Clinical evidence of three traditional Chinese medicine drugs and three herbal formulas for COVID-19: A systematic review and meta-analysis of the Chinese population

You, Liang-zhen; Dai, Qian-qian; Zhong, Xiao-ying; Yu, Dong-dong; Cui, He-rong; Kong, Yi-fan; Zhao, Meng-zhu; Zhang, Xin-yi; Xu, Qian-qian; Guan, Zhi-yue; Wei, Xu-xu; Zhang, Xue-cheng; Han, Song-jie; Liu, Wen-jing; Chen, Zhao; Zhang, Xiao-yu; Zhao, Chen; Jin, Ying-hui; Shang, Hong-cai

doi:10.1016/j.joim.2023.08.001

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…The health benefits of fermented foods has also been shown [35][36][37], which not only affect gut microbiota by the probiotic lactic acid bacteria, but also can improve the health status of the person directly by their anti-inflammatory, antioxidant, and other bioactive properties. Herbal medicines [38], supplements [39], and essential oils [40] may also function to prevent and improve the recovery from COVID-19 due to the phytochemicals with bioactive properties included in them.…”

Section: Introductionmentioning

confidence: 99%

Possible roles of phytochemicals with bioactive properties in the prevention of and recovery from COVID-19

Koyama,

Shields,

Heinbockel

et al. 2024

Preprint

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PurposeThere have been large geographical differences in the infection and death rates of COVID-19. Foods and beverages containing high amounts of phytochemicals with bioactive properties were suggested to prevent contracting, to limit the severity of, and to facilitate recovery from COVID-19. The goal of our study was to determine the correlation of the type of foods/beverages people consumed and the risk reduction of contracting COVID-19 and the recovery from COVID-19.MethodsWe developed an online survey that asked the participants whether they contracted COVID-19, their symptoms, time to recover, and their frequency of eating various types of foods/beverages. The survey was first developed in English and then translated into 10 different languages.ResultsThe participants who did not contract COVID-19 consumed vegetables, herbs/spices, and fermented foods/beverages significantly more than the participants who contracted COVID-19 and those who were not tested but became sick most likely from COVID-19. The geographic location of participants corresponded with the language of the survey, except for the English version, thus, nine out of the 10 language versions represented a country. Among the six countries (India, Iran, Italy, Japan, Russia, Spain) with over one hundred participants, we found that in India and Japan the people who contracted COVID-19 showed significantly shorter recovery time, and greater daily intake of vegetables, herbs/spices, and fermented foods/beverages was associated with faster recovery.ConclusionOur results suggest that phytochemical compounds included in the vegetables may have contributed in not only preventing contraction of COVID-19, but also accelerating their recovery. (249 words; EJN limit is 250 words)

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Section: Introductionmentioning

confidence: 99%

Possible roles of phytochemicals with bioactive properties in the prevention of and recovery from COVID-19

Koyama,

Shields,

Heinbockel

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The health benefits of fermented plant-based foods have also been shown ( 38–40 ), which not only affect gut microbiota by the probiotic lactic acid bacteria in them, but also can improve the health status of the person directly by the phytochemicals with anti-inflammatory, antioxidant, and other bioactive properties included in them. Herbal medicines ( 41 ), supplements ( 42 ), and essential oils ( 43 ) may also contribute to prevent and improve the recovery from COVID-19 due to the phytochemicals with bioactive properties included in them.…”

Section: Introductionmentioning

confidence: 99%

Possible roles of phytochemicals with bioactive properties in the prevention of and recovery from COVID-19

Koyama,

Joseph,

Shields

et al. 2024

Front. Nutr.

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IntroductionThere have been large geographical differences in the infection and death rates of COVID-19. Foods and beverages containing high amounts of phytochemicals with bioactive properties were suggested to prevent contracting and to facilitate recovery from COVID-19. The goal of our study was to determine the correlation of the type of foods/beverages people consumed and the risk reduction of contracting COVID-19 and the recovery from COVID-19.MethodsWe developed an online survey that asked the participants whether they contracted COVID-19, their symptoms, time to recover, and their frequency of eating various types of foods/beverages. The survey was developed in 10 different languages.ResultsThe participants who did not contract COVID-19 consumed vegetables, herbs/spices, and fermented foods/beverages significantly more than the participants who contracted COVID-19. Among the six countries (India/Iran/Italy/Japan/Russia/Spain) with over 100 participants and high correspondence between the location of the participants and the language of the survey, in India and Japan the people who contracted COVID-19 showed significantly shorter recovery time, and greater daily intake of vegetables, herbs/spices, and fermented foods/beverages was associated with faster recovery.ConclusionsOur results suggest that phytochemical compounds included in the vegetables may have contributed in not only preventing contraction of COVID-19, but also accelerating their recovery.

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Temporal, spatial and demographic distributions characteristics of COVID-19 symptom clusters from chinese medicine perspective: a systematic cross-sectional study in China from 2019 to 2023

Liu,

Song,

et al. 2024

Chin Med

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Background The subtypes diagnosis of disease symptom clusters, grounded in the theory of “Treatment in Accordance with Three Categories of Etiologic Factors” and International Classification of Diseases 11th Revision (ICD-11), is a vital strategy for Chinese Medicine (CM) in treating unknown respiratory infectious diseases. However, the classification of disease symptom clusters continues to depend on empirical observations and lacks robust scientific evidence. Consequently, this study seeks to explore the temporal, spatial and demographic distributions characteristics of Corona Virus Disease 2019 (COVID-19) symptom clusters in China. Methods PubMed, Web of Science, Science direct, WHO, Litcovid, CNKI databases were searched from inception until December 31, 2023. Optical character recognition technology and image recognition technology were employed to identify tables within the papers. Four researchers independently screened and extracted data, resolving conflicts through discussion. Heat mapping and hierarchical clustering techniques were utilized to analyze COVID-19 symptom clusters. Data analysis and visualization were conducted using R software (4.2.0), while the association analysis of symptom clusters was performed using Cytoscape (3.10.2). Results A total of 366 COVID-19 clinical trials with 86,972 cases including 66 clinical symptoms of 7 disease systems and other clinical manifestations in China were included. In temporal distribution, 63 symptoms centered around fatigue and 44 symptoms focused on chest tightness are characteristic of symptom clusters in spring and winter, respectively. With the addition of spatial distribution, the symptom clusters in middle and low latitudes during spring are characterized by 53 symptoms centered around fatigue and cough, and 51 symptoms focused on fatigue, respectively. During winter, the symptom clusters in middle and low latitudes are characterized by 38 symptoms centered around chest tightness and 37 symptoms focused on fever, respectively. When considering demographic distribution, the symptom clusters for < 50 years are characterized by fatigue as the core symptom in middle (44 symptoms)/low (28 symptoms) latitudes during spring and middle latitude (25 symptoms) during winter. For ≥ 50 years, the symptom clusters in middle latitude (49 symptoms) during spring and low latitudes (35 symptoms) during winter are centered around cough, while in low latitude (27 symptoms) focuses on diarrhea during spring, and middle latitude (35 symptoms) emphasizes both diarrhea and chest tightness during winter. Conclusion In summary, variations in symptom clusters and core symptoms of COVID-19 in temporal, spatial and demographic distributions in China offer a scientific rationale for the “Treatment in Accordance with Three Categories of Etiologic Factors” theory. These interesting findings prompt further investigation into CM patterns in the ICD-11, and suggest potential strategies for personalized precision treatment of COVID-19. High-quality clinical studies focusing on individual symptoms are warranted to enhance understanding of respiratory infectious diseases.

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Clinical evidence of three traditional Chinese medicine drugs and three herbal formulas for COVID-19: A systematic review and meta-analysis of the Chinese population

Cited by 3 publications

References 28 publications

Possible roles of phytochemicals with bioactive properties in the prevention of and recovery from COVID-19

Possible roles of phytochemicals with bioactive properties in the prevention of and recovery from COVID-19

Possible roles of phytochemicals with bioactive properties in the prevention of and recovery from COVID-19

Temporal, spatial and demographic distributions characteristics of COVID-19 symptom clusters from chinese medicine perspective: a systematic cross-sectional study in China from 2019 to 2023

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