2014
DOI: 10.3324/haematol.2014.112151
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Clinical features and outcome of SIL/TAL1-positive T-cell acute lymphoblastic leukemia in children and adolescents: a 10-year experience of the AIEOP group

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Cited by 41 publications
(32 citation statements)
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“…and D'Angio et al., STIL‐TAL1 was reported to be more common in males than in females, which theoretically would increase the likelihood of positive cases in our material . Similarly, high levels of white blood cells (WBCs) at diagnosis in patients positive for STIL‐TAL1 have been reported by several studies . In our material, a total of eighteen patients had WBC > 100 × 10 9 /l, which further indicates this to be a suitable patient group for STIL‐TAL1 analysis.…”
Section: Discussionsupporting
confidence: 74%
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“…and D'Angio et al., STIL‐TAL1 was reported to be more common in males than in females, which theoretically would increase the likelihood of positive cases in our material . Similarly, high levels of white blood cells (WBCs) at diagnosis in patients positive for STIL‐TAL1 have been reported by several studies . In our material, a total of eighteen patients had WBC > 100 × 10 9 /l, which further indicates this to be a suitable patient group for STIL‐TAL1 analysis.…”
Section: Discussionsupporting
confidence: 74%
“…However, in studies by Mansur et al. and D'Angio et al., STIL‐TAL1 was reported to be more common in males than in females, which theoretically would increase the likelihood of positive cases in our material . Similarly, high levels of white blood cells (WBCs) at diagnosis in patients positive for STIL‐TAL1 have been reported by several studies .…”
Section: Discussionmentioning
confidence: 49%
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“…Patients with an elevated WBC count ($100 3 10 9 /L) are more likely to have certain genetic aberrations, such as SIL-TAL1 fusions, [45][46][47] and have a different response to treatment, with more frequent poor PR and slower MRD clearance, although the prognostic value of the WBC count often loses independent discrimination on multivariate analysis with MRD. 5,7,35,47 This was not the case here, when a WBC count $200 3 10 9 /L at diagnosis proved to be an independent, albeit weaker, risk factor, in addition to MRD and the oncogenetic classifier.…”
mentioning
confidence: 99%
“…Patients exhibiting the E2A-PBX1 gene fusion, presented late relapses, after more than 3 years after the diagnosis. Different studies showed controversial results with respect to the prognosis of the patients SIL-TAL rearrangements (30)(31)(32). In the present study, early relapses after diagnosis were registered for the patients having SIL-TAL rearrangements: one patient presented relapse in less than one year from the diagnosis, the other two patients relapsed between one year and two years after the moment of diagnosis.…”
Section: Discussionmentioning
confidence: 77%