Clinical Experience in Diagnosis and Treatment of Thyroid Disorders with Radioactive Iodine (Eight-Day Half-Life)

Radioiodine (131I) Therapy of Graves' Disease: Use of the New High Resolutional Ultrasonic Scanner for the Determination of the Accurate Weight of the Thyroid Gland.

“…In the analysis of various factors which may be related to the effect of radioiodine therapy in this study, a significant difference was observed in the gland size in hyperthyroid and euthyroid groups, and the incidence of euthyroidism was as high as 80% in patients with smaller glands but was extremely low in those with larger glands, indicating that a larger thyroid gland requires a larger radioiodine dose per gram of tissue than a smaller gland. Similar evidence has already been provided in many other reports (Werner et al, 1948;Balls et al, 1955;Goolden & Fraser 1969;Roudebush et al, 1977;Sridama et al, 1984), i n which, however, the gland size was estimated by palpation or scintigraphy. Therefore, it may be proposed that, to be satisfactory, the radiation dose should be graded according to the gland size even when the gland size is accurately estimated by ultrasound.…”

“…The results in the previous studies have varied from 31 to 79% (Werner et al, 1948 ;Cassidy waltes 1956;Franco & Quina 1956;BlomSmith & Wilson 1967;Rapoport et al, 1973;Cevallos et al, 1974;Reudebush et al, 1977;Sridama et al, 1984). In the analysis of various factors which may be related to the effect of radioiodine therapy in this study, a significant difference was observed in the gland size in hyperthyroid and euthyroid groups, and the incidence of euthyroidism was as high as 80% in patients with smaller glands but was extremely low in those with larger glands, indicating that a larger thyroid gland requires a larger radioiodine dose per gram of tissue than a smaller gland.…”

Radioiodine Therapy in Graves' Disease

“…Even if it were possible to guess accurately the weight of the thyroid, certain differences in therapeutic results would be observed due to variations in response to a given amount of radiation in individual patients. Hence, as has been reported by several groups (8)(9)(10)(11)(12)(13), myxedema may follow relatively small doses of radioiodine (in jac. per gram) while patients receiving much greater amounts do not go below normal metabolic levels.…”

“…The earliest reports to allow an even tentative appraisal of radioiodine therapy were published by the latter groups of authors in 1946 (6,7). In 1948, Soley and Miller (8,9), published their experiences and later in the same year two other groups recorded their results (Haines, Keat-ing, Power, Williams and Kelsey [10]; Werner, Quimby and Schmidt [11,12,13]). Prinzmetal and his coworkers (14,15) and Crile (16) dosimetry and biological effects of ionizing radiations should be handled by a radiologist.…”

A Study of the Iodine-Concentrating Function of the Thyroid After Treatment with Radioactive Iodine

“…In cases with a pathologically increased thyroid uptake of IlS1 we used the following rough dosage scheme: cases with a probably small thyroid volume (for instance operated cases without palpable goiter) 3-5 mC, cases with a normal or slightly enlarged thyroid volume 5-7 mC, cases with a moderately enlarged thyroid 7-10 mC and cases with a large goiter 10-15 mC. The euthyroid patients had no clinical or roentgenological signs of goiter and received [6][7][8] mC P. The doses were given by mouth. The radioactive iodine was delivered from Harwell and used within one week.…”