Clinical features and laboratory characteristics of patients hospitalized with COVID-19: single centre report from Egypt

Kassas, Mohamed El; Asem, Noha; Abdelazeem, Amr; Madkour, Ahmad E.; Sayed, Hamdy; Tawheed, Ahmed; Shafie, Ahmed; Gamal, Mahmoud; Elsayed, Hassan; Badr, Mohamed; Hassany, Mohamed; Omran, Dalia; Fouly, Amr El

doi:10.3855/jidc.13156

Cited by 17 publications

(19 citation statements)

References 35 publications

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“…In our study population, there were 34 COVID-19 pregnant ladies (3.4%) which is much higher compared to a national reported rate of (0.286%) for females in the reproductive age[ 38 , 41 ]. This marked discrepancy can be explained by the societal concern over pregnancy with concerns over the mother and child and immediate request for medical advice.…”

Section: Discussionmentioning

confidence: 65%

Maternal COVID-19 and neonatal hearing loss: a multicentric survey

Mostafa

Mostafa²,

Fiky

et al. 2021

Eur Arch Otorhinolaryngol

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Purpose Gestational SARS-Cov-2 infection can impact maternal and neonatal health. The virus has also been reported of causing sensorineural hearing loss. The objective of this study was to determine the possible effect of maternal SARS-COV-2 infection on neonatal hearing as identified during universal hearing screening. Methods Retrospective cohort study in two tertiary referral centers including all neonates born from November 2020 through April 1st, 2021 and undergoing the universal hearing screening program. Maternal Covid-19 infection was recorded (timing and severity) and the results of hearing screening of their neonates compared to the incidence of neonatal hearing loss results of the national universal screening program during the same period. Results A total of 984 neonates were included (508 males and 476 females). Sixty-three neonates were excluded due to comorbidities which could cause hearing loss. The incidence of failed responses in the community at large was 2.3%. Twenty-seven failed both steps of screening (2.9%; p < 0.2). There were 34 Covid-19 positive mothers (17 in the first trimester, 8 in the second and 9 in the third). Twenty-nine neonates failed the first screening ( p < 0.00001) but on further testing only one neonate failed (2.9%). Conclusion In this study, neonates born to Covid-19 positive mothers do not seem to have an increased risk of hearing loss. However longer follow-up of these neonates is mandatory to detect any possible delayed effects of the virus.

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Section: Discussionmentioning

confidence: 65%

Maternal COVID-19 and neonatal hearing loss: a multicentric survey

Mostafa

Mostafa²,

Fiky

et al. 2021

Eur Arch Otorhinolaryngol

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“…Studies from India have shown that up to 14% of symptomatic patients developed a severe illness and the in-hospital mortality ranged was 4.5 to 5% with similar risk factors as those reported from Bangladesh [5,6]. A Singlecenter study from Egypt reported a greater incidence of hospitalization and severity in patients with an age of greater than 50 years [7]. Limited data have been reported from small studies in Pakistan largely confined to intensive care settings [8,9].…”

Section: Introductionmentioning

confidence: 92%

Clinical characteristics and outcomes of COVID-19: Experience at a major tertiary care center in Pakistan

Nasir

Habib

Khanum

et al. 2021

J Infect Dev Ctries

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Introduction: Limited data exist on clinical characteristics and outcomes of hospitalized COVID-19 patients in low-middle income countries. We aimed to describe the clinical spectrum and outcomes of hospitalized COVID-19 patients at a tertiary-care center in Karachi, Pakistan. Methodology: We conducted an observational study of adult COVID-19 patients hospitalized between February-June 2020. Patients with a discharge diagnosis of COVID-19 and PCR positivity were included. We created logistic regression models to understand association of clinical characteristics with illness severity and in-hospital mortality. Results: The study population comprised 445 patients [67% males, median age 53 (IQR 40-64) years]. Majority of patients (N = 268; 60%) had ≥ 1 co-morbid [37.5% hypertension, 36.4% diabetes]. In-hospital mortality was 13%. Age ≥ 60 (aOR] =1.92; 95 %CI = 1.23-3.03), shortness of breath (aOR=4.43; 95% CI=2.73-7.22), CRP ≥150mg/L (aOR:1.77; 95% CI=1.09-2.85), LDH ≥ 500 I.U/L (aOR:1.98; 95% CI=1.25-3.16), Neutrophil-to-Lymphocyte ratio (NLR) ≥5 (aOR:2.80; 95%CI = 1.77-4.42) and increase in serum creatinine (aOR:1.32; 95%CI=1.07-1.61) were independently associated with disease severity. Septic shock (aOR: 13.27; 95% CI=3.78-46.65), age ≥ 60 (aOR: 3.26; 95% CI=1.07-9.89), Ferritin ≥ 1500ng/ml (aOR: 3.78; 95% CI=1.21-11.8), NLR ≥ 5 (aOR: 4.04; 95% CI=1.14-14.35) and acute kidney injury (aOR: 5.52; 95% CI=1.78-17.06) were independent predictors of in-hospital mortality. Conclusions: We found multiple predictors to be independently associated with in-hospital mortality, except diabetes and gender. Compared to reports from other countries, the in-hospital mortality among COVID-19 patients was lower, despite a high burden of co-morbidities. Further research is required to explore reasons behind this dichotomy.

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“…Moreover, variations were also noted between the second and third waves [14] , [15] . Despite the changes in patients’ demographic, clinical, and laboratory characteristics with COVID-19 during the different pandemic waves, only a few studies have observed these characteristics in Egypt during the first pandemic wave [4] , [16] . Furthermore, no previous studies were retrospectively conducted on patients with COVID-19 to determine these characteristics in Egypt during the second and third waves.…”

Section: Introductionmentioning

confidence: 99%

Demographic, clinical, and laboratory characteristics of patients with COVID-19 during the second and third waves of the pandemic in Egypt

Eid¹,

Attia²,

Hassan³

et al. 2021

Journal of Infection and Public Health

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Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus that belongs to the coronaviruses and causes coronavirus disease 2019 (COVID-19). In this study, we explored the demographic details, clinical features, and routinely conducted laboratory investigations of patients with COVID-19 during the second and third waves of the pandemic to understand their possible diagnostic and prognostic values in Egypt. Methods In this retrospective cohort study, the demographic characteristics, detailed medical history, laboratory findings, and symptoms of all enrolled patients with SARS-CoV-2 were collected from the medical records of Beni Suef University Hospitals between December 15, 2020, and April 15, 2021. Results This retrospective study included 473 patients, almost all of whom were elderly. The median age of the patients was 48 years, and those with moderate and severe disease were older than those with mild infections. The proportion of females was higher (63.4%) than males (36.6%). Diabetes mellitus (DM) was the most common comorbidity (17.3%), and fever was the most typical manifestation of COVID-19 (62.6%). Those with severe disease showed a higher C-reactive protein level (CRP) than those with moderate (p-value 0.009) or mild (p-value 0.01) diseases. Serum ferritin levels were significantly higher in patients with severe disease than in those with moderate disease (p-value 0.018). In contrast, D-dimer and serum creatinine were normal and showed no significant difference in all comparisons (p-value overall 0.21). Conclusion This study observed several variations in COVID-19 patients’ characteristics. The new manifestations included skin rash, bone and low back pains, and rigors. In contrast to females, most males had moderate-to-severe illness. Old age and higher body mass index was associated with increasing severity. D-dimer and complete blood count were normal and could not identify potential COVID‐19 patients. Patients who had mild illness were still at risk of developing post-COVID complications.

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Clinical features and laboratory characteristics of patients hospitalized with COVID-19: single centre report from Egypt

Cited by 17 publications

References 35 publications

Maternal COVID-19 and neonatal hearing loss: a multicentric survey

Maternal COVID-19 and neonatal hearing loss: a multicentric survey

Clinical characteristics and outcomes of COVID-19: Experience at a major tertiary care center in Pakistan

Demographic, clinical, and laboratory characteristics of patients with COVID-19 during the second and third waves of the pandemic in Egypt

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