Clinical evaluation of three‐dimensional late enhancement MRI

Bratis, Konstantinos; Henningsson, Markus; Grigoratos, Chrysanthos; Omodarme, Matteo Dell'; Chasapides, Konstantinos; Botnar, René M.; Nagel, Eike

doi:10.1002/jmri.25512

Cited by 15 publications

(29 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The in‐plane resolution of the 2D scan was higher than the 3D; in our study the 2D scan was clinically optimized and established and we wanted to directly compare with it; the 3D scan was separately optimized, balancing resolution and acceleration. Typically, 3D LGE techniques have been shown to have compromised image quality compared with 2D techniques, although differences in qualitative ratings often do not reach significance . Our findings were that categorical image scoring of the 3D mDIXON sequence was in fact very comparable to the 2D LGE sequence.…”

Section: Discussionmentioning

confidence: 57%

“…Therefore, accurate discrimination of transmural scar extent is important when considering a new LGE sequence. Previous studies have showed variable results, although more recent studies have shown reasonable agreement . The 3D mDIXON technique showed strong agreement with the 2D sequences.…”

Section: Discussionmentioning

confidence: 70%

“…3D acquisition methods have been developed in recent years that cover the entire LV in a single breath‐hold or via navigator‐based free‐breathing sequences . Studies evaluating 3D techniques have suggested the potential use of 3D LGE imaging in a variety of different patient groups . Thus far, single breath‐hold 3D LGE techniques have typically reported a compromise in image quality, mainly due to movement artifacts resulting from the very long breath‐hold durations required .…”

mentioning

confidence: 99%

See 2 more Smart Citations

Feasibility study of a single breath‐hold, 3D mDIXON pulse sequence for late gadolinium enhancement imaging of ischemic scar

Foley

Fent

Garg

et al. 2018

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background Late gadolinium enhancement (LGE) imaging is well validated for the diagnosis and quantification of myocardial infarction (MI). 2D LGE imaging involves multiple breath‐holds for acquisition of short‐axis slices to cover the left ventricle (LV). 3D LGE methods cover the LV in a single breath‐hold; however, breath‐hold duration is typically long with images susceptible to motion artifacts. Purpose/Hypothesis To assess a single breath‐hold 3D mDIXON LGE pulse sequence for image quality and quantitation of MI. Study Type Prospective. Population Ninety‐ two patients with prior MI. Field Strength/Sequence 1.5T cardiac MRI protocol using both conventional 2D phase sensitive inversion recovery and 3D mDIXON LGE imaging 10 minutes following contrast administration in random order to avoid bias. Assessment Data were analyzed qualitatively for image quality (three observers). Quantitative assessment of myocardial scar mass (full‐width half‐maximum), scar transmurality, and contrast‐to‐noise ratio measurements were performed. Time for 2D and 3D LGE imaging was recorded. Statistical Tests Paired Student's t‐test, Wilcoxon rank test, Cohen κ statistic, Pearson correlation, linear regression, and Bland–Altman analysis. Results Image quality scores were comparable between 3D and 2D LGE (1.4 ± 0.6 vs. 1.3 ± 0.5; P = 0.162). 3D LGE was associated with greater scar tissue mass (3D: 18.9 ± 17.5 g vs. 2D: 17.8 ± 16.2 g P = 0.03), although this difference was less pronounced when scar tissue was expressed as %LV mass (3D: 13.4 ± 9.9% vs. 2D: 12.7 ± 9.5% P = 0.07). For 3D vs. 2D scar mass there was a strong and significant positive correlation; Bland–Altman analysis showed mean mass bias of 1.1 g (95% confidence interval [CI]: –5.7 to 7.9). Segmental level agreement of scar transmurality between 3D and 2D LGE at the clinical viability threshold of 50% transmurality was excellent (κ = 0.870). 3D image acquisition (15.6 ± 1.4 sec) was just 5% of time required for 2D images (311.6 ± 43.2 sec) P < 0.0001. Data Conclusion Single breath‐hold 3D mDIXON LGE imaging allows quantitative assessment of MI mass and transmurality, with comparable image quality, in vastly shorter overall acquisition time compared with standard 2D LGE imaging. Level of Evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:1437–1445.

show abstract

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 70%

mentioning

confidence: 99%

See 1 more Smart Citation

Feasibility study of a single breath‐hold, 3D mDIXON pulse sequence for late gadolinium enhancement imaging of ischemic scar

Foley

Fent

Garg

et al. 2018

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…These navigated sequences may enable the assessment of thin walled structures such as atria and RV free wall although acquisition durations are long (typically 5–10 min) and unpredictable (69). …”

Section: Focal Fibrosis and Scarringmentioning

confidence: 99%

Myocardial Architecture, Mechanics, and Fibrosis in Congenital Heart Disease

Ghonim

Voges

Gatehouse

et al. 2017

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Congenital heart disease (CHD) is the most common category of birth defect, affecting 1% of the population and requiring cardiovascular surgery in the first months of life in many patients. Due to advances in congenital cardiovascular surgery and patient management, most children with CHD now survive into adulthood. However, residual and postoperative defects are common resulting in abnormal hemodynamics, which may interact further with scar formation related to surgical procedures. Cardiovascular magnetic resonance (CMR) has become an important diagnostic imaging modality in the long-term management of CHD patients. It is the gold standard technique to assess ventricular volumes and systolic function. Besides this, advanced CMR techniques allow the acquisition of more detailed information about myocardial architecture, ventricular mechanics, and fibrosis. The left ventricle (LV) and right ventricle have unique myocardial architecture that underpins their mechanics; however, this becomes disorganized under conditions of volume and pressure overload. CMR diffusion tensor imaging is able to interrogate non-invasively the principal alignments of microstructures in the left ventricular wall. Myocardial tissue tagging (displacement encoding using stimulated echoes) and feature tracking are CMR techniques that can be used to examine the deformation and strain of the myocardium in CHD, whereas 3D feature tracking can assess the twisting motion of the LV chamber. Late gadolinium enhancement imaging and more recently T1 mapping can help in detecting fibrotic myocardial changes and evolve our understanding of the pathophysiology of CHD patients. This review not only gives an overview about available or emerging CMR techniques for assessing myocardial mechanics and fibrosis but it also describes their clinical value and how they can be used to detect abnormalities in myocardial architecture and mechanics in CHD patients.

show abstract

“…While adenosine stress imaging assesses myocardial perfusion, late gadolinium enhancement (LGE) depicts myocardial scar . Recently introduced 3D acquisition sequences make use of 3D excitation and readout of the entire examination volume at once instead of repeatedly acquiring separate slices . For perfusion imaging, such 3D sequences proved diagnostic accuracy at higher spatial resolutions .…”

mentioning

confidence: 99%

3D image fusion of whole‐heart dynamic cardiac MR perfusion and late gadolinium enhancement: Intuitive delineation of myocardial hypoperfusion and scar

Spiczak

Mannil

Kozerke

et al. 2018

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

Clinical evaluation of three‐dimensional late enhancement MRI

Abstract: 2 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;45:1675-1683.

Cited by 15 publications

References 22 publications

Feasibility study of a single breath‐hold, 3D mDIXON pulse sequence for late gadolinium enhancement imaging of ischemic scar

Feasibility study of a single breath‐hold, 3D mDIXON pulse sequence for late gadolinium enhancement imaging of ischemic scar

Myocardial Architecture, Mechanics, and Fibrosis in Congenital Heart Disease

3D image fusion of whole‐heart dynamic cardiac MR perfusion and late gadolinium enhancement: Intuitive delineation of myocardial hypoperfusion and scar

Contact Info

Product

Resources

About