Clinical experience with netilmicin

Lane, A. Z.

doi:10.1093/jac/13.suppl_a.67

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The aminoglycoside and the cephalosporin, however, show a restricted tissue access, with distribution coefficient values of 0.20-0.33 L kg À1 and 0.18-0.31 L kg À1 , respectively, reported for man (Chung et al 1980;Campoli-Richards et al 1989;Nye et al 1989;Kovarik et al 1990;Barbhaiya et al 1992). Since all three antibiotics are used in clinical practice to combat respiratory infections (Lane 1984;Conway et al 1985;Hoepelman et al 1993;Leophonte et al 1993;McCabe et al 1996;Zhao et al 2000;Zhanel & Noreddin 2001;Huang et al 2002;Zhanel et al 2002), the kinetic profile in the lung must play an important role in the response to these drugs. Although some data about the concentration of levofloxacin, netilmicin and cefepime in lung tissue can be found in the literature (Fraschini et al 1988;Lee et al 1998;Breilh et al 2001;von Baum et al 2001), no comparative studies about the kinetic profile of these antibiotics in this body space are available.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of the disposition of levofloxacin, netilmicin and cefepime in the isolated rat lung

Martínez

Gandarillas

Lanao

et al. 2005

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

An experimental model of artificially perfused and mechanically ventilated lung has been applied to compare the kinetic behaviour of levofloxacin, cefepime and netilmicin in this body tissue. The study has been performed to explore the usefulness of the isolated lung technique in the pharmacokinetic field, particularly to study the disposition of antibiotics in pulmonary tissue. The lung was perfused with Krebs-Henseleit medium containing 3% bovine albumin at a flow rate of 5 mL min(-1). It was ventilated at 60 respirations/min with a 2-mL tidal volume of air previously humidified and warmed to 37 degrees C. The concentrations of the above antibiotics were determined by HPLC techniques and the outflow curves were analysed by stochastic, as well as by model-dependent, methods. The results show pharmacokinetic differences among these antibiotics, which are in accordance with previously reported data, levofloxacin being the drug with the highest distribution coefficient in this tissue (1.25 +/- 0.14 vs 0.39 +/- 0.07 and 0.41 +/- 0.06 mL g(-1) for netilmicin and cefepime, respectively). Accordingly, the isolated lung of the rat, under the experimental conditions used here, constitutes an alternative model to be incorporated to pharmacokinetic studies with a great potential use for those drugs that show a pharmacological or toxicological action depending on the kinetic profile in the lung tissue.

show abstract

Section: Introductionmentioning

confidence: 99%

Comparative study of the disposition of levofloxacin, netilmicin and cefepime in the isolated rat lung

Martínez

Gandarillas

Lanao

et al. 2005

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…Netilmycin is the newest agent and is as effective as other aminoglycosides but is less toxic 10 , 11 , although the use of dosage nomograms and the careful monitoring of serum levels is essential to ensure minimum effects of toxicity and the maximum therapeutic benefit.…”

Section: Introductionmentioning

confidence: 99%

Antibiotics: a clinical update

Sheron

1986

Int J Clinical Practice

View full text Add to dashboard Cite

Twice Daily Netilmicin Therapy in Paediatric Patients with Systemic Infections

Bodino¹,

Lopez²,

Pérez³

1988

J Int Med Res

View full text Add to dashboard Cite

This open investigation evaluated twice daily administration of netilmicin in infants and children with systemic infections. Thirty-four patients aged 2-41 months, were enrolled; 28 and 34 were evaluable for efficacy and safety, respectively. Netilmicin was administered intravenously or intramuscularly every 12 h at a dosage of 2.0-4.4 mg/kg (mean 3.5 mg/kg) for 5-15 days (mean 11 days). Throughout the trial, signs and symptoms of infection were evaluated in conjunction with laboratory data to determine patients' clinical response; specimens from appropriate sites were cultured to determine bacteriological response; and laboratory tests were performed to monitor haematopoietic, hepatic and renal functions. Peak and trough serum netilmicin levels were measured during treatment. Clinical responses included complete resolution in 26/28 (93%) patients, improvement in 1/28 (4%) and failure in 1/28 (4%). Bacteriological responses included elimination of 34/36 (94%) pathogens and persistence of 1/36 (3%); response was indeterminate for 1/36 (3%). Peak serum netilmicin levels of 5.1-14.1 micrograms/ml and trough serum netilmicin values of 0.1-1.5 micrograms/ml remained within acceptable ranges during treatment. No clinically significant changes in haematopoietic, hepatic and renal functions were evident during the trial. Untoward reactions were limited to redness and/or induration at the administration site in 4/34 (12%) patients.

show abstract

Clinical experience with netilmicin

Cited by 4 publications

References 0 publications

Comparative study of the disposition of levofloxacin, netilmicin and cefepime in the isolated rat lung

Comparative study of the disposition of levofloxacin, netilmicin and cefepime in the isolated rat lung

Antibiotics: a clinical update

Twice Daily Netilmicin Therapy in Paediatric Patients with Systemic Infections

Contact Info

Product

Resources

About