Aim: This study aimed to evaluate the clinical performance and occlusal wear resistance of nano- zirconia reinforced glass ionomer restorations in comparison to nano-hybrid resin composite restorations in proximal cavities. Material and Method: This randomized clinical trial was conducted on thirty-two patients who had proximal carious lesions in posterior teeth. Participants were randomly allocated into two groups (n=16 for each group) in which they received either; Nano zirconia reinforced glass ionomer restorations (Zirconomer Improved, Shofu, Japan) or Conventional nano hybrid resin composite (Filtek Z250 XT, 3M ESPE, USA), all materials were applied according to manufacturers’ instructions. Restorations were evaluated at baseline (immediately), after six months, and after 12 months by two blinded assessors using modified USPHS criteria measuring (postoperative hypersensitivity, secondary caries, gross fracture, color match, cavo-surface marginal discoloration, marginal integrity, proximal contact and wear resistance). Data was analyzed using Medcalc software, intergroup comparisons between interventions was performed using the Chi-Squared test with statistical significance level set at (P ≤ 0.05) while intragroup at (P ≤ 0.016) after Bonferroni correction, relative risk was used to assess the clinical significance. Results: Intergroup comparison between both materials regarding USPHS criteria and wear resistance have shown no statistically significant difference within different follow up periods; baseline, 6 and 12 months respectively except for the color match shown significant difference with highly translucent nano zirconia reinforced GI. Intragroup comparison within highly translucent nano zirconia reinforced glass ionomer and within conventional resin composite regarding USPHS criteria have shown no statistically significant difference between different followup periods except for the wear resistance shown significant difference within highly translucent nano zirconia reinforced GI. Conclusion: Nano zirconia reinforced glass ionomer and Nano hybrid resin composite have a similar clinical performance and wear resistance after one year follow up.