Clinical features and evolution of alveolar echinococcosis in France from 1982 to 2007: Results of a survey in 387 patients

Global Distribution of Alveolar and Cystic Echinococcosis

“…High-risk areas included the Massif Central and the northeastern regions of the country, where most cases either resided in villages or towns or had farming or gardening activities (Piarroux et al, 2013). A recent study in France based on AE cases between 1982 and 2007 confirmed that the risk of AE was associated with mountain climates/landscapes (Piarroux et al, 2015).…”

“…Thus, there are approximately 1600 cases of AE per annum in Europe, Russia and central Asia resulting in 33,000 or 21 DALYs per case. Survival analyses of French and Swiss AE patients have shown that modern treatments such as resection of liver lesions followed by prolonged therapy with benzimadazoles can result in survival of AE patients similar to those of healthy populations Piarroux et al, 2011). Where treatment options are available, the burden in terms of DALYs is modest because of the improved prognosis; for example, in Switzerland, there is a total burden of approximately 78 DALYs per annum due to AE, or 3.7 DALYs per case, 10 times less than the global estimate .…”

“…Survival analysis on databases of French and Swiss AE patients has shown that advances in diagnosis, staging and state of the art treatments [chapter: EchinococcuseHost Interactions at Cellular and Molecular Levels by Brehm and Koziol (2017)] can result in survival of AE patients nearly comparable to the unaffected general population Piarroux et al, 2011 (Wahlstrom et al, 2015). Main definitive hosts for E. multilocularis in DK and SE are red foxes (possibly raccoon dogs in Jutland, DK).…”

Multimodality imaging in diagnosis and management of alveolar echinococcosis: an update

“…Other abdominal organs are affected by direct invasion or metastatic dissemination of the primary lesions. Invasions of the diaphragm, perirenal region, abdominal lymph nodes, peritoneum, mesenteric tissues, spleen, pancreas, adrenal glands, kidneys, gallbladder, retroperitoneum, abdominal wall, and the stomach have been reported (3,15,(22)(23)(24). The spleen is the most commonly invaded intra-abdominal organ by metastasis.…”

“…The spleen is the most commonly invaded intra-abdominal organ by metastasis. Rarely, it can be directly invaded by liver lesions (22). Lesion characteristics similar to the liver are seen on splenic invasion imaging (15,25).…”