Clinical experience with the Bicarbon heart valve prosthesis

Misawa, Yoshio; Saito, Tsutomu; Konishi, Hiroaki; Oki, Sadaaki; Kaminishi, Yuichiro; Sakano, Yasuhito; Morita, Hideki; Aizawa, Kei

doi:10.1186/1749-8090-2-8

Cited by 9 publications

(12 citation statements)

References 22 publications

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“…In addition, the rates of bleeding were between 0.52 % and 2.7 % per patient-year, and the 10-year freedom from bleeding ranged from 77 % to 96.4 %. Our previous reports concluded that the results obtained were similar to those for other mechanical valves associated with a low incidence of valve-related morbidity and mortality [ 1 , 2 ].…”

Section: Discussionsupporting

confidence: 69%

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Fifteen-year experience with the Bicarbon heart valve prosthesis in a single center

Misawa

Muraoka

Ohki

et al. 2015

J Cardiothorac Surg

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BackgroundThe purpose of this study was to evaluate retrospectively the clinical performance of the Bicarbon valve (Sorin Biomedica Cardio, Saluggia, Italy) implanted at our center in Japan.MethodsBetween January 1997 and December 2011, 415 patients in our institution were implanted with the Bicarbon valve. Nine of these recipients were excluded from the study because they had already undergone valve implantation and received a Bicarbon valve in a different position. The remaining patients were analyzed for evaluation of the postoperative clinical outcomes. Of the 406 patients (mean age 60.2 ± 11.7 years), 179 underwent aortic valve replacement (AVR), 149 mitral valve replacement (MVR), and 78 both aortic and mitral valve replacement (DVR).ResultsThere were 10 early deaths (2.5 %: 4 in the AVR group and 6 in the MVR group). Three hundred eighty-nine patients were followed up (95.8 % completeness of follow-up) with a mean follow-up of 6.6 ± 4.2 years overall (AVR 6.8 ± 4.2, MVR, 6.7 ± 4.4, and DVR 5.7 ± 3.4 years) and a cumulative follow-up of 2661 patient-years (1214, 1001, and 446 patient-years for AVR, MVR, and DVR, respectively). Ninety-nine patients died (3.7 % per patient-year: 22 valve-related and 77 valve-unrelated deaths). Survival at 10 years was 74.1 ± 4.0 % in the AVR group, 73.7 ± 4.2 % in the MVR group, and 61.0 ± 7.9 % in the DVR group. The linearized incidence of thromboembolic complications, bleeding complications, prosthetic valve endocarditis, paravalvular leaks, and sudden death in all patients was 0.5 %, 0.5 %, 0.2 %, 0.2 %, and 0.4 % per patient-year, respectively. The incidence of valve-related complications and reoperation was 1.6 % and 0.4 %, respectively. No other valve-related complications were observed.ConclusionsThe Bicarbon prosthetic heart valve has shown excellent clinical results and is associated with a low incidence of valve-related complications.

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Section: Discussionsupporting

confidence: 69%

“…The mid-term results of 105 patients with a Bicarbon valve as of the end of January 2000 and the prospective follow-up study of the same patients at the end of December 2005 have already been reported [ 1 , 2 ]. Clinical data from additional patients was evaluated on the basis of mortality and morbidity analysis.…”

Section: Methodsmentioning

confidence: 99%

Fifteen-year experience with the Bicarbon heart valve prosthesis in a single center

Misawa

Muraoka

Ohki

et al. 2015

J Cardiothorac Surg

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“…A variety of different carbon based materials has been previously described in ophthalmic (Barber et al 1980, Wickham et al 1983 and bone applications (Turgut et al, 2008;Aoki et al, 2009). Some have even reached clinical use (Borman et al, 1998;Lypka et al, 2007;Misawa et al, 2007;Abramowicz et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Commercial Bicarbon™ bileaflet valves (Sorin Biomedica Cardio, Saluggia, Italy), composed of two pyrolytic carbon leaflets hinged on a titanium alloy housing coated with a thin carbon layer (Carbofilm™) have been evaluated extensively in multicentre, long-term follow-up clinical studies (Borman et al, 1998;Misawa et al, 2007). The clinical data point out excellent features associated with a low incidence of valve-related complications.…”

Section: Introductionmentioning

confidence: 99%

Reticulated vitreous carbon: a useful material for cell adhesion and tissue invasion

Reyes²,

Sánchez³

et al. 2010

eCM

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Diverse carbon materials have been used for tissue engineering and clinical implant applications with varying success. In this study, commercially available reticulated vitreous carbon (RVC) foams were tested in vitro and in vivo for compatibility with primary cell adhesion and tissue repair. Pores sizes were determined as 279 ± 98 μm. No hydroxyapatite deposition was detected after immersion of the foams in simulated body fluid. Nonetheless, RVC provided an excellent support for adhesion of mesenchymal stem cells (MSCs) as well as primary chondrocytes without any surface pre-treatment. Live cell quantification revealed neutral behaviour of the material with plastic adhered chondrocytes but moderate cytotoxicity with MSCs. Yet, rabbit implanted foams exhibited good integration in subcutaneous pockets and most importantly, total defect repair in bone. Probably due to the stiffness of the material, incompatibility with cartilage regeneration was found. Interestingly and in contrast to several other carbon materials, we observed a total lack of foreign body reactions. Our results and its outstanding porous interconnectivity and availability within a wide range of pore sizes convert RVC into an attractive candidate for tissue engineering applications in a variety of bone models and for ex vivo cell expansion for regenerative medical applications.

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“…One likely candidate material for this purpose is carbon. In clinical applications, carbon is already used in biomaterials such as artificial heart valves due to its high biocompatibility 28, 29. The application of carbon fibers to biomaterials has been expected because they are strong and flexible 30.…”

Section: Introductionmentioning

confidence: 99%

Multigram Solution‐Phase Synthesis of Three Diastereomeric Tripeptidic Second‐Generation Dendrons Based on (2S,4S)‐, (2S,4R)‐, and (2R,4S)‐4‐Aminoprolines

Zhang

Schlüter

2007

Chemistry An Asian Journal

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Three diastereomeric second-generation (G2) dendrons were prepared by using (2S,4S)-, (2S,4R)-, and (2R,4S)-4-aminoprolines on the multigram scale with highly optimized and fully reproducible solution-phase methods. The peripheral 4-aminoproline branching units of all the dendrons have the 2S,4S configuration throughout, whereas those units at the focal point have the 2S,4S, 2S,4R, and 2R,4S configurations. These latter configurations led to the dendrons being named (2S,4S)-1, (2S,4R)-1, and (2R,4S)-1, respectively. The 4-aminoproline derivatives used in this study are new, although many closely related compounds exist. Their syntheses were optimized. The dendron assembly involved amide coupling, the efficiency of which was also optimized by employing the following well-known reagents: EDC/HOBt, DCC/HOSu, TBTA/HOBt, TBTU/HOBt, BOP/HOBt, pentafluorophenol, and PyBOP/HOBt. It was found that the use of PyBOP is by far the best for dendrons (2S,4S)-1 and (2R,4S)-1, and pentafluorophenol active ester is best for (2S,4R)-1. Because of their multigram scale, all couplings were done in solution instead of by solid-phase procedures. Purifications were, nevertheless, easy. The optical purities of the key intermediates as well as the three G2 dendrons were analyzed by chiral HPLC analysis. These novel, diastereomeric second-generation dendrons have a rather compact and conformationally highly rigid structure that makes them interesting candidates for applications, for example, in the field of dendronized polymers and in organocatalysis.

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Clinical experience with the Bicarbon heart valve prosthesis

Cited by 9 publications

References 22 publications

Fifteen-year experience with the Bicarbon heart valve prosthesis in a single center

Fifteen-year experience with the Bicarbon heart valve prosthesis in a single center

Reticulated vitreous carbon: a useful material for cell adhesion and tissue invasion

Multigram Solution‐Phase Synthesis of Three Diastereomeric Tripeptidic Second‐Generation Dendrons Based on (2S,4S)‐, (2S,4R)‐, and (2R,4S)‐4‐Aminoprolines

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