Clinical Evaluation of Potential Anti-Inflammatory Effect of Vitamin D3 Adjuvant Therapy for Chronic Asthma in Iraqi Patients

Abbas, Rasha Saadi; Abdulridha, Manal Khalid; Shafek, Mostafa Abdalfatah

doi:10.22159/ijpps.2017v9i1.15487

Cited by 12 publications

(35 citation statements)

References 40 publications

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“…A recent study observed many promising preventive strategies emerged from the available results since vitamin D relatively improve pulmonary function in asthmatic patients concomitantly with reduction of inflammatory burden in those patients, suggesting that vitamin D plays effective role to be a good candidate as an adjuvant therapy, but further evaluation is needed to explore the potential effect of vitamin D supplementation in acute or chronic asthma [61].…”

Section: Asthma and Chronic Kidney Diseasesmentioning

confidence: 99%

Vitamin D Impact on Human Health and Its Relation With Several Diseases

et al. 2018

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Vitamins are organic nutrients and substances that are needed for many biochemical functions. They are one of the six essential elements required for human life. Vitamin D is also known among the public as the Sunshine vitamin, as it is produced internally within the human body when exposed to sunlight and it is well known that the big majority of United Arab Emirates (UAE) population suffer from its deficiency.They are usually not found inside the body and therefore must be eaten from food or taken by supplements. Vitamin D that is obtained from diet or body synthesis when it is exposed to sufficient sunlight is biologically inactive without the enzymatic activation that converts it into its active form in the liver and kidney.Deficiency of vitamin D could lead to many troubling diseases such as depression including seasonal affective disorder, Parkinson’s disease, Alzheimer’s disease, Arthritis (gout, osteoarthritis, tendonitis), Osteoporosis, gum and teeth diseases, obesity, diabetes, heart diseases, metabolic syndromes, immunity related diseases (sclerosis, erythematosis), and cancer, which will be discussed in this review. The main objective of the current review is to evaluate the associations of vitamin D with the diverse health outcomes according to the latest studies done so far.

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Section: Asthma and Chronic Kidney Diseasesmentioning

confidence: 99%

Vitamin D Impact on Human Health and Its Relation With Several Diseases

et al. 2018

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“…Recent study found that vitamin D reduce inflammatory burden in asthmatic patient [31], while other studies have demonstrated alterations in different endogenous antioxidants in patients with asthma which may involve either an increase or a decrease pattern depending on the changes occurring due to a defense response [32]. In this study, the effect of vitamin D 3 supplementation on EC-SOD, SOD3 showed a significant increase in SOD3 antioxidant enzyme after 3 months treatment with vitamin D 3 supplementation to conventional therapy in Group 2 patients (p<0.05), meanwhile significant decrease of this enzyme activity after 3 months treatment with conventional therapy alone in Group 1 patients (p<0.05).…”

Section: Discussionmentioning

confidence: 99%

Study the Potential Antioxidant Effect of Vitamin D3 Supplementation on the Level of Extracellular Superoxide Dismutase in Asthmatic Patients

Abbas

Abdulridha

Shafek

2017

Asian J Pharm Clin Res

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Objective: This study was designed to evaluate the potential antioxidant effect of vitamin D 3 supplementation in chronic asthma patients.Methods: A total of 44 candidate patients were diagnosed with asthma allocated as Group 1 includes 20 patients assigned to receive conventional therapy for asthma and Group 2 includes 24 patients assigned to receive conventional therapy for asthma plus 2000 IU vitamin D 3 tablet for 3-month period. Furthermore, 30 apparently healthy subjects were included in the study as a control group. Pulmonary function test, serum 25-hydroxy vitamin D levels, serum extracellular superoxide dismutase (SOD3) levels were measured before and after 3 months therapy. Results:The mean forced expiratory volume in 1 second (FEV1) both the measured and the percentage of predicted value showed a highly significant increase after 3 months treatment compared to pre-treatment value in both study groups (p<0.01). When compared to pre-treatment value, there was no significant increase in forced expiratory volume in one second to forced vital capacity ratio (FEV1/FVC) in Group 1 (p>0.05), nevertheless, Group 2 showed highly significant increase after 3 months (p<0.01). Approximately, 90-96% of adult asthmatic patients revealed vitamin D deficiency (<20 ng/ml). Post-treatment with adjuvant vitamin D 3 therapy, 25% of patients obtained acceptable level of vitamin D sufficiency (≥30 ng/ml). After 3 months of the treatment, Group 1 patients showed a significant decrease in mean SOD3 level compared to pre-treatment level (p<0.05), while Group 2 patients showed a significant increase in mean SOD3 level compared to pre-treatment level (p<0.05). Conclusion:Most of the asthmatic patients revealed vitamin D deficiency and supplementation with vitamin D3 reduce oxidative stress burden in those patients.

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“…Anti-inflammatory effect of Vitamin D3 supplementation has been proved in patients with asthma [81].…”

Section: Treatment Approachesmentioning

confidence: 99%

Allergic Manifestations of Primary Immunodeficiency Diseases and Its Treatment Approaches

Boyarchuk

2018

Asian J Pharm Clin Res

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Allergic manifestations are one of the clinical signs of primary immunodeficiency diseases (PID). In this review, the common allergic manifestations of PID are summarized, and their main differential characteristics and treatment approaches are outlined. Allergic manifestations occur more often in patients with combined immunodeficiencies with or without associated or syndromic features. In patients with PID they usually are present in the 1st year of life, may be among the first symptoms of PID, and are commonly manifested by eczema and increased immunoglobulin (Ig)-G levels. Often the skin barrier function is not impaired in patients with eczema and PID, although some diseases (such as Comel-Netherton syndrome) do affect skin barrier function. There is usually no correlation between IgE levels and the severity of allergic skin manifestations. Allergic-like manifestations in PID patients include urticaria-like rash and angioedema. Urticaria-like rash is associated with autoinflammatory disorders, which are commonly accompanied by fever, and caused by a neutrophilic infiltrate in the dermis. Angioedema in hereditary angioedema patients is caused by high bradykinin production. Early differentiation of allergic manifestations in PID from atopic dermatitis and other atopic conditions is very difficult; however, it is very important because it influences on treatment methods. A multidisciplinary approach to the management of PID patients, with the involvement of immunologists, allergists, and formulation of appropriate treatment improve the prognosis and quality of life of the PID patients.

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Clinical Evaluation of Potential Anti-Inflammatory Effect of Vitamin D3 Adjuvant Therapy for Chronic Asthma in Iraqi Patients

Cited by 12 publications

References 40 publications

Vitamin D Impact on Human Health and Its Relation With Several Diseases

Vitamin D Impact on Human Health and Its Relation With Several Diseases

Study the Potential Antioxidant Effect of Vitamin D3 Supplementation on the Level of Extracellular Superoxide Dismutase in Asthmatic Patients

Allergic Manifestations of Primary Immunodeficiency Diseases and Its Treatment Approaches

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