Clinical experience using 8 MHZ radiofrequency capacitive hyperthermia in combination with radiotherapy: Results of a phase study

Lee, Chung K.; Song, Chang W.; Rhee, Juong G.; Foy, Julie A.; Levitt, Seymour H.

doi:10.1016/0360-3016(94)00608-n

Cited by 33 publications

(17 citation statements)

References 50 publications

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“…The risk of developing skin burns appears to be higher following treatment with a radiofrequency capacitive heating technique (5-16%) than with a radiative heating technique (0-3%) 14,24,26,27 . In the present study with strong superficial cooling, which was tolerated very well by patients, the skin burns were less frequent (5.9%).…”

Section: Discussionmentioning

confidence: 90%

“…Hyperthermia alone was continued in some cases after the end of radiotherapy. The physical features of the RF-8 clinical hyperthermia machine and thermal distribution characteristics in a phantom as well as in the human body when heating with this device have been reported previously 3,14 . In most cases, the upper electrodes were 25 cm and the lower electrodes 30 cm in diameter, and placed on opposite sides of the pelvic region.…”

Section: Hyperthermiamentioning

confidence: 97%

“…To the present authors' knowledge, in clinical reports with RF-8 for deep-seated tumour, the superficial tissue was cooled with 10-20 C saline or a water bolus only by the circulatory system of RF-8 when the tumour did not invade the subcutaneous tissue 2,3,14 . Since the conventional cooling ability of RF-8 cannot keep the overlay bolus circulation liquid less than 10 C under the situation of high-power RF output as more than 1000 W to achieve a good tumour temperature rise, the present authors previously developed the hyperthermia with their own external cooling unit and achieved strong superficial cooling 15 .…”

Section: Introductionmentioning

confidence: 99%

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Effect of 8-MHz radiofrequency-capacitive regional hyperthermia with strong superficial cooling for unresectable or recurrent colorectal cancer

Ohguri

Imada

Yahara

et al. 2004

International Journal of Hyperthermia

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A well-known disadvantage of a radiofrequency-capacitive device for deep-seated tumours is preferential heating of the subcutaneous fat tissue. The authors previously developed the hyperthermia with their own external cooling unit and achieved strong superficial cooling, and reported its usefulness for the reduction of the preferential heating. The purpose of the present study was to evaluate the effect of hyperthermia with strong superficial cooling on the treatment results for unresectable or recurrent colorectal cancers. From 1986 to 2002, 44 patients with primary unresectable or locally recurrent colorectal cancer treated with thermoradiotherapy were analysed retrospectively. The patients with obesity as a subcutaneous fat thickness more than 3 cm, a high age or other serious complications did not undergo therapy. The results were compared between 17 cases with strong superficial cooling treated after 1997 (Group A) and 27 cases without strong superficial cooling treated before 1996 (Group B). Significant differences in thermometry data of T(max), T(ave) and T(min) were noted between Groups A (45.3, 44.4 and 43.6 degrees C, respectively) and B (42.9, 42.0 and 41.1 degrees C, respectively) (p<0.01). Complete response plus partial response rates were better for Group A than for Group B (59 versus 26%, p = 0.05). Multivariate analysis by logistic regression to evaluate the effects of certain factors on complete response plus partial response was strongly correlated with strong superficial cooling (p<0.05). The median survival times for overall survival were 24.3 months for Group A and 17.1 months for Group B (p<0.05). Eight-megahertz radiofrequency-capacitive regional hyperthermia with strong superficial cooling is potentially useful for improving treatment results in unresectable or recurrent colorectal cancers.

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Section: Discussionmentioning

confidence: 90%

Section: Hyperthermiamentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of 8-MHz radiofrequency-capacitive regional hyperthermia with strong superficial cooling for unresectable or recurrent colorectal cancer

Ohguri

Imada

Yahara

et al. 2004

International Journal of Hyperthermia

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“…Radiofrequency (RF) hyperthermia using the Thermotron-RF8 has been performed mainly in Japan; however, it has two major issues: i) this modality has not been approved as a standardized treatment in oncology since each hyperthermic treatment is not of the same quality; and ii) there are risks for fatal hot spot or thermal runaway phenomena, which are induced by the RF treatment itself (16,17). …”

Section: Introductionmentioning

confidence: 99%

Chemoradiotherapy and concurrent radiofrequency thermal therapy to treat primary rectal cancer and prediction of treatment responses

et al. 2016

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The present study aimed to evaluate a previously reported predictive formula of output-limiting symptoms induced by radiofrequency (RF) to determine the efficacy of this neoadjuvant chemoradiation (NACR) and concurrent RF thermal therapy. The present study included 81 consecutive patients with confirmed diagnoses of rectal adenocarcinoma that was localized in the mid-low rectum (up to 12 cm from the anal verge) who received NACR [intensity-modulated radiotherapy (IMRT), 50 Gy/25 fractions, capecitabine 1,700 mg/m2/day for 5 days/week)] with concurrent thermal therapy (Thermotron-RF8, once a week for 5 weeks with 50 min irradiation). Patients with progressive disease (PD) did not receive RF outputs higher than the predicted value. Some patients who were predicted to receive more output in fact received more than the predicted output. In patients who were predicted to receive moderately higher outputs, 37.5% of the patients experienced pathological complete responses, which was the highest rate, while in those who did not receive more than the predicted output, 66.7% of the patients experienced PD, which was the highest rate in the present study. We speculate that RF thermal therapy may offset the chemoradiation effects in some patients. Adding thermal therapy as a multimodality therapy to NACR potentially affects patients with lower predicted outputs and actual observed outputs slightly higher than the predictive value. Our predictive equation for initial energy output, in which output-limiting symptoms can be used to predict treatment efficacy, consequently, can be used to decide whether to continue this treatment modality.

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“…Radiofrequency (RF) capacitive heating is widely used for the management of different human malignancies, including deep-seated tumors and its effectiveness has been reported by a number of investigators (1)(2)(3)(4). However, since magnetic waves do not entirely penetrate inside the patient's body, but partly circulate on the surface, spots where high voltage is accumulated may appear.…”

Section: Original Articlementioning

confidence: 99%

Relevance of a New Impedance Matching, or Subtrap, Method for the Reduction of Pain During Hyperthermia

et al. 1998

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Clinical experience using 8 MHZ radiofrequency capacitive hyperthermia in combination with radiotherapy: Results of a phase study

Cited by 33 publications

References 50 publications

Effect of 8-MHz radiofrequency-capacitive regional hyperthermia with strong superficial cooling for unresectable or recurrent colorectal cancer

Effect of 8-MHz radiofrequency-capacitive regional hyperthermia with strong superficial cooling for unresectable or recurrent colorectal cancer

Chemoradiotherapy and concurrent radiofrequency thermal therapy to treat primary rectal cancer and prediction of treatment responses

Relevance of a New Impedance Matching, or Subtrap, Method for the Reduction of Pain During Hyperthermia

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