Clinical features and management of autoimmune hepatitis

Krawitt, Edward L.

doi:10.3748/wjg.14.3301

Cited by 47 publications

(38 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Type 2 AIH is characterized by presence of anti liver kidney microsomal (LKM) and/or antiliver cytosol (LC1) antibodies. 8 Type 2 AIH is less common and tends to be more severe than AIH type 1. It shares most of the features with AIH-1, but occurs more commonly in children.…”

mentioning

confidence: 99%

HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population

Kaur

Minz

Anand

et al. 2014

Journal of Clinical and Experimental Hepatology

View full text Add to dashboard Cite

Background: Autoimmune hepatitis is a polygenic disorder of unknown etiology, where genetic factors affect the occurrence and clinical phenotype of the disease. It has been reported as a rare disease entity in the Indian subcontinent. This study was undertaken to investigate the association of HLA alleles with autoimmune hepatitis type 1 and type 2 in north Indian population and to analyze if distinct human leukocyte antigen (HLA) alleles help in characterization of the subtypes of autoimmune hepatitis. Methods: Sixty-eight patients with autoimmune hepatitis and 128 healthy controls were recruited in the study. Out of 68 patients, 55 were diagnosed with autoimmune hepatitis type 1 and 13 with autoimmune hepatitis type 2. The patients and the controls were typed for HLA class II alleles by PCR-SSP method. Results: HLA DRB1*04 and DRB1*08 were found to be significantly associated with autoimmune hepatitis type 1 in north Indian population. It was also observed that DRB1*04, DRB1*13 were significantly associated with pediatric autoimmune hepatitis type 1 and DRB1*08 was significantly associated with adult autoimmune hepatitis type 1. DRB1*14 was significantly associated with autoimmune hepatitis type 2. Conclusion: The study indicates that autoimmune hepatitis in north Indian population is associated with HLA alleles that may help to discriminate the subtypes as autoimmune hepatitis type 1 and type 2. The study also highlights the ethnic variations in the Indian subcontinent in context to the genetic association of HLA with autoimmune diseases. ( J CLIN EXP HEPATOL 2014;4:14-18)

show abstract

mentioning

confidence: 99%

HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population

Kaur

Minz

Anand

et al. 2014

Journal of Clinical and Experimental Hepatology

View full text Add to dashboard Cite

show abstract

“…Seronegative AIH has typical appearance of AIH on histology, responds to immunosuppression, but lacks detectable autoantibodies . [18] This is a rare form of AIH in adults, but its prevalence and clinical characteristics remain to be defined in children.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Liver Biopsy: A clinicopathologic study

Sathe

Mahale

2017

APALM

View full text Add to dashboard Cite

Extrahepatic Biliary Atresia: (Fig 1 a, b) -A total of 26 cases of EHBA were found in our study. Among these, 25 were infants. The commonest symptom was icterus followed by clay colored stools. Liver function test results were available in 17 cases. Liver enzymes were elevated in the following range -SGOT (131-405 U/L), SGPT (51-Pragati Aditya Sathe* and Dipali Eknath Mahale Department of Pathology, Seth GS Medical College& KEM Hospital, Mumbai, India ABSTRACT Introduction:The spectrum of liver diseases in children differs from that in adults. Different diagnostic modalities which are available are not capable of diagnosing the liver disease individually unless they are supplemented by a liver biopsy. Hence liver biopsy is an invaluable tool in the diagnosis of liver diseases. Aims and Objectives:The aims of this study were to study the spectrum of liver diseases in pediatric age group at our institute, to correlate the liver biopsy findings with clinical findings and laboratory investigations and to review the literature on this topic. Results:We received a total of 130 liver biopsies during the five year study. Out of these, 65 biopsies were performed in children below one year of age while the remaining 65 liver biopsies belonged to children aged more than one year. The common indications for performing liver biopsies included prolonged jaundice, clay colored stools, abdominal distension, abdominal pain, suspected inborn error of metabolism and for a suspected hepatic tumor. Extrahepatic biliary atresia was the commonest pathology found in children below one year of age whereas metabolic disease was the most common pathology found in children above one year of age. Special stains helped in refining the diagnosis further. Laboratory investigations were correlated to offer a complete diagnosis. Conclusion:Paediatric liver biopsy is of value in diagnosis of disorders where clinical and laboratory parameters overlap. At the same time, clinical and laboratory correlation is a must due to overlapping histologic features of many liver diseases.

show abstract

“…It is possible that the herbal medicine may have caused bile duct toxicity, autoimmune hepatitis and resulted in transformation to malignant cells. However, it appears more plausible that the herbal remedy simply resulted in drug-induced hepatitis with histological findings that mimic autoimmune hepatitis [17] . The case also reinforces the suspicion that the association of autoimmune hepatitis with CCA may be more than mere coincidence.…”

Section: Discussionmentioning

confidence: 99%

Use of endoscopic ultrasound for diagnosis of cholangiocarcinoma in auto-immune hepatitis

Rial

Henderson²,

Bhattacharyya³

et al. 2010

WJGE

View full text Add to dashboard Cite

In this report, a patient was exposed to an herbal re medy for hypercholesterolemia. She became acutely jaundiced while taking the remedy and presented for medical care. Endoscopic ultrasound was utilized, and found a distal common bile duct mass. Endosco pic retrograde cholangiopancreatography guided bile duct biopsies revealed that the mass was cholangio carcinoma (CCA). This case highlights a unique associa tion between autoimmune hepatitis and CCA. It also highlights that EUS can be safely used in patients with cirrhosis to spare invasive evaluation such as explora tory laporotomy for diagnosis and staging of cholangio carcinoma.© 2010 Baishideng. All rights reserved.

show abstract

Clinical features and management of autoimmune hepatitis

Cited by 47 publications

References 38 publications

HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population

HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population

Pediatric Liver Biopsy: A clinicopathologic study

Use of endoscopic ultrasound for diagnosis of cholangiocarcinoma in auto-immune hepatitis

Contact Info

Product

Resources

About