Clinical Experience With Ergotamine Tartrate

Lichtman, S. S.

doi:10.1001/jama.1936.02770280058024

Cited by 10 publications

(3 citation statements)

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“…No deaths occurred during hibernation ; four patients died between twenty-four hours and three weeks after hibernation. 7. Two patients are still living seven and eight months respectively after hibernation ; they were entirely free from pain for three months and at present no narcotics are necessary to relieve their discomfort.…”

Section: Discussionmentioning

confidence: 95%

Experimental Hibernation of Metastatic Growths

Vaughn¹

1940

JAMA

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Section: Discussionmentioning

confidence: 95%

Experimental Hibernation of Metastatic Growths

Vaughn¹

1940

JAMA

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“…1,2 Substernal chest pain and discomfort suggestive of myocardial ischemia have been described with ergot preparations [ Table 1]. [3][4][5][6][7][8][9][10][11][12][13] Ergotamine taken orally in therapeutic doses has been associated with myocardial ischemia, 6,9,12 myocardial infarction, 4,13 cardiac arrest 4,14 and even sudden death 3 [ Table 1]. These complications have occurred with standard dosages more often than with overdosages.…”

Section: Discussionmentioning

confidence: 99%

Myocardial Ischemia Related to Ergot Alkaloids: A Case Report and Literature Review

et al. 1991

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Ergotamine tartrate and methysergide are widely used headache treatments with important vasoconstrictive properties. We report a 31-year-old man with cluster headaches who developed severe, prolonged myocardial ischemia following combination therapy with ergotamine tartrate and methysergide. We reviewed the cardiovascular complications of each agent alone and in combination. Given the pharmacologic similarity of these agents, we propose that they may have additive or synergistic cardiac toxicity, at least in vulnerable individuals. We recommend caution when these agents are used together.

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“…There have been several reports of myocardial ischaemia due to the use of ergotamine, for indications other than migraine, in patients with known heart disease (Labbe et al, 1929a;Lichtman, 1936;Scherf and Schlachman, 1948;McNerney and Leedham, 1950), and also in a case of thyrotoxicosis (Labbe, Justin-Besanion and Gouyen, 1929b). In a survey of the literature four cases of myocardial ischaemia occurring in previously healthy migraine sufferers have been found; in two of these angina occurred (Bailey Carter, 1940;Bemreiter, 1965), one developed a probable myocardial infarct (Fuchs and Blumenthal, 1950), and one a definite infarct (Goldfischer, 1960).…”

Section: Discussionmentioning

confidence: 99%