Clinical evaluation of pregnant women with SARS-COV2 pneumonia: a real-life study from Egypt

Abstract

Background Knowledge about the outcome of COVID-19 on pregnant women is so important. The published literature on the outcomes of pregnant women with COVID-19 is confusing. The aim of this study was to report our clinical experience about the effect of COVID-19 on pregnant women and to determine whether it was associated with increased mortality or an increase in the need for mechanical ventilation in this special category of patients. Methods This was a cohort study from some isolation hospitals of the Ministry of Health and Population, in eleven governorates, Egypt. The clinical data from the first 64 pregnant women with COVID-19 whose care was managed at some of the Egyptian hospitals from 14 March to 14 June 2020 as well as 114 non-pregnant women with COVID-19 was reviewed. Results The two groups did not show any significant difference regarding the main outcomes of the disease. Two cases in each group needed mechanical ventilation (p 0.617). Three cases (4.7%) died among the pregnant women and two (1.8%) died among the non-pregnant women (p 0.352). Conclusions The main clinical outcomes of COVID-19 were not different between pregnant and non-pregnant women with COVID-19. Based on our findings, pregnancy did not exacerbate the course or mortality of COVID-19 pneumonia.

Study of foetomaternal outcomes in COVID-19 afflicted parturients who underwent operative delivery - A retrospective analysis

“…Zaky et al . [ 12 ] compared the outcome of COVID-19 infection on 64 Egyptian pregnant women with 114 non-pregnant women. They also reported that the two groups did not differ either in maternal complications (need for mechanical ventilation or mortality), or foetal complications (preterm labour, hydrocephalus or intrauterine foetal death).…”

SARS‑CoV‑2 infection and children: Insights from the 6th Workshop on Paediatric Virology (Review)

“…Looking back, 14 months after the '6th Workshop on Paediatric Virology', the volume of literature and data on SARS-CoV-2 and COVID-19 being published daily by the world scientific community is impressive (83)(84)(85)(86)(87)(88)(89)(90)(91)(92)(93). Since the workshop, as expected for a RNA virus, multiple variants of SARS-CoV-2 have emerged.…”

“…To date, SARS-CoV-2 VOCs, which have been named using letters of the Greek alphabet and initially identified in various countries include Alpha (B. (89). Additional research has confirmed that vertical transmission is rare, with perinatal transmission occurring in some instances (90).…”

“…The absence of the co-expression of TMPRSS2 and ACE-2 in the placenta across the second trimester and at term, as well as the absence of ACE2 in the foetal lung help explain the rarity of vertical transmission (93). Fortunately, COVID-19 symptoms in children tend to be milder and slightly different from those in adults (89). Both vaccination schedules and treatment algorithms need to be further tested and optimized for children and infants.…”

Exploring Clinical and Biological Features of Premature Births among Pregnant Women with SARS-CoV-2 Infection during the Pregnancy Period

“…Pregnancy status does not seem to increase the likelihood of COVID-19, and the majority of pregnant patients with SARS-CoV-2 infection tend to recover before the moment of giving birth [1,2]. In pregnant women infected with SARS-CoV-2, the rates of mild, moderate, and severe disease are comparable to those in the general population [3][4][5], although some data suggests that pregnant women diagnosed with COVID-19 had a higher rate of more severe complications than the general population, due to pregnancyspecific comorbidities overlapping the acute SARS-CoV-2 infection [6][7][8]. It is hypothesized that viral infections during the pregnancy period may affect the moment of delivery, determining a premature birth, fetal health, and development, as well as increasing the risk for infertility [9][10][11][12]; therefore, a probable consequence of COVID-19 infection during pregnancy, a syndrome resembling preeclampsia has been reported during the second and third trimesters, increasing the fetal health risk as well as the likelihood of giving birth prematurely [13,14].…”