Clinical evaluations of complete autologous fibrin glue, produced by the CryoSeal ® FS system, and polyglycolic acid sheets as wound coverings after oral surgery

Kouketsu, Atsumu; Nogami, Shinnosuke; Yamada-Fujiwara, Minami; Nagai, Hirokazu; Yamauchi, Kensuke; Mori, Shiro; Matsumoto, Hitoshi; Kawai, Tadashi; Matsui, Atsuo; Kataoka, Yuki; Satomi, Norihisa; Ezoe, Yushi; Abe, Satoko; Takeda, Yohei; Tone, Takeshi; Hirayama, Bunnichi; Kurobane, Tsuyoshi; Tashiro, Kazuki; Yanagisawa, Yuta; Takahashi, Tsuneo

doi:10.1016/j.jcms.2017.06.004

Cited by 14 publications

(4 citation statements)

References 24 publications

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“…Previous study showed that the oral adhesive bandages could promote half of the oral surgical wounds healing faster than the unbandaged wounds [ 6 ]. Another study found that covering wounds with autologous fibrin glue and polyglycolic acid sheets can provide long-term protection and significantly promote the healing of wounds [ 10 ]. In our study, the average 26.6 h of protection was still too short for the healing of extraction wounds.…”

Section: Discussionmentioning

confidence: 99%

The hemostatic and comforting effects of oral adhesive bandages in tooth extraction: a randomized controlled clinical study

Zhou,

Cai,

Zhao

2024

Clin Oral Invest

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Objectives To compare oral adhesive bandages with the classic compression method and evaluate the clinical efficacy of this wound dressing material in improving postoperative comfort, wound healing, and hemostasis in tooth extraction. Materials and methods The study was designed as a randomized controlled clinical trial. A total of 120 patients were recruited and randomly assigned to the study group and the control group. In the study group, oral adhesive bandages were used as wound dressing. In the control group, patients bit on cotton balls and gauze, as usual. Hemorrhage, comfort, and healing levels were evaluated at postoperative 1 h, 24 h, and 7 days. The adhesion time of the oral adhesive bandages was also recorded. Results The average adhesion time of the oral adhesive bandages was 26.6 h. At postoperative 1 and 24 h, the hemostatic levels of the oral adhesive bandage group were significantly higher than those of the control group. The oral adhesive bandage group also reported significantly higher comfort scores than the control group. Both groups had similar healing levels and side effects. But the mean score for wound healing was slightly higher in the oral adhesive bandage group. Conclusions Oral adhesive bandages were more effective than cotton balls and gauze in providing hemostatic and comfort effects on extraction wounds. Clinical relevance Oral adhesive bandages possess clinical value in the management of extraction wounds.

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Section: Discussionmentioning

confidence: 99%

The hemostatic and comforting effects of oral adhesive bandages in tooth extraction: a randomized controlled clinical study

Zhou,

Cai,

Zhao

2024

Clin Oral Invest

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“…As fibronectin, complement, and immunoglobulin are enriched in cryoprecipitate; [22] and the alcohol content in thrombin can suppress the growth of bacteria to maintain aseptic conditions, daily treatment would not be necessary for AFG therapy in the same way after surgery. [11,12] Currently, 3 volumes of AFG of at least 2 mL are prepared from 300 to 400 mL of blood and stored in a freezer for at least 4 weeks after preparation. Therefore, weekly hospital visits are considered sufficient for patients undergoing AFG therapy.…”

Section: Discussionmentioning

confidence: 99%

“…[10] It has been used postsurgically depending on its physical function. [11,12] Although the application of fibrin glues of autologous cryoprecipitate with xenogeneic or allogeneic thrombin for the fixation of skin grafts or as a scaffold for keratinocytes on chronic skin ulcer have been confirmed, the sole effect of the fibrin glue on skin ulcers remains controversial. [13,14] Because AFG is prepared more mildly than commercial products that use ethanol for fractionation, its biological components remain unaltered.…”

Section: Introductionmentioning

confidence: 99%

Treatment of dermal ulcer with autologous fibrin glue: Two case reports of an exploratory prospective pilot study

Kawamoto,

Shinkawa,

Fujiwara

et al. 2023

Medicine

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Introduction: The healing of recurrent and refractory skin ulcers requires a long time, during which there is risk of infection, and hospital admission is occasionally required for surgical or daily conservative treatment. Therefore, the development of promising treatments that promote faster, uneventful healing is a must. Composed of cryoprecipitate and thrombin, fibrin glue has a history of surgical use for preventing bleeding and spinal fluid leakage. Moreover, in-house cryoprecipitates contain higher concentrations of coagulation factors and cytokines that may enhance wound healing than commercially available products. However, the efficacy of completely autologous fibrin glue (AFG) in tissue repair has not yet been fully demonstrated. Patient concerns: This study aimed to evaluate the efficacy of AFG in the treatment of refractory skin ulcers in comparison with the conventional treatment. Diagnosis: Two patients with skin ulcer on their lower extremities due to trauma or scleroderma who showed resistance to conventional treatment were included in the study. Both study participants were diagnosed with refractory skin ulcer and were ineligible for autologous skin transplantation. Interventions: AFG was prepared following autologous blood donation using a Cryoseal® system. Subsequently, AFG was administered to 50% of the area of each ulcer and observed for 4 weeks in comparison with recombinant basic fibroblast growth factor with bucladesine sodium treatment that was administered to the rest of the ulcer. Outcomes: The skin ulcer after trauma in participant 1 showed better improvement in the AFG-treated area. Although AFG did not show superiority regarding the ulcer area of a patient with scleroderma, it guarded the continuous exudation from the edge of the swollen skin surrounding the ulcer. Conclusion: AFG showed effective and beneficial results for wound healing of refractory skin ulcer and prevented exudation without any severe adverse events.

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“…Its application varies from use in wound covering to maxillofacial surgery and all these various gels/glues have different compositions of blood, with PRP forming the main component. 18 – 22 PRP contains growth factors that can encourage the growth of cells. From this study, 5 times concentration was seen to reduce MSC proliferation at day 7 and day 14.…”

Section: Discussionmentioning

confidence: 99%

The development of a novel autologous blood glue aiming to improve osseointegration in the bone-implant interface

Sanghani-Kerai

Coathup

Brown

et al. 2020

Bone & Joint Research

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Aims For cementless implants, stability is initially attained by an interference fit into the bone and osteo-integration may be encouraged by coating the implant with bioactive substances. Blood based autologous glue provides an easy, cost-effective way of obtaining high concentrations of growth factors for tissue healing and regeneration with the intention of spraying it onto the implant surface during surgery. The aim of this study was to incorporate nucleated cells from autologous bone marrow (BM) aspirate into gels made from the patient’s own blood, and to investigate the effects of incorporating three different concentrations of platelet rich plasma (PRP) on the proliferation and viability of the cells in the gel. Methods The autologous blood glue (ABG) that constituted 1.25, 2.5, and 5 times concentration PRP were made with and without equal volumes of BM nucleated cells. Proliferation, morphology, and viability of the cells in the glue was measured at days 7 and 14 and compared to cells seeded in fibrin glue. Results Overall, 2.5 times concentration of PRP in ABG was capable of supporting the maximum growth of cells isolated from the BM aspirate and maintain their characteristics. Irrespective of PRP concentration, cells in ABG had statistically significantly higher viability compared to cells in fibrin glue. Conclusion In vitro this novel autologous gel is more capable of supporting the growth of cells in its structure for up to 14 days, compared to commercially available fibrin-based sealants, and this difference was statistically significant. Cite this article: Bone Joint Res 2020;9(7):402–411.

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Clinical evaluations of complete autologous fibrin glue, produced by the CryoSeal ® FS system, and polyglycolic acid sheets as wound coverings after oral surgery

Cited by 14 publications

References 24 publications

The hemostatic and comforting effects of oral adhesive bandages in tooth extraction: a randomized controlled clinical study

The hemostatic and comforting effects of oral adhesive bandages in tooth extraction: a randomized controlled clinical study

Treatment of dermal ulcer with autologous fibrin glue: Two case reports of an exploratory prospective pilot study

The development of a novel autologous blood glue aiming to improve osseointegration in the bone-implant interface

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