Clinical experience with pefloxacin in patients with urinary tract infections

Pc, Chan; Ik, Cheng; Mk, Chan; Wong, Wai T.

doi:10.1111/j.1742-1241.1990.tb10098.x

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Peripheral sensory disturbances related to treatment with fluoroquinolones

Hedenmalm

Spigset

1996

J Antimicrob Chemother

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The symptoms and possible risk factors of peripheral sensory disturbances related to fluoroquinolones are reviewed on the basis of 37 reports submitted to the Swedish Adverse Drug Reactions Advisory Committee. In 25 patients (68%), symptoms occurred within 1 week after start of treatment. Paraesthesia was the most common complaint and occurred in 81% of the cases. Fifty-one per cent of the reports concerned numbness/hypoaesthesia, 27% pain/hyperaesthesia and 11% muscle weakness. Seventy-one per cent of the patients recovered within 2 weeks after drug discontinuation. Possible predisposing factors were impaired renal function, diabetes, lymphatic malignancy and treatment with another drug known to cause neuropathy.

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Peripheral sensory disturbances related to treatment with fluoroquinolones

Hedenmalm

Spigset

1996

J Antimicrob Chemother

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Pefloxacin

Charles¹

2010

Kucers' the Use of Antibiotics Sixth Edition

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Peripheral Neuropathy Associated with Fluoroquinolones

Cohen

2001

Ann Pharmacother

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These cases suggest a possible association between fluoroquinolone antibiotics and severe, long-term adverse effects involving the PNS as well as other organ systems. The severity of these cases may reflect a different population than typically reported to drug companies or MedWatch, which often originate from healthcare providers. In contrast, Internet Web sites may provide a forum for patients experiencing adverse effects that have not resolved promptly. Further study is warranted. Meanwhile the occurrence of PNS symptoms during fluoroquinolone therapy should prompt immediate discontinuation of the agent used.

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Clinical experience with pefloxacin in patients with urinary tract infections

Cited by 5 publications

References 10 publications

Peripheral sensory disturbances related to treatment with fluoroquinolones

Peripheral sensory disturbances related to treatment with fluoroquinolones

Pefloxacin

Peripheral Neuropathy Associated with Fluoroquinolones

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