“…In fact, recent literature suggests ventilation assessment using capnography in nonintubated patients undergoing sedation may improve practice by providing an "early warning system" for impending respiratory compromise and hypoxemia (Cacho et al, 2010;Lightdale et al, 2006;Soto, Fu, Vila, & Miguel, 2004;Vargo, 2000;Vargo et al, 2002). Current practice generally has an increased emphasis on pulse oximetry for all patients receiving sedation, perhaps enabling a false sense of security while increased PetCO 2 levels go undetected (DeWitt, 2001;Fu, Downs, Schweiger, Miguel, & Smith, 2004;Hutchison & Rodriguez, 2008;Maddox, Williams, Oglesby, Butler, & Colclasure, 2006). However, pulse oximetry does not measure ventilation and decreased arterial saturation (SaO 2 ) is often a late sign of patient deterioration (American Academy of Pediatrics, Committee on Drugs, 2002; American Society of Anesthesiologists Task Force on Sedation and Analgesia by non- Anesthesiologists, 2002;Greensmith & Aker, 1998;Lightdale et al, 2006).…”