Clinical Evaluation of Red Blood Cell Tocopherol*

Mino, Makoto; Nakagawa, Shigeto; and, H. Tamai. And; Miki, Masayuki

doi:10.1111/j.1749-6632.1982.tb31245.x

Cited by 31 publications

(5 citation statements)

References 7 publications

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“…We found erythrocyte a-tocopherol levels in the neonatal period comparable to those of adults (Mino et al, 1982(Mino et al, , 1985Mino, 1992;Kaempf et al, 1994), but, as found by Kaempf, they rose during the ®rst months of life (Kaempf et al, 1994). We used infant formulas with a higher amount of vitamin E than in those used in other studies and, although the infants fed on formula had a higher erythrocyte vitamin E concentration at 1 month than infants fed on human milk at 3 months, the differences were not signi®-cant.…”

Section: Discussionsupporting

confidence: 72%

“…In other studies, full-term infants fed infant formulas without LCPUFAs and a similar amount of vitamin E (6± 6.5 mg/l) for 1 week did not achieve a similar plasma or erythrocyte a-tocopherol increase to that of infants fed on human milk, and the difference was greater in erythrocytes than in plasma (Mino et al, 1982;Paredes et al, 1990). Infants fed formulas containing higher amounts of vitamin E without LCPUFAs (9.1±11.6 mg/l) showed a progressive increase in their plasma vitamin E similar to those achieved in human milk-fed infants after 1 week (Ostrea et al, 1986).…”

Section: Discussionmentioning

confidence: 89%

“…The majority of studies on the in¯uence of the diet of atocopherol levels in infants analyse only plasma a-tocopherol levels (Phelps & Dietz, 1981;Martõ Ânez et al, 1984;Gross & Gabriel, 1985;Ostrea et al, 1986;Hayes et al, 1992;Uauy et al, 1994;Decsi & Koletzko, 1995;Koletzko et al, 1995a), although some studies show a closer relation between erythrocyte and platelet a-tocopherol with a-tocopherol dietetic changes than for plasma values both in adults and in neonates studies (Mino, 1982;Haddad et al, 1985;Lehmann et al, 1988;Saito et al, 1992;Koletzko et al, 1995b;Rodriguez-Palmero et al, 1997a).…”

mentioning

confidence: 99%

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Plasma and erythrocyte α-tocopherol and plasma retinol concentrations in term infants fed formula enriched with long-chain polyunsaturated fatty acids

et al. 1998

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Objective: To assess the effect of long-chain polyunsaturated fatty acids (LCPUFA)-and vitamin Esupplemented formula feeding on erythrocyte and plasma a-tocopherol (VE), and plasma retinol (VA) concentrations in neonates and to compare these values with those found in infants feeding on infant formula without LCPUFA or breast milk Setting: University Hospital of Granada, Spain. Subjects: 49 full-term infants. Design and intervention: Subjects who chose not to breast feed were fed either (i) unsupplemented infant formula (F) or (ii) infant formula supplemented with LCPUFA and vitamin E (FL). a-Tocopherol and retinol were measured at 7 days, 1 month and 3 months. Results: Plasma and erythrocyte VE concentrations and plasma VE/total lipids ratio increased signi®cantly in all groups at 1 month of life (P`0.05), but did not change signi®cantly between 1 month and 3 months in any group (P b 0.05). Erythrocyte VE and VA retinol concentrations were higher in infants fed an infant formula than in breast milk-fed infants at 1 month of life (P`0.05). Finally, there were no signi®cant differences in plasma or erythrocyte VE levels, plasma VA or plasma VE/total lipid ratio between any groups at 3 months of life (P b 0.05). Conclusion: Infants fed on LCPUFA-and vitamin E-supplemented infant formula for 3 months have similar vitamin E and A status to infants fed on breast milk or infant formula without LCPUFA supplementation.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 89%

mentioning

confidence: 99%

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Plasma and erythrocyte α-tocopherol and plasma retinol concentrations in term infants fed formula enriched with long-chain polyunsaturated fatty acids

et al. 1998

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“…Although plasma le vels are normal, because of the importance of the mem brane action of vitamin E, the level in the red cell needs to be directly measured rather than continuing to rely on plasma levels of vitamin E [23]. This is particularly im portant as hemolysis may be more directly related to the tocopherol in RBCs than plasma [24], It is known that a-tocopherol is the predominant form of vitamin E in both plasma and RBCs and all a-tocopherol in the RBCs is localized in the membrane fraction [6], a-Tocopherol concentration ranges from 6.6 to 15 (mean 9.6 ug/ml) in plasma and from 0.9 to 1.8 pg/ml packed cells (mean 1.4 ug/ml) in normal subjects [6]. One author has suggested that tocopherol in plasma equilibrates rather rapidly with RBCs [19] and another has suggested that the ratio of tocopherol in RBCs to plasma differs between animals species, but it is relatively constant within the same spe cies [13].…”

Section: Discussionmentioning

confidence: 99%

Effects of Large Dose Vitamin E Supplementation on Anemia in Hemodialysis Patients

Ono

1985

Nephron

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In order to clarify the effect of vitamin E (α-tocopherol) on anemia and the osmotic fragility of red blood cells (RBC) plasma and RBC levels of vitamin E were measured in 30 regular dialysis patients before and after oral supplementation of vitamin E, 600 mg daily for 30 days. Plasma levels of vitamin E were in the normal range (10.67 ± 0.85, 9.73 ± 0.77 μg/ml) but RBC levels in packed red cells were significantly lower than healthy controls (0.57 ± 0.05, 0.45 ± 0.07 μg/ml). Oral supplementation of vitamin E increased both plasma (20.37 ± 1.61 μg/ml) and RBC vitamin E (1.56 ± 0.11 μg/ml) in packed red cells, while in unsupplemented patients, vitamin E levels remained unchanged. In patients receiving vitamin E, mean osmolarities at the beginning and end of hemolysis decreased from 102.8 ± 0.9 to 98.9 ± 0.7 and 72.1 ± 1.1 to 67.4 ± 0.8 mosm/1, respectively. In addition, the hematocrit increased from 26.1 ± 1.0 to 28.1 ± 1.2%. These changes are statistically significant (p < 0.05). In conclusion, the oral supplementation of vitamin E could be of clinical benefit in correcting anemia in regular dialysis patients by reducing the fragility of RBCs.

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“…An additional limitation of this study is the measurement of serum rather than red blood cell associated α-tocopherol levels, which may correlate better with in vivo antioxidant protection. 32 However, previous investigators have shown a very strong correlation between levels measured at these two sites. 33 Although our results may suggest that higher doses of vitamin E are required, caution is necessary in light of previous experience, where prolonged elevations in serum vitamin E levels were associated with an increased incidence of sepsis and necrotising enterocolitis in very low birth weight infants.…”

Section: F326mentioning

confidence: 87%

Effects of vitamin E supplementation during erythropoietin treatment of the anaemia of prematurity

Pathak

Roth²,

Piscitelli³

et al. 2003

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Aims: To evaluate the effects of vitamin E supplementation on haemoglobin concentration and the requirement for transfusion in premature infants treated with erythropoietin and iron. Methods: Randomised, double blind, placebo controlled trial. Thirty infants <32 weeks gestation and <1250 g birth weight, who were defined as stable based on minimal requirements for respiratory support and phlebotomy, and absence of major congenital anomalies were enrolled. All were treated with erythropoietin and iron, and were randomised to receive, in addition, either vitamin E 50 IU/day or placebo for eight weeks or until discharge, whichever came first. Results: Despite higher vitamin E (α-tocopherol) levels in the experimental group in weeks 3 (49.0 v 28.1 µmol/l) and 8 (66.2 v 38.5 µmol/l), there were no differences in haemoglobin, reticulocyte count, iron concentration, or transfusion requirement. Conclusions: Oral vitamin E supplementation at 50 IU/day does not increase the response of preterm infants to erythropoietin and iron. Vitamin E obtained through standard nutrition may have been sufficient or higher doses may be required.

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Clinical Evaluation of Red Blood Cell Tocopherol*

Cited by 31 publications

References 7 publications

Plasma and erythrocyte α-tocopherol and plasma retinol concentrations in term infants fed formula enriched with long-chain polyunsaturated fatty acids

Plasma and erythrocyte α-tocopherol and plasma retinol concentrations in term infants fed formula enriched with long-chain polyunsaturated fatty acids

Effects of Large Dose Vitamin E Supplementation on Anemia in Hemodialysis Patients

Effects of vitamin E supplementation during erythropoietin treatment of the anaemia of prematurity

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