“…The pose of the HoloLens is determined by a proprietary algorithm for Simultaneous localization and mapping (SLAM), which estimates the estates (i.e., position, orientation, linear accelerations, and angular velocities) of the headset with respect to the physical space by combining multi‐sensor data fusion techniques, e.g., inertial, depth, and visual cues. Recently, several studies have explored the possibility of using the Microsoft HoloLens in neurosurgery, reconstructive and plastic surgery, liver cancer surgery, endovascular surgery, and in telemedicine . In all these previously mentioned studies, the authors have not estimated the transformation between the physical and virtual reference frames.…”