Clinical features and hearing prognosis of idiopathic sudden sensorineural hearing loss in patients undergoing hemodialysis: A retrospective study

Yamamoto, Kengo; Kurioka, Takaomi; Furuki, Shogo; Sano, Hajime; Ohashi, Kentaro; Ohki, Motofumi; Yamashita, Taku

doi:10.1002/lio2.630

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…However, in their cases, the initial hearing threshold was relatively lower and the age group was considerably younger compared to those in other studies, which likely contributed to their favorable outcomes. In a similar study conducted by Yamamoto et al 20 , no statistically significant differences were observed in the pretreatment hearing level and recovery of the affected ear between the HD and non-HD groups ( P = 0.12). However, a limitation of this study was the inclusion of a higher number of patients with diabetes compared to those included in the control group, which could have potentially acted as a confounding variable 21 .…”

Section: Discussionmentioning

confidence: 51%

Treatment outcomes for idiopathic sudden sensorineural hearing loss in dialysis patients

Kim,

Lee,

Kim

et al. 2024

Sci Rep

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Idiopathic sudden sensorineural hearing loss (ISSNHL) is challenging for both nephrologists and otolaryngologists treating patients undergoing dialysis. This single-center, retrospective, observational study investigated the treatment outcomes of patients with ISSNHL undergoing dialysis, enrolling 700 patients (47 undergoing and 653 not undergoing dialysis) diagnosed with ISSNHL between January 2005 and December 2021 at Asan Medical Center, Republic of Korea. To balance pre-existing clinical characteristics, 1:5 propensity score matching (PSM) was performed with the patients who were not undergoing dialysis. Treatment included high-dose systemic steroid therapy or intra-tympanic steroid injections. The pure tone average of the groups was compared before and 2 weeks and 2 months after treatment. The hearing-improvement degree was evaluated using Siegel's criteria. Before PSM, age, prevalence of diabetes or hypertension, initial hearing threshold at each frequency level (0.5, 1, 2, and 4 kHz), and treatment strategies exhibited significant between-group differences. However, in the PS-matched cohort, none of the confounders showed significant between-group differences. Two months after steroid treatment, the non-dialysis patient group demonstrated significantly higher average improvement in pure tone audiometry (P = 0.029) and greater percentage of complete response according to Siegel's criteria. This study suggests that treatment outcomes for ISSNHL are significantly poorer for patients undergoing than for those not undergoing dialysis.

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Section: Discussionmentioning

confidence: 51%

Treatment outcomes for idiopathic sudden sensorineural hearing loss in dialysis patients

Kim,

Lee,

Kim

et al. 2024

Sci Rep

View full text Add to dashboard Cite

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“…However, it should be noted that in their cases, the initial hearing threshold was relatively lower and the age group was considerably younger compared to that in other studies, which likely contributed to their favorable outcomes. In a similar study conducted by Yamamoto et al [17] , no statistically signi cant differences were observed in the pre-treatment hearing level and recovery of the affected ear between the HD and non-HD groups (P = 0.12). However, it is important to note that a limitation of this study was the inclusion of a higher number of patients with diabetes compared to the control group, which could have potentially acted as a confounding variable [18] .…”

Section: Discussionmentioning

confidence: 51%

Treatment outcomes for idiopathic sudden sensorineural hearing loss in dialysis patients

Kim

Lee

Kim

et al. 2023

Preprint

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Idiopathic sudden sensorineural hearing loss (ISSNHL) poses a significant challenge for nephrologists in the treatment of dialysis patients. Due to limited studies comparing the treatment response between dialysis and non-dialysis patients, physicians face difficulties in managing this patient population. Therefore, this study aimed to investigate the treatment outcomes of dialysis patients with ISSNHL. This single-center, retrospective, observational study enrolled 700 patients diagnosed with ISSNHL between January 2005 and December 2021 at Asan Medical Center, Korea. Among them, 47 were dialysis patients, while 653 were non-dialysis patients. To balance pre-existing clinical characteristics, a 1:5 propensity score matching analysis was performed on the non-dialysis patients. The standard protocol involved administering high-dose systemic steroid therapy or intra-tympanic steroid injections. The pure tone average of the two groups was compared before initiating treatment, after 2 weeks, and after 2 months of treatment. The degree of improvement in the hearing was evaluated using Siegel's criteria. Before propensity score matching, the age, prevalence of diabetes or hypertension, initial hearing threshold at each frequency level (0.5, 1, 2, and 4 kHz), and treatment strategies exhibited statistically significant differences between the two groups. However, in the propensity score-matched cohort, none of the measured confounding variables showed statistically significant differences between the groups. Two months after steroid treatment, the non-dialysis patient group demonstrated a significantly higher average improvement in pure tone audiometry (P = 0.017) and a greater percentage of complete response according to Siegel's criteria compared to the dialysis patient group (26.8% vs. 6.4%). This study suggests that dialysis patients exhibit significantly poorer treatment outcomes for ISSNHL compared to non-dialysis patients.

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“…22 The results of this study were similar to those of Vilayur's study, as cited by Yamamoto et al, who found that the prevalence of CKD in those aged 50-59 years was 4.2% and increased to 52.2% at the age of 80-99 years. 24 In this study, the age was limited to 60 years to avoid prebiacusis bias, so we could not observe the prevalence at those over 60 years of age. Gabr et al's study found no statistically significant difference between groups of normal people, CKD patients with or without hemodialysis based on sex and age with p>0.01.…”

Section: Articlementioning

confidence: 99%

Correlation between Blood Urea Nitrogen Level and Cochlear Outer Hair Cell Function in Non-Dialysis Chronic Kidney Disease Patients

Purnami¹,

Roosmilasari²,

Artono³

et al. 2022

Journal of Public Health Research

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Background: Hearing loss due to impaired cochlear function, which results from increased blood urea nitrogen (BUN) level, is one of the important clinical problems in chronic kidney disease (CKD) patients with uremia. This study aims to determine correlation between blood urea nitrogen (BUN) levels and cochlear Outer Hair Cell (OHC) dysfunction in non-dialysis stage 3-5 CKD patients so that the BUN levels may also be used to determine the presence of cochlear OHC dysfunction. Design and methods: An observational analytic study with a cross sectional design and consecutive sampling. This study was conducted from November 2019 to February 2020 at the Department of Internal Medicine, Soetomo Hospital, Surabaya, Indonesia, and Otorhinolaryngology-Head and Neck Surgery Department, Soetomo Hospital, Surabaya, Indonesia. Non-dialysis CKD patients who met the inclusion and exclusion criteria were subjected to a Distortion Product Otoacoustic Emissions (DPOAE) test to assess cochlear OHC function at the Otorhinolaryngology-Head and Neck Surgery, Soetomo Hospital, Surabaya. Results: Female patients were in larger number than male patients in a ratio of 1 : 2. Most of the patients were between 51-60 years of age. DPOAE distribution was referred in 25 patients (83.3%) and pass in 5 patients (16.7%). The highest pass was at 2000 Hz in 24 patients (80.0%), while the refer results were mostly at 12,000 Hz in 29 patients (96.7%). The highest average signal to noise ratio (SNR) was at 2000 Hz and 4000 Hz (12.77 dB and 11.13 dB), while the lowest at 11,000 Hz and 12,000 Hz (1.60 dB and 1.03 dB). Pearson's correlation test on DPOAE results did not show a significant correlation (P >0.05) between BUN levels and impaired cochlear OHC function.Conclusions: There was no correlation between increased blood urea nitrogen levels and cochlear outer hair cell function disorders in non-dialysis patients with CKD stage 3-5.

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Clinical features and hearing prognosis of idiopathic sudden sensorineural hearing loss in patients undergoing hemodialysis: A retrospective study

Cited by 3 publications

References 12 publications

Treatment outcomes for idiopathic sudden sensorineural hearing loss in dialysis patients

Treatment outcomes for idiopathic sudden sensorineural hearing loss in dialysis patients

Treatment outcomes for idiopathic sudden sensorineural hearing loss in dialysis patients

Correlation between Blood Urea Nitrogen Level and Cochlear Outer Hair Cell Function in Non-Dialysis Chronic Kidney Disease Patients

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