Clinical failures of appropriately-treated methicillin-resistant Staphylococcus aureus infections

Abstract

We found a high rate of treatment failure in an urban population among patients who completed recommended therapy, largely with vancomycin alone. Failure in osteomyelitis was particularly common. High quality comparative studies of antibiotic regimens for MRSA infections, particularly osteomyelitis, are needed.

Emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Southeast Austria

“…From 1,7 The increase of CA-MRSA in 2005 was associated with the appearance of spa type t008, and spa type t622 in our region (Table 1). Spa type t008 is represented in most European countries and comprises the Archaic/Iberian/Irish clone, as well as more recently the USA300 MRSA.…”

Evaluation of Vancomycin in Combination with Piperacillin-Tazobactam or Oxacillin against Clinical Methicillin-Resistant Staphylococcus aureus Isolates and Vancomycin-Intermediate S. aureus Isolates In Vitro

“…Even with widespread clinical use of these regimens, little is known about how broad-spectrum ␤-lactams and VAN act in combination against MRSA. This is despite the well-documented decreased susceptibility of S. aureus to VAN and the positive correlation between S. aureus VAN susceptibility and patient outcomes (4)(5)(6)(7)(8)(9)(10). VAN treatment has also been associated with high clinical failure rates in patients with MRSA isolates susceptible to VAN (11,12).…”

Efficacy of Fosfomycin in Experimental Osteomyelitis Due to Methicillin-Resistant Staphylococcus aureus

“…The rising incidence of infections due to methicillin-resistant Staphylococcus aureus (MRSA) has considerably complicated the treatment of osteomyelitis and raised important issues relating to drug toxicity and development of antibiotic resistance during treatment (5,26).…”