Clinical Features and Outcomes of Patients With Human Immunodeficiency Virus With COVID-19

Gervasoni, Cristina; Meraviglia, Paola; Riva, Agostino; Giacomelli, Andrea; Oreni, Letizia; Minisci, Davide; Atzori, Chiara; Ridolfo, Annalisa; Cattaneo, Dario

doi:10.1093/cid/ciaa579

Cited by 241 publications

(337 citation statements)

References 19 publications

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“…Regarding Casado et al [24] , the mean age is slightly lower in our cohort, with lower rates of comorbidities; also less patients had a history of severe immunodeficiency (<200 CD4) and time before infection by HIV was shorter (10.8 years vs. 19.5). Our data are even more similar to those described by Gervasoni et al [25] . Härter's cohort [26] has a similar mean age but showed higher severity, hospitalization, admission to ICU and mortality rates.…”

Section: Discussionsupporting

confidence: 93%

“…In spite of a similar severe disease rate (28,6% vs. 25%), both hospital admission rate (32.3% vs. 55%) and patients who required ICU care (3.1 vs. 12%) were significantly lower than that of Casado's findings [24] ; however, a similar mortality rate was observed (3.17% vs. 4%). Our data are closer to Gervasoni et al [25] , with similar rates of hospital admission, severity, and ICU requirements.…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

COVID-19 in people living with HIV: A multicenter case-series study

Cabello¹,

Zamarro²,

Nistal³

et al. 2021

International Journal of Infectious Diseases

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

COVID-19 in people living with HIV: A multicenter case-series study

Cabello¹,

Zamarro²,

Nistal³

et al. 2021

International Journal of Infectious Diseases

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“…There are rapidly growing information on COVID-19 infection, however, the data in HIV population remains contradictory [7,8]. Previous studies observed that low CD4 + T cell counts could actually protect against severe form of COVID-19, which suggested that immune system activation may actually increase the injury caused by COVID-19 and low CD4 + T cell counts might protect HIV-positive individuals from developing the cytokine storm observed in patients with COVID-19 [9][10][11][12][13].…”

Section: Resultsmentioning

confidence: 99%

New HIV diagnoses in patients with COVID-19: two case reports and a brief literature review

Zhang¹,

Yu²,

Ding³

et al. 2020

BMC Infect Dis

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Background COVID-19 is novel infectious disease with an evolving understanding of its epidemiology and clinical manifestations. Severe cases developed life-threatening complications, such as respiratory failure, shock, and multiple organs dysfunction. Immunocompromised patients often present atypical presentations of viral infected diseases. Case presentation We report newly diagnosed HIV infections in two patients with COVID-19 in China. In our two cases, both patients with elevated IL-6 received Tocilizumab treatment, but did not present obvious therapeutic effect. Conclusions These cases highlight possible co-detection of known immunocompromised diseases such as HIV. The two cases we reported stressed the risk of misdiagnosis, especially during the pandemic of an infectious disease and the importance of extended testing even if in immune-compromised condition the immune state may be ignored.

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“…Overall, we managed few cases of HIV/SARS-CoV-2 coinfections. Most of them were admitted with a moderate COVID-19 disease and had optimal outcomes, despite a higher average age and a higher proportion of patients with comorbidities (75%) in comparison with other cohorts (17,18).…”

Section: Discussionmentioning

confidence: 96%

Consequences of the COVID-19 pandemic on the continuum of the care in a cohort of people living with HIV followed in a single center of Northern Italy

Quirós-Roldán¹,

Magro²,

Carriero³

et al. 2020

Preprint

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Introduction: During the COVID-19 pandemic, hospitals faced increasing pressure, where people living with HIV risked to either acquire SARS-CoV-2 and to interrupt the HIV continuum of care.Methods: this is a retrospective, observational study. We compared the numbers of medical visits performed, antiretroviral drugs dispensed and the number of new HIV diagnosis and of hospitalizations in a cohort of people living with HIV (PLWH) followed by the Spedali Civili of Brescia between the bimester of the COVID-19 pandemic peak and the bimester of October-November 2019. Data were retrieved from administrative files and from paper and electronic clinical charts. Categorical variables were described using frequencies and percentages, while continuous variables were described using mean, median, and interquartile range (IQR) values. Means for continuous variables were compared using Student’s t-tests and the Mann-Whitney test. Proportions for categorical variables were compared using the χ2 test.Results: As of December 31st, 2019, a total of 3875 PLWH were followed in our clinic. Mean age was 51,4 ±13 years old, where 28% were females and 18.8% non-Italian. Overall, 98.9% were on ART (n=3834), 93% were viro-suppressed. A total of 1217 and 1162 patients had their visit scheduled at our out-patient HIV clinic during the two bimesters of 2019 and 2020, respectively. Comparing the two periods, we observed a raise of missed visits from 5% to 8% (p<0.01), a reduction in the number of new HIV diagnosis from 6.4 in 2019 to 2.5 per month in 2020 (p=0.01), a drop in ART dispensation and an increase of hospitalized HIV patients due to COVID-19. ART regimens including protease inhibitors (PIs) had a smaller average drop than ART not including PIs (16,6% vs 21,6%, p<0.05). Whether this may be due to the perception of a possible efficacy of PIs on COVID19 is not known. Conclusions: Our experience highlights the importance of a resilient healthcare system and the need to implement new strategies in order to guarantee the continuum of HIV care even in the context of emergency.

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Clinical Features and Outcomes of Patients With Human Immunodeficiency Virus With COVID-19

Abstract: Little is known about the clinical outcomes of HIV patients infected with SARS-CoV-2. We describe 47 patients referred to our hospital between 21 February and 16 April 2020 with proven/probable COVID-19, 45 (96%) of whom fully recovered and two died.

Cited by 241 publications

References 19 publications

COVID-19 in people living with HIV: A multicenter case-series study

COVID-19 in people living with HIV: A multicenter case-series study

New HIV diagnoses in patients with COVID-19: two case reports and a brief literature review

Consequences of the COVID-19 pandemic on the continuum of the care in a cohort of people living with HIV followed in a single center of Northern Italy

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