Clinical Factors, But Not C-Reactive Protein, Predict Progression of Calcific Aortic-Valve Disease

Novaro, Gian M.; Katz, Ronit; Aviles, Ronnier J.; Gottdiener, John S.; Cushman, Mary; Psaty, Bruce M.; Otto, Catherine M; Griffin, Brian P.

doi:10.1016/j.jacc.2007.07.064

Cited by 180 publications

(118 citation statements)

References 38 publications

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“…4,6,20 However, prognostic factors are likely to differ between the early and late stages, and moreover, the Cardiovascular Health Study has shown the effects of ethnicity on CAVD pathogenesis. 6 This retrospective study analyzed data from Japanese patients and showed that early-stage subjects with mitral regurgitation, nonuse of ARBs or warfarin use tended to undergo progression of CAVD. In late-stage subjects, progression was associated with female gender, small LV cavity and low level of hemoglobin.…”

Section: Discussionmentioning

confidence: 99%

“…The group with early-stage CAVD comprised subjects with calcification on one or no leaflet and peak aortic transvalvular flow velocity o2 m s À1 (n¼157). 6,[17][18][19] The late-stage CAVD group comprised subjects with two or three calcified aortic valves and/or with peak aortic transvalvular flow velocity of X2 m s À1 (n¼399). Eleven patients had bicuspid aortic valve, and all met the criteria for late-stage CAVD.…”

Section: Methods Subjectsmentioning

confidence: 99%

“…2 Hypertension is a principal underlying disease, [3][4][5][6] and previous studies in Western countries have shown an association between several clinical factors and the presence and/or progression of CAVD. 3,6,7 The Cardiovascular Health Study showed that African-American ethnicity was associated with lower risk of CAVD progression. 6 Although several risk factors are shared between atherosclerotic diseases and CAVD, discrepancies in their pathogenesis have also been identified.…”

Section: Introductionmentioning

confidence: 99%

“…3,6,7 The Cardiovascular Health Study showed that African-American ethnicity was associated with lower risk of CAVD progression. 6 Although several risk factors are shared between atherosclerotic diseases and CAVD, discrepancies in their pathogenesis have also been identified. [8][9][10] These results highlight the necessity of investigating prognostic factors for incidence and progression of CAVD in Asian populations.…”

Section: Introductionmentioning

confidence: 99%

“…The JASS Retrospective Analysis is a retrospective study to investigate the prognostic factors for progression of CAVD in Japanese subjects. As previous studies in Western countries suggest that prognostic factors differ according to CAVD severity, 4,6,11 the study subjects were divided on the basis of the presence of early-vs. late-stage diseases.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic factors for progression of early- and late-stage calcific aortic valve disease in Japanese: The Japanese Aortic Stenosis Study (JASS) Retrospective Analysis

Yamamoto

Yoshida

et al. 2010

Hypertens Res

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Calcific aortic valve disease (CAVD) is the most common etiology of acquired valvular heart disease, and hypertension is a principal underlying disease. The Japanese Aortic Stenosis Study (JASS) Retrospective Analysis is a retrospective observational study to clarify the prognostic factors for progression of CAVD in Japanese. Data from 556 subjects who met the following criteria were analyzed: (1) X50 years old; (2) calcification in any aortic valve leaflet or peak aortic jet velocity X2 m s À1 on an echocardiographic study performed between July 2004 and June 2007; and (3) availability of earlier echocardiographic data from within the previous 2-5 years to assess the progression of CAVD. The subjects were divided into two groups according to CAVD severity on the preceding echocardiographic examination. In early-stage subjects with calcification in one or zero leaflets who were without aortic stenosis on the preceding echocardiographic study (n¼157), the prognostic factors for progression were the following: (1) no use of angiotensin receptor blockers (ARB) and (2) use of warfarin. In late-stage subjects with calcification in two or three leaflets and/or aortic stenosis on the preceding echocardiographic study (n¼399), progression was observed in females and in subjects with low hemoglobin and a concentric left ventricle. There was no relation between medications and changes in CAVD. Prognostic factors for the progression of CAVD were different between the early and late stages. Initiation of ARB treatment during the early stage may be effective, and we should be vigilant about progression of CAVD in patients treated with warfarin.

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Section: Discussionmentioning

confidence: 99%

Section: Methods Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic factors for progression of early- and late-stage calcific aortic valve disease in Japanese: The Japanese Aortic Stenosis Study (JASS) Retrospective Analysis

Yamamoto

Yoshida

et al. 2010

Hypertens Res

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Valvular Heart Disease and Infective Endocarditis

Malhotra

Dawkins

Prendergast

2012

Pathy's Principles and Practice of Geriatric Medicine

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Decreased expression of RPL15 and RPL18 exacerbated the calcification of valve interstitial cells during aortic valve calcification

Wang

Qin

Zhang

et al. 2023

Cell Biology International

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Calcific aortic valve disease (CAVD) is the most common valvular heart disease, with an increasing prevalence due to an aging population. The pathobiology of CAVD is a multifaceted and actively regulated process, but the detailed mechanisms have not been elucidated. The present study aims to identify the differentially expressed genes (DEGs) in calcified aortic valve tissues, and to analyze the correlation between DEGs and clinical features in CAVD patients. The DEGs were screened by microarray in normal and CAVD groups (n = 2 for each group), and confirmed by quantitative real‐time polymerase chain reaction in normal (n = 12) and calcified aortic valve tissues (n = 34). A total of 1048 DEGs were identified in calcified aortic valve tissues, including 227 upregulated mRNAs and 821 downregulated mRNAs. Based on multiple bioinformatic analyses, three 60S ribosomal subunit components (RPL15, RPL18, and RPL18A), and two 40S ribosomal subunit components (RPS15 and RPS21) were identified as the top 5 hub genes in the protein–protein interaction network of DEGs. The expression of RPL15 and RPL18 was also found significantly decreased in calcified aortic valve tissues (both p < .01), and negatively correlated with the osteogenic differentiation marker OPN in CAVD patients (both p < .01). Moreover, inhibition of RPL15 or RPL18 exacerbated the calcification of valve interstitial cells under osteogenic induction conditions. The present study proved that decreased expression of RPL15 and RPL18 was closely associated with aortic valve calcification, which provided valuable clues to find therapeutic targets for CAVD.

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Clinical Factors, But Not C-Reactive Protein, Predict Progression of Calcific Aortic-Valve Disease

Cited by 180 publications

References 38 publications

Prognostic factors for progression of early- and late-stage calcific aortic valve disease in Japanese: The Japanese Aortic Stenosis Study (JASS) Retrospective Analysis

Prognostic factors for progression of early- and late-stage calcific aortic valve disease in Japanese: The Japanese Aortic Stenosis Study (JASS) Retrospective Analysis

Valvular Heart Disease and Infective Endocarditis

Decreased expression of RPL15 and RPL18 exacerbated the calcification of valve interstitial cells during aortic valve calcification

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