Clinical experience with dihydroxyphenylalanine (DOPA) in depression

Klerman, Gerald L.; Schildkraut, Joseph J.; Hasenbush, Q L. Lee; Greenblatt, Milton; Friend, Dale G.

doi:10.1016/0022-3956(63)90004-9

Cited by 81 publications

(17 citation statements)

References 15 publications

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“…Because of this interest, we have in the last few years gathered important new information about the cerebral amines and their functions (68). Pharmacological treatments for depression so far suggest that the tricyclic compounds and the monoamine oxidase inhibitors increase the functionally free norepinephrine in the brain and that the antihypertensive drugs, reserpine and methyldopa, decrease free cerebral norepinephrine and cause clinical depression (34,62,11).…”

mentioning

confidence: 99%

Suppression Studies in Affective Disorders

McClure

Cleghorn

1968

Canadian Psychiatric Association Journal

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mentioning

confidence: 99%

Suppression Studies in Affective Disorders

McClure

Cleghorn

1968

Canadian Psychiatric Association Journal

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“…retarded behavior and low motor activity 4,25 , although this response was not observed by other researchers 12 .…”

mentioning

confidence: 38%

Privação de sono total na doença de Parkinson

Bertolucci

Andrade

Souza-Lima

et al. 1987

Arq. Neuro-Psiquiatr.

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“…Als Vorstufe der Katecholamine wurde in den klinischen Untersuchungen L-Dopa herangezogen (Klerman et al, 1963;Turner und Merlfs, 1964;Ingvarsson, 1965;Matussek et al, 1966Matussek et al, und 1970Goodwin et al, 1970;Malitz und Kanzler, 1972 Bunney, jr., R. W. Colburn, J. M. .Davis, J. N. Davis, D. M. Shaw, and A. J. Coppen: Noradrenatine, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid in hindbrains of suicidal patients. Lancet II, 805 (1968).…”

Section: Tryptophan-und Dopa-gabenunclassified

Biochemie der Depression

Matussek¹

1972

J. Neural Transmission

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SummaryZusammenfassungBiochemistry of Depression 1. The amount of 5-HIES in the nervous system of patients suffer from endogenous depression and mania is less than in healthy controls, i.e. there is a lack of functional 5-HT. However, this functional 5-HT deficit does not depend on the given phase as far as initial studies go. Till now it has not been completely clarified as to which degree a compensation of the functional 5-HT deficit, by the various means (pharmacotherapie and electroconvulsion) is needed to counteract the depression.2. Indications of lowered catecholamine turnover have been reported during the depressive phase or state after a misuse of amphetamines. It is, however, not sure whether the lower NE turnover is of peripheral or central origin and in how much the motor activity influences the results during the depressive or normothymic state.3. During the manic phase the catecholamine turnover especially the NA turnover is increased. The provocation of manic phases by means of dopa points to close ties of the catecholamines to mania.4. In the depression peripheral factors like hormones and certain enzyme systems are concerned in a different way, but a causative connection to the depression is not yet substantiated.In spite of a considerable progress in biochemical researches on depression which cleared up some important, mainly methodical, questions we are still far from solving the question regarding the biochemical mechanism of depression. The interpretation of partly contradictory results on urine and cerebro spinal fluid brings forth still great difficulties. Till now nobody approached to enlighten the reason of one or the other hypothetic metabolic disturbance in depression. Many processes even of the normal nervous system have not been understood and are far from being clear, particularly 224 N. Matussek: the control of cyclic events which is of special importance in the case of depression. Extensive efforts will be necessary to prove or disprove these simple and evident looking theories such as the 5-HT and NA hypotheses of depression.

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Clinical experience with dihydroxyphenylalanine (DOPA) in depression

Cited by 81 publications

References 15 publications

Suppression Studies in Affective Disorders

Suppression Studies in Affective Disorders

Privação de sono total na doença de Parkinson

Biochemie der Depression

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