Clinical evaluation of transcatheter arterial embolization combined with propranolol orally treatment of infantile hepatic hemangioma

Wang, Liang; Li, Jing; Song, Dan; Guo, Lei

doi:10.1007/s00383-022-05143-w

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…11 Mild symptom IHH of fifty-six patients with propranolol monotherapy without a description of efficacy. 14 Meanwhile, in a single center-based 30-year study, 39% to 47% of asymptomatic patients received expectant treatment but did not describe the age of tumor reduction or regression. 15 Even IHH with coagulopathy shows an excellent response and tolerance to propranolol.…”

Section: Discussionmentioning

confidence: 99%

“…The median duration of propranolol therapy for symptomatic IHH was 24.0 months (range 4.0–30.0) 11 . Mild symptom IHH of fifty‐six patients with propranolol monotherapy without a description of efficacy 14 . Meanwhile, in a single center‐based 30‐year study, 39% to 47% of asymptomatic patients received expectant treatment but did not describe the age of tumor reduction or regression 15 .…”

Section: Discussionmentioning

confidence: 99%

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Clinical features of cutaneous infantile hemangioma combined with asymptomatic infantile hepatic hemangioma and efficacy of propranolol treatment

et al. 2023

J of Cosmetic Dermatology

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IntroductionInfantile hepatic hemangioma (IHH) is a common liver tumor in infants and shares the same characteristics as cutaneous infantile hemangioma (IH). Propranolol is effective for symptomatic IHH. The clinical features between cutaneous IH and IHH, and treatment efficacy of IHH (smaller than 4 cm) is unclear. To evaluate the correlation of clinical features between cutaneous IH and IHH, as well as efficacy of systemic propranolol in the treatment of cutaneous IH combined with IHH.Materials and MethodsThe clinical data of infants with complicated cutaneous IH combined with IHH treated with systemic propranolol (1.5 ~ 2 mg/(kg d)) from January 2011 to October 2020 were retrospectively analyzed.ResultsForty‐five cases with IHH combined with complicated cutaneous IH were reviewed. Single cutaneous IH is more likely to be combined with focal IHH, cutaneous IH greater than 5, more likely to be combined with multiple IHH (Pearson = 0.546, p < 0.01). The mean age of focal and multiple IHH regression was 11.93 ± 14.42 months and 10.20 ± 9.15 months, respectively.ConclusionsThe number of cutaneous IH were correlated with the number of IHH. There was no difference in the age of complete remission for focal and multiple IHH.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical features of cutaneous infantile hemangioma combined with asymptomatic infantile hepatic hemangioma and efficacy of propranolol treatment

et al. 2023

J of Cosmetic Dermatology

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“…Surgical or radiological intervention should be promptly performed when life-threatening symptoms progress after medical treatment or malignancy was present. Hepatic artery embolization (HAE) or Hepatic artery ligation (HAL) is an effective alternative approach to decrease shunts and counteracts cardiac failure ( 30 ). Orthotopic liver transplantation may also be chosen for patients with DIHH because total hepatectomy cannot be sustained ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

Diffuse infantile hepatic hemangioma successfully treated with propranolol orally: a case report and literature review

Li,

Wu,

Dong

et al. 2024

Front. Oncol.

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BackgroundInfantile hepatic hemangioma (IHH) is a common vascular, fast-growing hepatic tumor that is usually accompanied by multiple cutaneous hemangiomas. Diffuse IHH (DIHH) is a rare type of IHH that exhibits many tumors with nearly complete hepatic parenchymal replacement. At present, there is no specific standardized treatment plan for DIHH. Herein, we present the case of a 2-month-old girl with DIHH and without cutaneous hemangioma who achieved complete remission after undergoing propranolol monotherapy.Case presentationThe infant with low birth weight was presented to the pediatric department with a 2-month history of persistent vomiting and feeding difficulty. Ultrasonography and abdominal magnetic resonance imaging revealed hepatomegaly and diffused intrahepatic lesions. A computed tomography-guided percutaneous liver biopsy was performed, and the pathological examination suggested the diagnosis was DIHH. The patient exhibited remarkably response to an increasing dose of oral propranolol, from 0.5 mg/kg to 2 mg/kg every day. The intrahepatic lesions were almost completely regressed after one year of treatment and no distinct adverse reaction was observed.ConclusionDIHH can induce life-threatening complications that require prompt interventions. Propranolol monotherapy can be an effective and safe first-line treatment strategy for DIHH.

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Infantile Hepatic Hemangioma: A Novel Approach Using Propranolol and Transarterial Embolization

Kaplish,

Vagha,

Lohiya

et al. 2024

Cureus

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Benign vascular tumors, or hemangiomas, are common in young children. The most frequent way to identify them on the skin is as bright red surface lesions, although they can also be detected deeper as subcutaneous lesions. Visceral involvement, particularly of the liver, is commonly observed in patients with multiple cutaneous hemangiomas. Since most hemangiomas are self-limited, they can be clinically monitored. Despite this, hepatic hemangiomas can result in significant consequences, such as severe hepatomegaly, which can induce abdominal compartment syndrome, inadequate ventilation, and renal vein compression, as well as significant arteriovenous shunts that compromise the functioning of the heart. Depending on the patient's findings, management may range from routine follow-up to liver transplantation. Here, we present a case of hypothyroidism, hepatomegaly, and cardiac failure in a two-month-old female newborn with infantile hepatic hemangioma. The patient's symptoms were managed with the use of levothyroxine, propranolol, and transcatheter arterial embolization (TAE).

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Clinical evaluation of transcatheter arterial embolization combined with propranolol orally treatment of infantile hepatic hemangioma

Cited by 3 publications

References 29 publications

Clinical features of cutaneous infantile hemangioma combined with asymptomatic infantile hepatic hemangioma and efficacy of propranolol treatment

Clinical features of cutaneous infantile hemangioma combined with asymptomatic infantile hepatic hemangioma and efficacy of propranolol treatment

Diffuse infantile hepatic hemangioma successfully treated with propranolol orally: a case report and literature review

Infantile Hepatic Hemangioma: A Novel Approach Using Propranolol and Transarterial Embolization

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