Clinical experience of intracranial chordoma – A systematic review and meta-analysis of the literature

Leah, P.; Dower, Ashraf; Vescovi, Cristina; Mulcahy, Michael; Khawaja, Darweesh Al

doi:10.1016/j.jocn.2018.04.008

Cited by 23 publications

(22 citation statements)

References 40 publications

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“…In the early stages of a brain tumor, patients can remain asymptomatic. 2) Our patient had left-sided numbness and facial asymmetry, which was gradually getting worse over 6 months. However With regards to imaging modalities chosen for our patient, MRI was suggested by the radiologist as the first-line imaging modality because a brainstem tumor was suspected and also because MRI is highly accessible in our center.…”

Section: Discussionmentioning

confidence: 63%

“…2) A previous study reported a low risk for distant metastasis; however, the prognosis is relatively poor as there is a high local recurrent rate with a 5-year overall survival rate of 73%-78% and 5-year progression free survival of 50%. 2) This case reports an adolescent who was diagnosed with clival chordoma, and discusses the impact of the condition on his life. We also aim to highlight the importance of continuous follow-ups and shared care between primary and secondary care physicians to monitor tumor recurrence and provide long-term psychosocial support to an adolescent.…”

Section: Introductionmentioning

confidence: 97%

“…The incidence rate of chordoma peaked in patients aged 40-50 years. 2) Less than 5% of all chordoma arising in younger patients were diagnosed in those under 20 years of age. 3) Because of its slow growing nature, chordoma usually remains undetected until late stages of the disease.…”

Section: Introductionmentioning

confidence: 99%

“…3) Because of its slow growing nature, chordoma usually remains undetected until late stages of the disease. 2) The most common presenting symptoms for clival chordoma is diplopia, followed by cranial nerve palsies and headache. 2) A previous study reported a low risk for distant metastasis; however, the prognosis is relatively poor as there is a high local recurrent rate with a 5-year overall survival rate of 73%-78% and 5-year progression free survival of 50%.…”

Section: Introductionmentioning

confidence: 99%

“…2) The most common presenting symptoms for clival chordoma is diplopia, followed by cranial nerve palsies and headache. 2) A previous study reported a low risk for distant metastasis; however, the prognosis is relatively poor as there is a high local recurrent rate with a 5-year overall survival rate of 73%-78% and 5-year progression free survival of 50%. 2) This case reports an adolescent who was diagnosed with clival chordoma, and discusses the impact of the condition on his life.…”

Section: Introductionmentioning

confidence: 99%

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Clival Chordoma in an Adolescent: A Perspective from Primary Care

et al. 2020

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Clival chordoma is a rare malignant tumor of the brain that typically occurs in older adults. It has a high local recurrence rate and is hence associated with poor prognosis. Here, we report a case of an adolescent who presented with a 1-month history of worsening headache and blurring of vision, as well as a 6-month history of left-sided facial and body numbness. Clinical findings were consistent with left upper motor neuron lesion of the seventh cranial nerve with involvement of the fifth cranial nerve. He was also found to have a sixth cranial nerve palsy demonstrated by diplopia upon lateral gaze with no evidence of papilledema. Magnetic resonance imaging of the brain suggested clival chordoma. He was subsequently referred to the neurosurgical team, and he successfully underwent an endoscopic trans-sphenoidal surgery to excise the lesion. He recovered well, continued his follow-ups with the neurosurgical team, and showed good progress. He also attended regular follow-ups with his primary care physician to ensure ongoing psychosocial support and monitoring of his overall health status. This case demonstrates the importance of prompt identification and treatment of clival chordoma in an adolescent. Long-term follow-ups and shared care between primary and secondary care physicians are essential to monitor recurrence of tumor and to provide psychosocial support.

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Section: Discussionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 97%