Clinical evaluation of total intravenous anaesthesia using xylazine or dexmedetomidine with propofol in surgical management of canine patients

Jena, Biswadeep; Das, Jayakrushna; Nath, I.; Sardar, K. K.; Sahoo, Abhishek; Beura, Sasanka Sekhar; Painuli, Abhishek

doi:10.14202/vetworld.2014.671-680

Cited by 17 publications

(18 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased CORT level is in agreement with the findings of [ 37 ], indicating that CORT concentration could be suppressed 30 min after induction of West African Dwarf goats with xylazine and propofol and a surge in CORT concentrations was observed 2 h postsurgery. Similar findings were reported postsurgery [ 33 , 38 ]. The value of CORT began to fall at 24 h postsurgery for the three groups and was significant at 24 h for Group 3 and 96 h for both Groups 1 and 3.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Effects of various surgical procedures on biochemical parameters of Nigerian dogs and their clinical implications

2018

View full text Add to dashboard Cite

Aim:The importance of physical and psychological stress caused by pain during surgery cannot be overemphasized. The aim of this study was to assess the effects of ovariohysterectomy (OVH), gastrotomy (GST), and intestinal resection and anastomosis (IRA) on biochemical parameters of Nigerian dogs anesthetized with the xylazine-propofol combination.Materials and Methods:A total of 12 dogs were randomly divided into three groups of four each. The animals were treated with xylazine and propofol anesthetics for OVH, GST, and IRA in Groups 1-3, respectively. Blood samples were collected at 0 h, 2, 24, 48, 72, 96, 120, and 144 h postsurgery for determination of cortisol (CORT), glucose (GLU), total protein (TP), albumin (ALB), globulin (GL), and ALB/GL ratio.Results:There were significant increases (p<0.05) in mean CORT concentrations 2 h postsurgery in the three groups and at 24 h in Group 3 and 96 h in Groups 1 and 3, respectively. GLU concentrations increased significantly (p<0.05) in the three groups at 2 h postsurgery. The mean protein concentrations in Groups 2 and 3 decreased significantly (p<0.05) at 2h and 24 h and 72 h, 96 h, 120 h, and 144 h in Group 3, respectively. There was significant decrease (p<0.05) in the mean ALB concentrations at 2 h, 24 h, 72 h, 96 h, 120 h, and 144 h postsurgery. There was a significant difference (p<0.05) in the mean GL concentrations in Group 3 at 24 h, 72 h, 96 h, and 144 h. All other parameters were not significantly different (p>0.05) in comparison with the control.Conclusion:Xylazine-propofol combination could decrease humoral immune status and increase serum GLU level invariably portending a high risk of diabetes in the vulnerable dogs.

show abstract

Section: Discussionsupporting

confidence: 90%

“…Xylazine is an alpha2-adrenoceptor agonist that is used for premedication, sedation, and analgesia in small animal practice [ 32 ]. It has marked anesthetic effect [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of various surgical procedures on biochemical parameters of Nigerian dogs and their clinical implications

2018

View full text Add to dashboard Cite

show abstract

“…It was possibly due to pooling of erythrocytes in to spleen due to decreased in sympathetic stimulation or hemodilution. Our results are in accordance with the (Jena et al, 2014). However, the values of white blood cells nonsignificantly increased (P>0.05) in xylazine-propofol receiving group as compared to diazepam-propofol and medetomidine propofol group.…”

Section: Respiratory Rate Depressionsupporting

confidence: 91%

“…As the previous studies explained that medetomidine alone cannot produce prolonged and rapid analgesia (Baker et al, 2011) therefore this might be due to the synergestic effect of medetomidine along with propofol. Medetomidine has increased specificity for the alpha-2 receptor, and increased analgesic potency compared to xylazine (Jena et al, 2014). Medetomidine is preferred over xylazine in dogs (Lemke, 2007).…”

mentioning

confidence: 99%

Clinico-biochemical study on different pre-anesthetic drugs combined with propofol for neutering dogs

Aslam

Akhtar

Khan

et al. 2019

IJAR

View full text Add to dashboard Cite

The objective of present study was to select the best pre-anesthetic to be used in combination with propofol for neutering dogs. A prospective randomized study was conducted on 18 clinical cases of mongrel dogs admitted for neutering were subjected in to three groups (n=6). In group A (xylazine @ 2.2 mg/kg), group B (diazepam@ 0.25 mg/kg) and group C (medetomidine @ 40 µg/kg body weight), were injected intramuscular as preanesthetics. After 3-5 minutes of pre-anesthetic, the propofol injection @ 6 mg/kg of body weight was administered intravenous as anesthetic drug in all three groups. Analgesia was tested by the presence or absence of following reflexes - tail pricking, toes pinch, pedal reflex and patellar reflex. Rapid onset (9.13 ± 1.41 minutes) and long duration (59.67± 5.50 minutes) of analgesia was observed in group C compared other groups (onset 13.661±1.72 A, 20.16 ± 1.75 B minutes) and duration of analgesia (48.56 ± 4.61 A and 40.66± 5.46 B minutes). CBC, ALT, AST, ALP and blood urea nitrogen values were non-significantly (P e” 0.5) same within and between all three groups. There was significant (P d” 0.5) increase in ALT, AST, ALP, BUN and serum creatinine in group B at 24 hours interval. The results of our study showed that there was non significant decrease (P e” 0.5) in Hb and total erythrocytes count while non-significant increase (P e” 0.5) in total leukocyte count was noted in all three groups. The results showed that Medetomidine HCl in combination with propofol produce, rapid onset, and long duration of analgesia, with rapid and smooth recovery and no effects on haematological parameters of dogs.

show abstract

“…The findings of the present study concurred with Sankar et al (2011) who had also observed a decrease in Hb, PCV, TEC, monocytes, eosinophil and neutrophilia during ketamine or propofol anaesthesia in acepromazine-xylazine premedicated dogs. Other workers are also reported similar results during the continuous infusion of propofol (Jena et al 2014, Ratnesh et al 2014, ketofol (Kumar et al 2014) and ketamine anaesthesia (Venugopal et al 2002) in dogs. The decreasing trend of haematological parameters in the present experiment might be due to the splenic pooling of erythrocytes that occur with most of the other anaesthetics.…”

Section: Haematological Observationsmentioning

confidence: 61%

Effects of Propofol, Ketamine and their Combination (ketofol) as Total Intravenous Anesthesia (TIVA) on Haematological, Serum Biochemical and Hormonal Profile in the Surgical Management of Canine Patients

Saikia¹,

Sarma²,

Sarma³

2021

IJAR

View full text Add to dashboard Cite

Background: The non-availability of the sophisticated anaesthetic machine and the necessary equipment to administer inhalant anaesthetic in the field hospitals make their use practically unfeasible for the field veterinarians. Therefore, the present study was undertaken to evaluate the effect of propofol, ketamine and their combination ‘Ketofol’ as a TIVA on certain haematological, serum biochemical and hormonal profiles in atropine and xylazine premedicated dogs. Methods: The study was conducted in eighteen clinical cases of dogs of either sex. The animals were randomly divided into three groups with six animals in each group. All the three groups were premedicated with Atropine sulphate @ 0.04mg/kg body weight and xylazine HCl @ 0.5mg/kg body weight intramuscularly. In group-I, propofol @ 5mg/kg body weight, in group-II, ketamine @ 5mg/kg body weight and in group-III, ketofol @ 4mg/kg body weight was administered intravenously for induction after 15 minutes of pre-anesthetic administration. Surgical anaesthesia was maintained for 90 minutes in all three groups viz. group-I, group-II and group-III with propofol @ 2.5mg/kg. b.w., ketamine @ 2.5mg/kg b.wt. and ketofol @ 2mg/kg b.wt. respectively by intermittent bolus injection (IBI) technique. Haematological, serum biochemical and hormonal profile were evaluated before administration of the anaesthetic agent (0 minutes) then at 15, 30, 60 and 90 minutes during and after administration of anaesthetic agents. Result: The study revealed that Hb, PCV and TEC were significantly decreased in all the groups at 60 mints and 30 mints respectively. The biochemical evaluation revealed that blood glucose level was significantly increased in all the groups until the end of the experiment. BUN and creatinine value was a significant increase in group-I and group-II than group-III at different time intervals up to the end of the experiment. In all the groups’ alanine aminotransferase (ALT) values significantly increased up to 60th minutes during TIVA whereas AST value was significantly increased in group-II at 30th and 60th minute of the experiment in compare to group-I and group-III. A higher level of cortisol values was recorded in group-I animals for the entire period of observation. There were no changes observed in the case of T3. Transient variables of haemato-biochemical have been reported following propofol, ketamine and their combination (ketofol) as total intravenous anaesthesia (TIVA). Thus, it has been concluded that diligent monitorization and electrolyte support are essential during the period of anaesthesia.

show abstract

Clinical evaluation of total intravenous anaesthesia using xylazine or dexmedetomidine with propofol in surgical management of canine patients

Cited by 17 publications

References 33 publications

Effects of various surgical procedures on biochemical parameters of Nigerian dogs and their clinical implications

Effects of various surgical procedures on biochemical parameters of Nigerian dogs and their clinical implications

Clinico-biochemical study on different pre-anesthetic drugs combined with propofol for neutering dogs

Effects of Propofol, Ketamine and their Combination (ketofol) as Total Intravenous Anesthesia (TIVA) on Haematological, Serum Biochemical and Hormonal Profile in the Surgical Management of Canine Patients

Contact Info

Product

Resources

About