Clinical experience with the silicone tracheal prosthesis

Segmental tracheal reconstruction by 3D-printed scaffold: Pivotal role of asymmetrically porous membrane

“…8 In 1960, a prominent milestone in the history of artificial trachea development was the introduction of a silicone rubber prosthesis, which became commercially available in the 1970s and was used clinically for a short time. 4 However, because mucosal regeneration could not be expected on the inner lumen, formation of granulation tissue or dehiscence occurred at the interface between the prosthesis and the native trachea, usually within several months. 9 Although other porous type of scaffold has been substituted for the conventional materials, PCL has gained considerable attention as an optimal biomaterial in various applications.…”

Management of Laryngotracheobronchial Sequelae and Complications of Relapsing Polychondritis

“…However, in one series, progression of the disease was associated with four deaths in a group of five treated with an intraluminal stent. 20 The possible displacement of the stent may lead to an asphyxia1 crisis. The stent may erode through the tracheal wall into the innominate artery and cause sudden death from massive hemorrhage.…”

Tracheal reconstruction using chondrocytes seeded on a poly(l-lactic-co-glycolic acid)-fibrin/hyaluronan

“…8 For ideal tracheal replacements, materials and cells for the tracheal construct should be airtight, accepted by the host, induce minimal inflammatory reaction, be capable of molding into various sizes and configurations, be capable of incorporation into surrounding tissues, and should be impervious to fibroblastic and bacterial invasion. 9 Since the first successful results of tissue-engineered cartilage implantation in small tracheal defects of mice, 10 increasing evidence has indicated the potential of tissue-engineering techniques. 11 Bioengineered tracheas have been made using a wide variety of materials and methods.…”