. 2023

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The aim of this study was to compare oral and IV administrations of 18 F-NaF PET/CT for detection of suspicious bone metastatic lesions of breast and prostate cancers. Patients and Methods: Thirty-six patients with breast (n = 23) or prostate (n = 13) cancers and high risk for bone metastases were prospectively evaluated. All patients underwent 2 PET/CT studies after IV and oral 18 F-NaF administration within a 2 to 23 days interval between them. The maximum SUVs from the same suspicious lesions (≤5 index lesions per patient) in both studies were measured. The target-to-background ratio (TBR), defined as the relation between the lesion maximum SUV and the whole skeletal mean SUV, was calculated for each lesion. The TBRs in the same lesion calculated using the 2 administration routes were compared. The agreements between 2 physicians in the definition of the number of lesions in both studies were also assessed using weighted κ. Results: One hundred thirty-four pairs of lesions were analyzed. There was no significant statistical difference between the median TBRs ( P = 0.212) for IV (10.33) and oral (10.85). Excellent intraobserver agreement was observed between IVand oral routes: weighted κ of 1.0 (95% confidence interval, 0.92-1.0) and 0.92 (95% confidence interval, 0.81-0.99) for physicians 1 and 2, respectively. The interobserver coefficients were 0.82 and 0.87 for "oral versus oral" and "IV versus IV," respectively. Conclusions: 18 F-NaF PET/CT studies using oral and IV routes present comparable performance; thus, it is possible to use oral route in patients with difficult venous access.

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Section: Discussionmentioning

confidence: 99%

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confidence: 91%

Comparison of Oral and IV 18F-NaF PET/CT Administration in the Assessment of Bone Metastases in Patients With Breast or Prostate Cancers

et al. 2023

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“…Como já exposto aqui, estudos anteriores mencionam a administração factível também por via oral para aquisição da imagem em equipamentos convencionais (Dworkin et al, 1966;Blau et al, 1972;Jones et al, 1973). Alguns relatos de caso publicados mais recentemente também sugerem a possibilidade dessa administração com a realização do estudo em PET/CT (Zacchi et al, 2013(Zacchi et al, , 2016.…”

Section: Estudos Comparativos Entre Cintilografia óSsea Comunclassified

“…Embora não realizada análise da biodistribuição e da dosimetria interna devido ao protocolo adotado, estudos anteriores com administração oral de fluoreto-18 em modelos caninos mostraram que o pico plasmático do 18 F-NaF oral ocorre na primeira hora após sua administração e o percentual da dose acumulada por grama de tecido ósseo é de 3 a 10 vezes maior que nos tecidos moles (Rao et al, 1995), resultando em baixa irradiação destes últimos, além de outros dados em literatura fornecendo informações relacionadas à dosimetria interna após a ingestão do 18 F-Fluoreto (Jones et al, 1973).…”

Section: Limitações Do Estudo E Considerações Finaisunclassified

Comparação entre as vias de administração intravenosa e oral do 18F-Fluoreto para a realização de PET/CT ósseo na avaliação de pacientes com neoplasia de mama ou de próstata

Rocha¹

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Bone scanning: A review of purpose and method

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Bone scanning has changed the management of patients and has increased the understanding of a number of diseases affecting the skeleton. Early diagnosis of benign and malignant bone disease has become possible many months before a standard Xray or enzyme measurement confirms the pathologic process. An intelligent approach to the technique, the instrumentation, and the radiopharmaceuticals is, however, essential. Whole-body bone scanning is a non-invasive, safe, and easy procedure. Correctly interpreted it has a major role to play in medical diagnosis.Key words: Bone scanning -Whole body scanners -Gamma cameras -99mTc-ethylhydroxydiphosphonate (EHDP).Early detection of skeletal disease has revolutionized the clinical approach to several conditions affecting the bone. This became possible following the appearance of good bone-retaining radiopharmaceuticals labeled with almost ideal tracers. These give images of the skeleton of excellent resolution and reproducibility. The sensitivity of this method is far superior to the classical diagnostic procedures of standard radiology and serum enzyme measurements [14,16,28, 55,67, 93, 105, 109, 116, 118,184,189,243,285,291] and has allowed the study of bone disease whenever objective evidence of it is doubtful or even missing.The basis for such progress, however, demands that bone scanning is performed with a perfect knowledge of the technique, i.e., with the choice of the Present address

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Clinical Evaluation of Orally Administered Fluorine 18 for Bone Scanning

Cited by 6 publications

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Comparison of Oral and IV 18F-NaF PET/CT Administration in the Assessment of Bone Metastases in Patients With Breast or Prostate Cancers

Comparison of Oral and IV 18F-NaF PET/CT Administration in the Assessment of Bone Metastases in Patients With Breast or Prostate Cancers

Comparação entre as vias de administração intravenosa e oral do 18F-Fluoreto para a realização de PET/CT ósseo na avaliação de pacientes com neoplasia de mama ou de próstata

Bone scanning: A review of purpose and method

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