Clinical exercise interventions in prostate cancer patients—a systematic review of randomized controlled trials

Baumann, Freerk T.; Zopf, Eva M.; Bloch, Wilhelm

doi:10.1007/s00520-011-1271-0

Cited by 191 publications

(171 citation statements)

References 59 publications

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“…Fourteen systematic reviews found an improvement in qol for patients with cancer participating in an exercise intervention during the active treatment or post-treatment period 11,13,[15][16][17][18][19][20][21][22][23][24][25][26][27][28] . Of the sixteen studies involving patients in active treatment [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] , six demonstrated that, compared with the control group, the intervention group experienced significant improvements in qol 30,31,33,[38][39][40]43 .…”

Section: Quality Of Lifementioning

confidence: 99%

“…All systematic reviews found positive changes in both muscular and aerobic fitness 11,13,[15][16][17][18][19][20][21][22][23][24][25][26][27][28]55,56 . Of the sixteen rcts that measured muscular or aerobic fitness, or both 10,14,29,30,34,35,37,39,40,[44][45][46][47][48]52,54 , eleven found significant positive changes in the exercise groups 10,14,29,30,34,35,37,39,[44][45][46]48 .…”

Section: Muscular and Aerobic Fitnessmentioning

confidence: 99%

“…Four systematic reviews reported positive results for qol and muscular and aerobic fitness when the interventions were offered in a group or supervised setting compared with home-based or unsupervised exercise 15,18,22,55 . Two rcts compared various settings for interventions and found that the beneficial effects were greater when sessions were supervised, both in groups and by telephone 39,43 .…”

Section: Exercising In Group or Supervised Settingmentioning

confidence: 99%

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Exercise for People with Cancer: A Clinical Practice Guideline

et al. 2017

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Background Development of this guideline was undertaken by the Exercise for People with Cancer Guideline Development Group, a group organized by Cancer Care Ontario’s Program in Evidence-Based Care (pebc). The purpose of the guideline was to provide guidance for clinicians with respect to exercise for patients living with cancer, focusing on the benefits of specific types of exercise, recommendations about screening requirements for new referrals, and safety concerns.Methods Consistent with the pebc’s standardized approach, a systematic search was conducted for existing guidelines, and systematic literature searches were performed in medline and embase for both systematic reviews and primary literature. Content and methodology experts performed an internal review, which was followed by an external review by targeted experts and intended users.Results The search identified three guidelines, eighteen systematic reviews, and twenty-nine randomized controlled trials with relevance to the topic. The present guideline provides recommendations for the duration, frequency, and intensity of exercise appropriate for people living with cancer. It also provides recommendations for pre-exercise assessment, safety concerns, and delivery models.Conclusions There is sufficient evidence to show that exercise provides benefits in quality of life and muscular and aerobic fitness for people with cancer both during and after treatment, and that it does not cause harm. The present guideline is intended to support the Canadian Society for Exercise Physiology’s Canadian physical activity guidelines. The recommendations are intended for clinicians and institutions treating cancer patients in Ontario, and for policymakers and program planners involved in the delivery of exercise programs for cancer patients.

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Section: Quality Of Lifementioning

confidence: 99%

Section: Muscular and Aerobic Fitnessmentioning

confidence: 99%

Section: Exercising In Group or Supervised Settingmentioning

confidence: 99%

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Exercise for People with Cancer: A Clinical Practice Guideline

et al. 2017

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“…A targeted physical exercise program can, for example, positively influence the side effects of a prostate cancer treatment. A significant reduction of incontinence following a controlled exercise intervention has been demonstrated in several randomized studies [6,59].…”

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confidence: 92%

Role of physical activity in tumor patients and possible underlying mechanisms

Bloch

Zopf

Zimmer

et al. 2013

Eur Rev Aging Phys Act

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A growing knowledge regarding the influence of exercise on adverse physiologic outcomes associated with cancer and its treatment exists. Aside from its effects on psychological behavior, quality of life, and cancer-related fatigue, physical exercise can target physical and cardiorespiratory fitness, insulin regulation and metabolic syndrome, body weight and composition, and immune function in tumor patients. The increasing number of study results for different cancer types, which prove the positive influences of physical activity in cancer patients, changed the contradictory opinions which existed until the end of the last century. Although an increasing number of studies showing the positive effects of physical activity and more specifically of endurance and resistance training in cancer patients have been published, the underlying mechanisms are mostly unknown. Thus, we summarized the current knowledge of the effects of physical activity and specific training in different tumor entities with specific respect to the possible underlying mechanisms. Especially, the association between physical activity and (1) the improvement of fatigue and the role of free radicals in this process, (2) the counterbalance of tumor-induced cachexia, (3) the improvement of the immune system for supportive tumor treatment, and (4) the possible role of epigenetic modulation against tumor and tumor treatment-dependent adverse physiologic outcomes is focused.

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“…Modification of lifestyle factors has been shown to play a role in reducing the risk of developing colorectal cancer, including modifications in excess weight, poor diet, smoking, alcohol excess and physical inactivity [1][2][3][4][5][6]. However, given the difficulty in performing randomised controlled trials in lifestyle interventions in colorectal cancer, there is doubt about the feasibility of such interventions [7,8]. With this in mind, we have recently published a systematic review [9] which sought to collate the evidence for the feasibility of performing lifestyle factor interventions in patients with colorectal cancer, allowing conclusions on the short and long-term health benefits to be drawn.…”

mentioning

confidence: 99%

Commentary on Lifestyle Interventions Are Feasible in Patients with Colorectal Cancer with Potential Short-Term Health Benefits

Bryce¹,

Moug²

2017

J Comm Pub Health Nurs

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The problemWith the increasing incidence and heavy disease burden of colorectal cancer, there is a new need to improve the quality and length of survivorship in patients with this illness. The management of colorectal cancer involves multi-disciplinary working through multimodal treatment pathways and in itself has significant effects on the physical and psychological health of patients. Major surgery, adjuvant and neo-adjuvant chemotherapy and radiotherapy, and the possibility of a stoma are included in the list of challenges patients must overcome in their journey through the treatment of this illness.One such strategy to improve the quality and length of survivorship is lifestyle interventions. Modification of lifestyle factors has been shown to play a role in reducing the risk of developing colorectal cancer, including modifications in excess weight, poor diet, smoking, alcohol excess and physical inactivity [1][2][3][4][5][6]. However, given the difficulty in performing randomised controlled trials in lifestyle interventions in colorectal cancer, there is doubt about the feasibility of such interventions [7,8]. With this in mind, we have recently published a systematic review [9] which sought to collate the evidence for the feasibility of performing lifestyle factor interventions in patients with colorectal cancer, allowing conclusions on the short and long-term health benefits to be drawn. FeasibilityWe identified 14 randomised controlled trials investigating either physical activity or diet/excess body weight, or both, in patients with colorectal cancer -there were no randomised controlled trials investigating smoking or alcohol consumption [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. The interventions consisted mainly of telephone-prompted walking or cycling interventions and were mostly in the adjuvant setting. Dietary interventions focused on low-fat, high-fibre diets and were mostly part of multi-modal lifestyle interventions. We noted a low drop-out rate among these interventions, suggesting they are feasible. Although the majority were performed in the adjuvant setting, we also noted interventions being performed in the neo-adjuvant setting (including pre-habilitation) and even many years after completion of treatment. Short-term outcomes and crossover benefitsIn addition to a low drop-out rate among these randomised controlled trials we also noted shortterm improvements in both physical health (dietary quality, physical fitness) and quality of life. It should also be mentioned that many of these trials recruited from populations of patients with no one individual cancer, i.e. not specifically colorectal cancer. These findings reinforce the importance of correcting lifestyle factors not solely in colorectal cancer, but in many other cancers. Furthermore, given the well-documented and widely accepted role of lifestyle factors in the development of many other widespread diseases (cardiovascular disease, cerebrovascular disease, diabetes) [26], any lifestyle interventions to improv...

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Clinical exercise interventions in prostate cancer patients—a systematic review of randomized controlled trials

Cited by 191 publications

References 59 publications

Exercise for People with Cancer: A Clinical Practice Guideline

Exercise for People with Cancer: A Clinical Practice Guideline

Role of physical activity in tumor patients and possible underlying mechanisms

Commentary on Lifestyle Interventions Are Feasible in Patients with Colorectal Cancer with Potential Short-Term Health Benefits

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