Clinical experience with a new artificial bone graft: preliminary results of a prospective study

In vivo bone formation by human bone marrow stromal cells: Effect of carrier particle size and shape

“…When mixed with autologous bone marrow and bovine collagen, this HA/TCP swerves as a bone graft extender. It has been successfully used to treat acute long bone fractures (Kocialkowski et al, 1990) and delayed unions and nonunions of long bone fractures (Cornell et al, 1991). These HA/TCP particles range in size from 0.5-1.0 mm diameter.…”

Fabrication of Bio-Nanocomposite Nanofibers Mimicking the Mineralized Hard Tissues via Electrospinning Process

“…Therefore, in fields ranging from biology and chemistry to materials science and bioengineering a big challenge is being required to facilitate fabrication of bone and dentin-like biocomposite materials, which may allow the ingrowth of hard tissues with improving the mechanical properties with respect to the hard tissue regeneration. Several major requirements, which are critical in the development of biomaterials for hard tissue regeneration purpose, have to be taken into account: (1) the material must have a positive influence on the amount and quality of newly formed hard tissue, (2) the material must shorten the period of hard tissue formation and healing process of damaged tissues, (3) the material must not cause any adverse effects, namely inflammatory or toxic response, and (4) it must obtain mechanical properties that match with the natural hard tissues [8,9]. In recent years, particular attention has been paid to the biomimetic approaches, which allow us to mimic such nature-made bio-inorganic and bio-organic composite materials [10].…”

The effects of fibrinogen concentration on fibrin/atelocollagen composite gel: an in vitro and in vivo study in rabbit calvarial bone defect

“…However, aqueous atelocollagen has the disadvantages of low viscosity and insufficient physical strength when in contact with body fluids (Kocialkowski et al. ), resulting in a “flowing out” effect from the site of implantation. The cross‐linking of collagen provides a solution to the above issues.…”