Clinical Features and Diagnosis of Aquareovirus Infection

Zeng, Weiwei; Wang, Yingying; Wang, Qing; Wang, Yahui; Yin, Jun; Li, Yingying

doi:10.1007/978-981-16-1903-8_6

Cited by 1 publication

(2 citation statements)

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“…AqRVs can infect a wide variety of aquatic animals including grass carp ( Ctenopharyngodon idella ), Japanese flounder ( Paralichthys olivaceus ), adult fall Chinook salmon (FSCV) ( Oncorhynchus tshawytscha ) and Atlantic halibut ( Hippoglossus hippoglossus ) et al 12–15 Noteworthy, grass carp reovirus (GCRV), which belongs to AqRV‐C, is a common and severe pathogen for grass carp breeding industry in south‐China since it was firstly isolated from a diseased grass carp in 1983 16,17 . GCRV‐infected grass carp were characterised with clinical symptoms such as mild or severe petechial haemorrhage throughout the muscle, intestine and liver 18 . To date, lots of efforts have been made in exploring the factors affecting GCRV replication and infection, as well as multiple therapeutic vaccines design.…”

Section: Introductionmentioning

confidence: 99%

“…16,17 GCRV-infected grass carp were characterised with clinical symptoms such as mild or severe petechial haemorrhage throughout the muscle, intestine and liver. 18 To date, lots of efforts have been made in exploring the factors affecting GCRV replication and infection, as well as multiple therapeutic vaccines design. The chemically attenuated virus strain (GCHV-892) has been licenced in 2011 as the first legal vaccine for grass carp hemorrhagic disease (GCHD).…”

Section: Introductionmentioning

confidence: 99%

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Structure, function and immune evasion strategies of aquareoviruses, with focus on grass carp reovirus

Zhang

Chang

2023

Reviews in Aquaculture

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Aquareoviruses (AqRVs) can infect various wild or cultured bony fishes with serious muscle and viscera haemorrhage syndrome and have caused severe economic losses worldwide. Accumulating evidences have revealed the functions of viral proteins of AqRVs in RNA transcription, virion assembly, cell attachment and/or viral replication. In addition, structural information and transcription mechanism of AqRVs have been in‐depth studied through cryo‐electron microscopy combined with three‐dimensional image reconstruction. Although far from enough, structural and functional studies of AqRVs provide substantial insights into how viral proteins coordinate the replication of AqRVs and escape the host immune response. Grass carp reovirus (GCRV) is the most pathogenic AqRV isolated from aquatic animals. The completion of GCRV lifecycle requires the participation of host proteins. So far, many host factors involved in the entry and replication of GCRV have been identified. Based on the function of viral proteins and the viral lifecycle, many vaccines and antiviral agents have been developed to prevent the replication and infection of GCRV. This review summarises the structural characteristics and the composition of core proteins of AqRVs, as well as synergistic mechanisms of structural proteins on genome transcription and virus entry of AqRVs. In addition, the review highlights our current knowledge for the infection and replication, functions of non‐structural proteins, immune escape mechanisms, as well as the vaccines and antiviral agents of AqRVs, especially for GCRV. A better understanding of structure, function and immune evasion strategies of AqRVs will offer new targets for prevention and control of AqRVs in aquaculture.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%