Clinical evaluation of red cell distribution width and contrast-induced acute kidney injury in percutaneous coronary interventions

Nichols, Elizabeth L.; Brown, Jeremiah R.

doi:10.1097/mca.0000000000000239

Cited by 5 publications

(2 citation statements)

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“…Recently, the use of the RDW as a simple and inexpensive biomarker to predict mortality in chronic heart failure [ 18 , 28 ], liver disease [ 29 ], and critical illness [ 30 ] has increased. Moreover, the RDW has been reported to be associated with many pathological conditions such as colon cancer, inflammatory bowel disease, celiac disease, rheumatoid arthritis, Alzheimer’s disease, and contrast-induced nephropathy [ 31 , 32 ]. Although the exact mechanism of this relationship is not clear, inflammation is a proposed underlying factor [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Acute Kidney Injury and In-Hospital Mortality in Patients Receiving Extracorporeal Membrane Oxygenation

Lee

et al. 2015

PLoS ONE

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Background and ObjectivesAlthough acute kidney injury (AKI) is the most frequent complication in patients receiving extracorporeal membrane oxygenation (ECMO), few studies have been conducted on the risk factors of AKI. We performed this study to identify the risk factors of AKI associated with in-hospital mortality.MethodsData from 322 adult patients receiving ECMO were analyzed. AKI and its stages were defined according to Kidney Disease Improving Global Outcomes (KDIGO) classifications. Variables within 24 h before ECMO insertion were collected and analyzed for the associations with AKI and in-hospital mortality.ResultsStage 3 AKI was associated with in-hospital mortality, with a hazard ratio (HR) (95% CI) of 2.690 (1.472–4.915) compared to non-AKI (p = 0.001). The simplified acute physiology score 2 (SAPS2) and serum sodium level were also associated with in-hospital mortality, with HRs of 1.02 (1.004–1.035) per 1 score increase (p = 0.01) and 1.042 (1.014–1.070) per 1 mmol/L increase (p = 0.003). The initial pump speed of ECMO was significantly related to in-hospital mortality with a HR of 1.333 (1.020–1.742) per 1,000 rpm increase (p = 0.04). The pump speed was also associated with AKI (p = 0.02) and stage 3 AKI (p = 0.03) with ORs (95% CI) of 2.018 (1.129–3.609) and 1.576 (1.058–2.348), respectively. We also found that the red cell distribution width (RDW) above 14.1% was significantly related to stage 3 AKI.ConclusionThe initial pump speed of ECMO was a significant risk factor of in-hospital mortality and AKI in patients receiving ECMO. The RDW was a risk factor of stage 3 AKI.

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Section: Discussionmentioning

confidence: 99%

Risk Factors for Acute Kidney Injury and In-Hospital Mortality in Patients Receiving Extracorporeal Membrane Oxygenation

Lee

et al. 2015

PLoS ONE

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“…High RDW is related to impairment of erythropoiesis, reflecting chronic inflammation and increased levels of oxidative stress, both of which are telltale signs of coronary artery disease [15]. Very recently, several studies showed that RDW has become a target of investigations into new predictors of mortality and kidney function after PCI [16]. Kurtul A et al showed that increased RDW on admission is independently associated with a greater risk of CIN in patients undergoing PCI for acute coronary syndrome [17].…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 98%

Role of red blood cell distribution width in predicting contrast induced nephropathy in patients with stable angina pectoris undergoing percutaneous coronary intervention

Zhao

Gao

2015

International Journal of Cardiology

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Prognostic value of red cell distribution width in patients undergoing percutaneous coronary intervention: a meta-analysis

Bao¹,

Luo²,

Kan³

et al. 2020

BMJ Open

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ObjectiveTo evaluate the prognostic value of baseline red cell distribution width (RDW) in patients with coronary artery diseases (CADs) undergoing percutaneous coronary intervention (PCI) by conducting a meta-analysis.DesignSystematic review and meta-analysis.Data sourcePubMed, Embase, Wanfang, CNKI and VIP databases were searched from their inceptions to 19 June 2019.Eligible criteriaStudies investigating the value of baseline RDW for predicting all-cause mortality, cardiovascular mortality and major adverse cardiac events (MACEs) in patients with CAD undergoing PCI were included.Data extraction and synthesisTwo authors independently extracted the data and evaluated the methodological quality using the Newcastle–Ottawa Scale. STATA V.12.0 software was applied to produce the forest plots using a random-effect model.ResultsTwelve studies (13 articles) involving 17 113 patients were included and analysed. Comparison between the highest and lowest RDW category indicated that the pooled risk ratio (RR) was 1.77 (95% CI 1.32 to 2.37) for all-cause mortality, 1.70 (95% CI 1.25 to 2.32) for cardiovascular mortality and 1.62 (95% CI 1.21 to 2.18) for MACEs. The predictive effect of elevated RDW for all-cause mortality was stronger in the subgroup of patients without anaemia (RR 4.59; 95% CI 3.07 to 6.86) than with anaemia.ConclusionsThis meta-analysis indicated that elevated RDW was associated with higher risk of mortality and adverse cardiac events in patients with CAD undergoing PCI. The value of elevated RDW for predicting all-cause mortality appears to be stronger in patients without anaemia. RDW may be served as a promising prognostic biomarker in patients undergoing PCI.

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Clinical evaluation of red cell distribution width and contrast-induced acute kidney injury in percutaneous coronary interventions

Cited by 5 publications

References 20 publications

Risk Factors for Acute Kidney Injury and In-Hospital Mortality in Patients Receiving Extracorporeal Membrane Oxygenation

Risk Factors for Acute Kidney Injury and In-Hospital Mortality in Patients Receiving Extracorporeal Membrane Oxygenation

Role of red blood cell distribution width in predicting contrast induced nephropathy in patients with stable angina pectoris undergoing percutaneous coronary intervention

Prognostic value of red cell distribution width in patients undergoing percutaneous coronary intervention: a meta-analysis

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