Clinical evolution of chronic renal patients with HIV infection in replacement therapy

Saracho, Ramón; Escobar, Eduardo Martín; Farnés, Jordi Comas; Arcos, Emma; Blanca, Auxiliadora Mazuecos; Govantes, M.A. Gentil; Nuez, Pablo Castro de la; Zurriaga, Óscar; Alamar, Manuel Ferrer; Caamaño, Encarnación Bouzas; Falcón, Teresa García; Pérez, Jose Portolés; Calvo, José Antonio; Jambrina, C. Chamorro; Eguren, Íñigo Moina; Tomás, María Teresa Rodrigo de; Díez, José María Abad; Miret, José Ignacio Sánchez; Lipe, Rafael Álvarez; Tejeiro, Rafael Díaz; Alía, Inmaculada; Guinea, Marta Torres; Loza, Enma Huarte; Larrañaga, Marta Artamendi; Renedo, C. Fernandez; Fernández, Raquel; Álvarez, Emilio Sánchez; Torre, Ramón Alonso de la

doi:10.1016/j.nefroe.2015.11.004

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…While the incidence of ESRD has decreased, prevalence continues to rise. Recent data indicate 2 to 4-fold higher ESRD risk for those infected with HIV (11)(12)(13).…”

Section: Burden Of End-stage Organ Diseasementioning

confidence: 99%

Solid Organ Transplantation in HIV-Infected Recipients: History, Progress, and Frontiers

Werbel

Durand

2019

Curr HIV/AIDS Rep

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a) Purpose of review: What Is the goal of your paper? What questions did you seek to answer-End-stage organ disease prevalence is increasing among HIV-infected (HIV+) individuals. Trial and registry data confirm that solid organ transplantation (SOT) is efficacious in this population. Optimizing access to transplant and decreasing complications represent active frontiers. b) Recent findings: Summarize the latest research on your topic.-HIV+ recipients historically experienced 2-4 fold higher rejection. Integrase strand transferase inhibitors (INSTIs) minimize drug-interactions and may reduce rejection along with lymphodepleting induction immunosuppression. Hepatitis C virus (HCV) coinfection has been associated with inferior outcomes, yet direct-acting antivirals (DAAs) may mitigate this. Experience in South Africa and the US HIV Organ Policy Equity (HOPE) Act support HIV+ donor to HIV+ recipient (HIV D+/R +) transplantation. c) Summary: What answers did you find? What are the major takeaways/ conclusions of your examination? What's the impact on future research?-SOT is the optimal treatment for end-stage organ disease in HIV+ individuals. Recent advances include use of INSTIs and DAAs in transplant recipients, however strategies to improve access to transplant are needed. HIV D+/R+ transplantation is under investigation and may improve access and provide insights for HIV cure and pathogenesis research.

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“…While the incidence of ESRD has decreased, prevalence continues to rise. Recent data indicate 2 to 4-fold higher ESRD risk for those infected with HIV (11)(12)(13).…”

Section: Burden Of End-stage Organ Diseasementioning

confidence: 99%

Solid Organ Transplantation in HIV-Infected Recipients: History, Progress, and Frontiers

Werbel

Durand

2019

Curr HIV/AIDS Rep

View full text Add to dashboard Cite

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Role of kidney biomarkers [Kidney injury molecule-1, Calbindin, Interleukin-18 and Monocyte chemoattractant protein-1] in HIV associated pre-eclampsia

Eltounali

Moodley

Naicker

2017

Hypertension in Pregnancy

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Our results demonstrate an increase in the urinary level of kidney injury molecule-1 and calbindin in PE, implicating their possible value as biomarkers of kidney injury. We observed no differences in the levels of KIM-1, IL-18, MCP-1 and calbindin based on HIV status. We propose that studies with larger sample sizes using these markers be conducted to establish their use as markers of diagnosing kidney injury in PE.

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Clinical evolution of chronic renal patients with HIV infection in replacement therapy

Cited by 2 publications

References 19 publications

Solid Organ Transplantation in HIV-Infected Recipients: History, Progress, and Frontiers

Solid Organ Transplantation in HIV-Infected Recipients: History, Progress, and Frontiers

Role of kidney biomarkers [Kidney injury molecule-1, Calbindin, Interleukin-18 and Monocyte chemoattractant protein-1] in HIV associated pre-eclampsia

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