Clinical Experience in the Treatment of Different Vascular Lesions Using a Neodymium-Doped Yttrium Aluminum Garnet Laser

“…1c) 1,5,11,12,20,27,32,34,41,53,56–58,70,71,79,80,83,84,88,90,109,110,113,124,130,133,144,159,160. This overview therefore focuses on the causes of the therapeutic recalcitrance and presents several experimental engineering approaches, including (1) alterations in local hemodynamics, (2) concomitant laser treatment and dermo-vascular imaging, and (3) site-specific pharmaco-laser therapy, with which the therapeutic efficacy of recalcitrant PWSs may be improved.…”

Section: Introductionmentioning

confidence: 99%

An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains

et al. 2011

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During the last three decades, several laser systems, ancillary technologies, and treatment modalities have been developed for the treatment of port wine stains (PWSs). However, approximately half of the PWS patient population responds suboptimally to laser treatment. Consequently, novel treatment modalities and therapeutic techniques/strategies are required to improve PWS treatment efficacy. This overview therefore focuses on three distinct experimental approaches for the optimization of PWS laser treatment. The approaches are addressed from the perspective of mechanical engineering (the use of local hypobaric pressure to induce vasodilation in the laser-irradiated dermal microcirculation), optical engineering (laser-speckle imaging of post-treatment flow in laser-treated PWS skin), and biochemical engineering (light- and heat-activatable liposomal drug delivery systems to enhance the extent of post-irradiation vascular occlusion).

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“…As compared to the results of evaluation of other commonly used treatment methods for viral warts in the previous report, the results of our study indicate that LP-Nd:YAG is a safe and effective modality for the treatment of refractory warts, while causing minimal discomfort. 16 Though Han et al 16 reported extremely higher clearance rate for treating common warts (96%) but they had inevitable adverse effects under the protocol with longer duration previous papers 19 have described that the protocol with shorter duration (15 msec) and lower fluence (150-185 J/cm 2 ) are enough for desiccating the vessels for telangiectasia and spider angiomas and accomplished higher clearance rate with no remarkable side-effect. Therefore, we have decided that our protocol for treating the recalcitrant warts with a duration of approximately 15 msec and fluence of approximately 150-185 J/cm 2 is sufficient to damage the vasa vasorum of recalcitrant warts.…”

Section: Discussionmentioning

confidence: 99%

Long‐pulsed 1064‐nm neodymium:yttrium–aluminum–garnet laser treatment for refractory warts on hands and feet

Kimura

Takeuchi

Kinoshita

et al. 2014

The Journal of Dermatology

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Common warts (verruca vulgaris) are the most commonly seen benign cutaneous tumors. However, warts in the hands and feet regions often respond poorly to treatment, some are resistant to more than 6 months of treatment with currently available modalities, including cryotherapy, being defined as refractory warts. We investigated the usefulness of long-pulsed neodymium:yttrium-aluminum-garnet (LP-Nd:YAG) treatment for refractory warts. The clinical trial was conducted on 20 subjects (11 male, nine female) with a total of 34 lesions (periungual/subungual areas, plantar areas, fingers and/or toes). All the subjects suffered from refractory warts despite conventional treatments for more than 6 months. The patients were administrated up to six sessions of treatment, at intervals of 4 weeks between sessions, with an LP-Nd:YAG at a spot size of 5 mm, pulse duration of 15 msec and fluence of 150-185 J/cm 2 . Evaluation of the treatment results at 24 weeks after the initial treatment showed complete clearance of the refractory warts in 56% of the patients. Histological evaluation showed separation of the dermis and epidermis at the basement membrane with coagulated necrosis of the wart tissue in the lower epidermis, as well as coagulation and destruction of the blood vessels in the papillary dermis following the laser irradiation. No scarring, post-hyperpigmentary changes or serious adverse events were documented. Our preliminary results show that LP-Nd:YAG treatments are safe and effective for refractory warts of hands and feet, causing minimal discomfort, and is a viable treatment alternative.

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Clinical Experience in the Treatment of Different Vascular Lesions Using a Neodymium-Doped Yttrium Aluminum Garnet Laser

Abstract: A variable long-pulsed Nd:YAG laser was found to be effective in the treatment of different vascular lesions ranging from easy to difficult to treat. The authors have indicated no significant interest with commercial supporters.

Cited by 42 publications

References 17 publications

Basalzellkarzinome auf mit Radiotherapie vorbehandelten vaskulären Malformationen

Basalzellkarzinome auf mit Radiotherapie vorbehandelten vaskulären Malformationen

An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains

Long‐pulsed 1064‐nm neodymium:yttrium–aluminum–garnet laser treatment for refractory warts on hands and feet

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