Clinical experience of 2-hour I-131 thyroid uptake significance in considering the radioiodine Graves' disease treatment dose: A retrospective study

Al-Shammeri, Iman; Soveid, Mahmood; Al-Mohannadi, S.; Ballani, Nasser S.

doi:10.1016/j.radi.2014.12.011

Cited by 2 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MMI is one of the most common kinds of ATDs, which can inhibit the synthesis of peroxidase and limit the synthesis of TSH and FT 3 , thus improving the level of thyroid hormone (10). Numerous studies have shown that the concentration of drugs in the thyroid gland is closely related to the daily dose of the drug (14,17,18). Selenium is a necessary trace element of key importance for homeostasis of the human system, especially for the normal functioning of the immune system (19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study on the Beneficial Effects of the Additional Selenium Supplementation to Methimazole for Treating Patients with Graves? disease

Xu¹,

Wu²,

Hong³

et al. 2019

Turk J Med Sci

View full text Add to dashboard Cite

Backgroud/aim: The aim of this study was to assess the effect of a combination use of methimazole (MMI) and selenium (Se) in the treatment of Graves’ disease (GD). Materials and methods: A total of 103 newly-diagnosed hyperthyroidism patients were randomized to MMI and MMI+Se combination group. After treatment for six months, the levels of triiodothyronine (FT3), free thyroxine (FT4), thyrotrophin receptor antibody (TRAb), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TGAb) were observed. Besides, an in vitro culture model of thyroid cells was established and the protein expression and mRNA levels of TRAb, TPOAb and TGAb were determined by western blot and RT-PCR. Results: A significant decrease in the levels of FT3, FT4, TRAb, TPOAb and TGAb were observed in both groups along with a marked increase in TSH levels. Furthermore, the in vitro experiments showed that the protein expression and mRNA levels of TRAb, TPOAb and TGAb decreased significantly. Also, compared to the MMI group, there was a greater improvement of these indices in the MMI+Se group. Conclusion: We suggest that the combined use of MMI and Se could improve the thyroid activity in patients which may provide effective therapy for the treatment of GD in clinical settings. Key words: Graves’ disease; methimazole; selenium; TRAb; TPOAb; TGAb

show abstract

Section: Discussionmentioning

confidence: 99%

A Pilot Study on the Beneficial Effects of the Additional Selenium Supplementation to Methimazole for Treating Patients with Graves? disease

Xu¹,

Wu²,

Hong³

et al. 2019

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…In order to test the validity of our dosimetric model committed equivalent doses per unit intake (h Th ( 131 I)) were determined in the thyroid of various age groups of patients from the ingestion of 131 I by using Equation (9). Data obtained are shown in Table 4.…”

Section: Beta Committed Equivalent Dose To Thyroid Due To the Ingestion Of 131 I By Patientsmentioning

confidence: 99%

“…An example of thyroid scintigraphy image is given in Figure 6 for patient 1. Committed equivalent doses to thyroid (H Th ( 131 I)) from the ingestion of 131 I by the considered female patients were evaluated by using Equation (9). Data obtained are shown in Table 5.…”

Section: Beta Committed Equivalent Dose To Thyroid Due To the Ingestion Of 131 I By Patientsmentioning

confidence: 99%

“…131 I is widely used for diagnostic [3] and therapeutic [4] purposes. For many decades, radioactive iodine was orally administered to patients for the treatment of benign and malignant thyroid diseases [5][6][7][8][9]. Indeed, a major part of the administered radioiodine will concentrate in the thyroid gland; the emitted βparticles of short ranges will only damage thyroid cells without any harmful health effects to the neighboring organ tissues.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determination of Beta Radiation Dose to the Thyroid Gland from the Ingestion of <sup>131</sup>I by Patients

Misdaq¹,

Harrass²,

Karime³

et al. 2016

AJEP

View full text Add to dashboard Cite

Total activities due to the ingestion of 131 I were evaluated in different compartments of the human body of patients. It has been shown that the 131 I activity in urine of patients increases when the 131 I uptake decreases which could represent a source of radiation for their relatives when they leave hospitals. A new dosimetric model based on the specific betadose concept was developed for evaluating committed equivalent doses to thyroid due to 131 I uptake by different age groups of patients. Data obtained are in good agreement with those obtained by using the ICRP model for iodine. Committed equivalent dose to the thyroid gland is influenced by the mass of thyroid, 131 I uptake and energy of the emitted beta particles. In addition, 131 I uptake was measured by using a gamma camera and committed equivalent doses to the thyroid gland of female patients from the ingestion of 131 I for the treatment of hyperthyroidism diseases were evaluated. Data obtained by using our model and the ICRP ingestion dose coefficients are in good agreement with each other.

show abstract

Clinical experience of 2-hour I-131 thyroid uptake significance in considering the radioiodine Graves' disease treatment dose: A retrospective study

Cited by 2 publications

References 23 publications

A Pilot Study on the Beneficial Effects of the Additional Selenium Supplementation to Methimazole for Treating Patients with Graves? disease

A Pilot Study on the Beneficial Effects of the Additional Selenium Supplementation to Methimazole for Treating Patients with Graves? disease

Determination of Beta Radiation Dose to the Thyroid Gland from the Ingestion of <sup>131</sup>I by Patients

Contact Info

Product

Resources

About

Clinical experience of 2-hour I-131 thyroid uptake significance in considering the radioiodine Graves' disease treatment dose: A retrospective study

Cited by 2 publications

References 23 publications

A Pilot Study on the Beneficial Effects of the Additional Selenium Supplementation to Methimazole for Treating Patients with Graves? disease

A Pilot Study on the Beneficial Effects of the Additional Selenium Supplementation to Methimazole for Treating Patients with Graves? disease

Determination of Beta Radiation Dose to the Thyroid Gland from the Ingestion of &lt;sup&gt;131&lt;/sup&gt;I by Patients

Contact Info

Product

Resources

About

Determination of Beta Radiation Dose to the Thyroid Gland from the Ingestion of <sup>131</sup>I by Patients