Clinical Factors Associated with Arterial Stiffness in Chronic Kidney Disease

Yao, Jin; Dong, Zheyi; Wang, Qian; Li, Zhe; Zhang, Weiguang; Lin, Wenwen; Luo, Yayong; Li, Hangtian; Guo, Xinru; Zhang, Li; Cai, Guangyan; Shen, Weisong; Duan, Shuwei; Chen, Xiangmei

doi:10.3390/jcm12031077

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Studies focusing on the association between CKD-MBD markers and AS have shown conflicting results. In a cross-sectional study, serum calcium and phosphorus concentrations were not an independent predictor of AS among CKD patients [44]. Another small study showed that, in patients undergoing peritoneal dialysis, aortic PWV were not correlated with serum calcium, phosphorus, or iPTH levels [45].…”

Section: Discussionmentioning

confidence: 93%

Positive Association of Serum Galectin-3 with the Development of Aortic Stiffness of Patients on Peritoneal Dialysis

Huang

Huang²,

Lin

et al. 2023

JCM

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A novel cardiovascular stress biomarker known as galectin-3 might be useful for anticipating adverse cardiovascular outcomes. The objective of the current investigation was to assess the association between serum galectin-3 levels and aortic stiffness (AS) in 196 patients on peritoneal dialysis. An enzyme-linked immunosorbent examination and a cuff-based volumetric displacement were employed to determine the levels of serum galectin-3 and the carotid-femoral pulse wave velocity (cfPWV), respectively. The AS group had 48 patients in total (24.5%) with cfPWV greater than 10 m/s. The AS group, when compared with the group without AS, had a significantly higher prevalence of diabetes mellitus and hypertension in addition to greater fasting glucose levels, waist circumference, systolic blood pressure, and serum galectin-3 levels. Multivariate logistic and linear regression analysis demonstrated that serum glactin-3 levels, in addition to gender and age, were significantly and independently associated with cfPWV and AS. Serum galectin-3 levels were linked with AS, according to a receiver operating characteristic curve analysis, with an area under the curve of 0.648 (95% confidence interval, 0.576–0.714; p = 0.0018). In summary, there was a significant correlation between serum galectin-3 levels and cfPWV in patients undergoing peritoneal dialysis therapy for end-stage kidney disease.

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Section: Discussionmentioning

confidence: 93%

Positive Association of Serum Galectin-3 with the Development of Aortic Stiffness of Patients on Peritoneal Dialysis

Huang

Huang²,

Lin

et al. 2023

JCM

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“…AS is characterized by chronic structural modifications in the arterial wall expressed by elastin fragmentation and media calcification, but molecular changes in the intimal layer may also occur through the atherosclerotic inflammatory process [12,13].…”

Section: Introductionmentioning

confidence: 99%

Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients

Rusu,

Kacso,

Moldovan

et al. 2023

Diagnostics

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Cardiovascular diseases (CVD) are the first cause of chronic kidney disease (CKD) mortality. For personalized improved medicine, detecting correctable markers of CVD can be considered a priority. The aim of this study was the evaluation of the impact of nutritional, hormonal and inflammatory markers on brachial-ankle Pulse Wave Velocity (PWV) in pre-dialysis CKD patients. A cross-sectional observational study was conducted on 68 pre-dialysis CKD patients (median age of 69 years, 41.2% with diabetes mellitus, 52.9% male). Laboratory data were collected, including levels of prolactin, triiodothyronine, TGF α, IL-6, and IL-1β. The high values of brachial-ankle PWV were associated with reduced muscle mass (p = 0.001, r = −0.44), low levels of total cholesterol (p = 0.04, r = −0.26), triglycerides (p = 0.03, r = −0.31), triiodothyronine (p = 0.04, r = −0.24), and prolactin (p = 0.02, r = −0.27). High PWV was associated with advanced age (p < 0.001, r = 0.19). In the multivariate analysis, reduced muscle mass (p = 0.018), low levels of triiodothyronine (p = 0.002), and triglycerides (p = 0.049) were significant predictors of PWV, but age (p < 0.001) remained an important factor. In conclusion, reduced triiodothyronine together with markers of malnutrition and age were associated with PWV in pre-dialysis CKD patients.

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Clinical Factors Associated with Arterial Stiffness in Chronic Kidney Disease

Cited by 2 publications

References 29 publications

Positive Association of Serum Galectin-3 with the Development of Aortic Stiffness of Patients on Peritoneal Dialysis

Positive Association of Serum Galectin-3 with the Development of Aortic Stiffness of Patients on Peritoneal Dialysis

Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients

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