Clinical Evaluation of the Use of the M2A Patency Capsule System Before a Capsule Endoscopy Procedure, in Patients with Known or Suspected Intestinal Stenosis

Delvaux, Michel; Soussan, Emmanuel Ben; Laurent, V.; Lerebours, Éric

doi:10.1055/s-2005-870241

Cited by 142 publications

(59 citation statements)

References 13 publications

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“…In all of these the video capsule passed through the small-bowel stricture without complication. The rate of patients with the PC excreted intact was similar in the seria of Boivin et al [25] (16/22, 73%), Delvaux et al [26] (16/22, 73%), Signorelli et al [27] (26/32, 81%). In our center, the percentage of cases with PC excreted intact was significant lower (13/29, 45%), probably because of patient selection [28] .…”

Section: Clinical Trials With Patency Capsulementioning

confidence: 60%

“…A prospective, multi-center trial was designed to assess the clinical usefulness and safety of the PC capsule in patients with intestinal strictures suspected from clinical and/or radiological data. The global data of this trial have not been published, but the results of four of these centers have been reported (Table 1) [24][25][26][27] . In the series reported by Spada et al [24] , 30 out of 34 (88.2%) patients with known or suspected small bowel stricture retrieved the capsule in the stool.…”

Section: Clinical Trials With Patency Capsulementioning

confidence: 99%

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Patency© and agile© capsules

Caunedo-Álvarez

Romero-Vázquez²,

Herrerías‐Gutiérrez³

2008

WJG

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Small bowel strictures can be missed by current diagnostic methods. The Patency capsule is a new non-endoscopic dissolvable capsule which has as an objective of checking the patency of digestive tract, in a non-invasive manner. The available clinical trials have demonstrated that the Patency © capsule is a good tool for assessment of the functional patency of the small bowel, and it allows identification of those patients who can safely undergo a capsule endoscopy, despite clinical and radiographic evidence of small-bowel obstruction. Some cases of intestinal occlusion have been reported with the Patency © capsule, four of them needed surgery. So, a new capsule with two timer plugs (Agile © capsule) has been recently developed in order to minimize the risk of occlusion. This new device stars its dissolution process earlier (30 h after ingestion) and its two timer plugs have been designed to begin the disintegration even when the device is blocked in a tight stricture.

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Section: Clinical Trials With Patency Capsulementioning

confidence: 60%

Section: Clinical Trials With Patency Capsulementioning

confidence: 99%

Patency© and agile© capsules

Caunedo-Álvarez

Romero-Vázquez²,

Herrerías‐Gutiérrez³

2008

WJG

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“…However, in the study of Bovin et al [14] , in one of the 22 cases with suspected obstructive intestinal disease and/or radiological evidence of smallbowel strictures, impaction of an intact capsule led to ileus and emergency surgery. Similarly, in the study of Delvaux et al [15] , of all 22 patients with known or suspected stenosis, the patency capsule induced a symptomatic intestinal occlusion in three patients, which was resolved spontaneously in one and required emergency surgery in two. It was shown that the start of dissolution at 40 h after ingestion was too late to prevent intestinal occlusion.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Effect of Capsule Endoscopy in 31 Cases with Subacute Small Bowel Obstruction

Chen¹,

Yang²

2009

Gastrointestinal Endoscopy

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“…Importantly, it is not a risk-free procedure, as there have been reported cases of temporary intestinal occlusion and in a study conducted on 22 patients evaluating the usefulness of the patency capsule in patients with suspected small bowel stenosis, 3 patients had intestinal occlusion which required emergency surgery in 2 [21].…”

Section: Discussionmentioning

confidence: 99%

Is the use of AGILE patency capsule prior to videocapsule endoscopy useful in all patients with spondyloarthritis?

Gheorghe

Zahiu

Voiosu

et al. 2017

Romanian Journal of Internal Medicine

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Background and aims. As already known, spondyloarthritis patients present a striking resemblance in intestinal inflammation with early Crohn's disease. Moreover, the frequent use of nonsteroidal anti-inflammatory drugs is an important part of their treatment. Both conditions could lead to intestinal stenoses. Therefore we proposed to investigate the usefulness of the patency capsule test in patients with spondyloarthritis.Material and methods. 64 consecutive patients (33 males; mean age 38 ± 11 years) that fulfilled the AMOR criteria for seronegative spondyloarthropathy (59.4% ankylosing spondylitis) lacking symptoms or signs of intestinal stenosis were enrolled and submitted to an AGILE™ capsule patency test followed by a video capsule endoscopy (PillCam SB2™), as part of a protocol investigating the presence of intestinal inflammatory lesions. After reviewing the VCE recordings, the Lewis score (of small bowel inflammatory involvement) was computed.Results. In only 5 patients (7.8%) of the study group, the luminal patency test was negative. However, there was no retention of the videocapsule in any of the patients. From the 59 patients with a positive patency test, 3 patients presented single small bowel stenoses (two with ulcerated overlying inflamed mucosa, one cicatricial), all being traversed by the videocapsule along the length of the recording. None of the patients with a negative test had bowel stenoses. There was no correlation between the patency test and the Lewis score, the C reactive protein value, diagnosis of inflammatory bowel disease, or the family history of spondyloarthritis, psoriasis or inflammatory bowel disease.Conclusion. The AGILE patency capsule does not seem to be a useful tool for all patients with spondyloarthritis prior to small bowel videocapsule endoscopy (ClinicalTrial.gov ID NCT 00768950).

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Clinical Evaluation of the Use of the M2A Patency Capsule System Before a Capsule Endoscopy Procedure, in Patients with Known or Suspected Intestinal Stenosis

Cited by 142 publications

References 13 publications

Patency© and agile© capsules

Patency© and agile© capsules

The Diagnostic Effect of Capsule Endoscopy in 31 Cases with Subacute Small Bowel Obstruction

Is the use of AGILE patency capsule prior to videocapsule endoscopy useful in all patients with spondyloarthritis?

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