Clinical factors affecting evoked magnetic fields in patients with Parkinson's disease

Naganuma, Ryoji; Yabe, Ichiro; Takeuchi, Megumi; Morishita, Kirari; Nakane, Shingo; Takase, Ryoken; Takahashi-Iwata, Ikuko; Matsushima, Masaaki; Otsuki, Mika; Shiraishi, Hiroaki; Sasaki, Hidenao

doi:10.1371/journal.pone.0232808

Cited by 2 publications

(4 citation statements)

References 37 publications

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“…When used in combination with cortical measures, these can disentangle whether observed visual deficits arise from the retina, along the visual pathway or cerebral cortex. A recent study investigating the characteristics of the VER in patients with Parkinson’s disease found increased latencies in the cortical components with no cortical conduction time delays, supporting the view that this phenomenon may originate in the retina or along the pathway 83 84. Furthermore, besides a conduction delay, several VER component latencies were increased and related to severity of other clinically relevant measures, including UPDRS motor scores and tests for visual selective attention 83.…”

Section: Methodsmentioning

confidence: 89%

“…1 0 0 , 1 0 1 Furthermore, besides a conduction delay, several VER component latencies were increased and related to severity of other clinically-relevant measures, including UPDRS motor scores and tests for visual selective attention. 100 These increased latencies were even more strongly related in patients with Lewy body dementia 102 and were linked to the presence of visual hallucinations. 103 Although it is now well established that visual deficits in Parkinson's disease patients relate to poorer outcomes, it is not yet clear whether these relate entirely to visual cortical dysfunction, or whether retinal changes are also predictive of Parkinson's dementia.…”

Section: Parkinson's Diseasementioning

confidence: 96%

“…A recent study investigating the characteristics of the VER in patients with Parkinson’s disease found increased latencies in the cortical components with no cortical conduction time delays; supporting the view that this phenomenon may originate in the retina or along the pathway. 100 , 101 Furthermore, besides a conduction delay, several VER component latencies were increased and related to severity of other clinically-relevant measures, including UPDRS motor scores and tests for visual selective attention. 100 These increased latencies were even more strongly related in patients with Lewy body dementia 102 and were linked to the presence of visual hallucinations.…”

Section: Dopaminergic Influences On the Electroretinogrammentioning

confidence: 99%

Section: Dopaminergic Influences On the Electroretinogrammentioning

confidence: 99%

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Structural and functional changes in the retina in Parkinson’s disease

Alves

Westner

Højlund

et al. 2023

J Neurol Neurosurg Psychiatry

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Parkinson’s disease is caused by degeneration of dopaminergic neurons, originating in thesubstantia nigra pars compactaand characterised by bradykinesia, rest tremor and rigidity. In addition, visual disorders and retinal abnormalities are often present and can be identified by decreased visual acuity, abnormal spatial contrast sensitivity or even difficulty in complex visual task completion. Because of their early onset in patients with de novo Parkinson’s disease, the anatomical retinal changes and electrophysiological modification could be valuable markers even at early stages of the disease. However, due to the concomitant occurrence of normal ageing, the relevance and specificity of these predictive values can be difficult to interpret. This review examines retinal dysfunction arising in Parkinson’s disease. We highlight the electrophysiological delays and decreased amplitude in the electroretinography recorded in patients and animal models. We relate this to coexisting anatomical changes such as retinal nerve fibre layer and macular thinning, measured using optical coherence tomography, and show that functional measures are more consistent overall than optical coherence-measured structural changes. We review the underlying chemical changes seen with loss of retinal dopaminergic neurons and the effect of levodopa treatment on the retina in Parkinson’s disease. Finally, we consider whether retinal abnormalities in Parkinson’s disease could have a role as potential markers of poorer outcomes and help stratify patients at early stages of the disease. We emphasise that retinal measures can be valuable, accessible and cost-effective methods in the early evaluation of Parkinson’s disease pathogenesis with potential for patient stratification.

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Section: Methodsmentioning

confidence: 89%

Section: Parkinson's Diseasementioning

confidence: 96%

Section: Dopaminergic Influences On the Electroretinogrammentioning

confidence: 99%

Section: Dopaminergic Influences On the Electroretinogrammentioning

confidence: 99%

See 2 more Smart Citations

Structural and functional changes in the retina in Parkinson’s disease

Alves

Westner

Højlund

et al. 2023

J Neurol Neurosurg Psychiatry

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Apathy and Anhedonia: Clinical and Neurophysiological Assessment of a Romanian Cohort

2021

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Background: Patients with Parkinson’s disease (PD) often have, besides the characteristic motor manifestations, a wide variety of non-motor symptoms. These include apathy and anhedonia, common issues in PD, which can be quantified with the help of evaluation scales recommended by the literature. There are sensory non-motor manifestations of PD, some of which are easy to detect through electrophysiological studies. Our aim was to investigate the possible association of apathy and anhedonia with the severity of the motor status in a sample of PD patients in Romania. We also examined the prevalence of latency changes in the P100 wave of visual evoked potentials (VEPs) and how they correlated with motor status, apathy, and anhedonia in PD patients. Methods: Thirty-four patients with PD participated in this study. All were assessed for motor status using the Unified Parkinson’s Disease Rating Scale (UPDRS) and were rated on the Hoehn and Yahr scales. The presence and severity of apathy and anhedonia were assessed using the Apathy Evaluation Scale (AES), the Dimensional Apathy Scale (DAS), the Lille Apathy Rating Scale (LARS), and the Snaith–Hamilton Pleasure Scale (SHAPS). The latency of the P100 wave of the VEP was measured in all the patients. Results: Apathy and anhedonia were common among the patients with PD (35% and 58.8%, respectively). The presence of apathy/anhedonia was correlated with the severity of motor symptoms, as assessed using the UPDRS scale (p < 0.001), and with the stage of the disease according to the Hoehn and Yahr scale (p < 0.001). A prolonged latency of the P100 wave of the VEP was observed among apathetic (p < 0.001)/anhedonic (p < 0.01) patients and those with increased disease severity (p < 0.001). Conclusion: Apathy and anhedonia are common in PD and may correlate with the severity of motor symptoms. There may be visual impairment in these patients, evidenced by a prolonged P100 latency, which correlates with the severity of disease. Significance: Scales for assessing apathy and anhedonia, as well as measuring VEP latency, could be useful in assessing the severity of disease.

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Clinical factors affecting evoked magnetic fields in patients with Parkinson's disease

Cited by 2 publications

References 37 publications

Structural and functional changes in the retina in Parkinson’s disease

Structural and functional changes in the retina in Parkinson’s disease

Apathy and Anhedonia: Clinical and Neurophysiological Assessment of a Romanian Cohort

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