Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis

Gao, Yijie; Ye, Lei; Zhang, Jia-shuo; Yin, Yangxue; Liu, Min; Yu, Hongbiao; Zhou, Rong

doi:10.22541/au.158739987.76562417

Cited by 22 publications

(53 citation statements)

References 28 publications

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“…After the application of the eligibility criteria, 39 studies were finally included [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ], one (2.6%) of which was described as “rapid” [ 42 ] and two (5.1%) as “scoping” systematic reviews [ 30 , 50 ]. Thirteen (33%) of them also undertook a meta-analysis [ 14 , 16 , 18 , 19 , 24 , 25 , 27 , 36 , 38 , 40 , 48 ,…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen (33%) of them also undertook a meta-analysis [ 14 , 16 , 18 , 19 , 24 , 25 , 27 , 36 , 38 , 40 , 48 , 49 , 52 ]. Twenty-nine (74%) reviews evaluated quality of individual studies [ 14 , 15 , 16 , 19 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 37 , 41 , 42 , 43 , 44 , 46 , 47 , 48 , 51 , 52 ], with one of them doing so, in a subjective manner, without utilizing any assessment tool [ 42 ]. Among the eligible systematic reviews’ last search dates, the most recent one took place on 8 July 2020.…”

Section: Resultsmentioning

confidence: 99%

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Maternal and Neonatal Characteristics and Outcomes of COVID-19 in Pregnancy: An Overview of Systematic Reviews

Papapanou

Papaioannou

Petta

et al. 2021

IJERPH

131

109

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(1) Background: A considerable number of systematic reviews, with substantial heterogeneity regarding their methods and included populations, on the impact of COVID-19 on infected pregnant women and their neonates, has emerged. The aim was to describe the obstetric-perinatal and neonatal outcome of infected pregnant women and their newborns during the COVID-19 pandemic; (2) Methods: Three bibliographical databases were searched (last search: 10 September 2020). Quality assessment was performed using the AMSTAR-2 tool. Primary outcomes included mode of delivery, preterm delivery/labor, premature rupture of membranes (PROM/pPROM) and abortions/miscarriages. Outcomes were mainly presented as ranges. A separate analysis, including only moderate and high-quality systematic reviews, was also conducted. The protocol was registered with PROSPERO (CRD42020214447); (3) Results: Thirty-nine reviews were analyzed. Reported rates, regarding both preterm and term gestations, varied between 52.3 and 95.8% for cesarean sections; 4.2–44.7% for vaginal deliveries; 14.3–63.8% specifically for preterm deliveries and 22.7–32.2% for preterm labor; 5.3–12.7% for PROM and 6.4–16.1% for pPROM. Maternal anxiety for potential fetal infection contributed to abortion decisions, while SARS-CoV-2-related miscarriages could not be excluded. Maternal ICU admission and mechanical ventilation rates were 3–28.5% and 1.4–12%, respectively. Maternal mortality rate was <2%, while stillbirth, neonatal ICU admission and mortality rates were <2.5%, 3.1–76.9% and <3%, respectively. Neonatal PCR positivity rates ranged between 1.6% and 10%. After accounting for quality of studies, ranges of our primary outcomes remained almost unchanged, while among our secondary outcomes, maternal ICU admission (3–10%) and mechanical ventilation rates (1.4–5.5%) were found to be relatively lower; (4) Conclusions: Increased rates of cesarean sections and preterm birth rates were found, with iatrogenic reasons potentially involved. In cases of symptomatic women with confirmed infection, high maternal and neonatal ICU admission rates should raise some concerns. The probability of vertical transmission cannot be excluded. Further original studies on women from all trimesters are warranted.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Maternal and Neonatal Characteristics and Outcomes of COVID-19 in Pregnancy: An Overview of Systematic Reviews

Papapanou

Papaioannou

Petta

et al. 2021

IJERPH

131

109

View full text Add to dashboard Cite

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“…This may be due to changes in the immune system in pregnant women. Currently, there is no evidence that pregnancy alleviates symptoms of the disease and more studies are needed to confirm this [13]. This result is similar to a new meta-analysis published in early September 2020: Pregnant women infected with SARS-CoV-2 have less symptoms of fever (OR 0.43, 95% CI 0.22-0.85) and myalgia (OR 0.48, 95% CI 0.45-0.51) compared with non-pregnant women infected with SARS-CoV-2 [6].…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, as of early September 2020, there have been 07 meta-analyzes and systematic reviews of pregnancy outcomes in SARS-CoV-2 infected pregnant women published in English. Results of 06 meta-analyzes and systematic reviews all showed that the rate of preterm birth and cesarean section in pregnant women infected with SARS-CoV-2 was higher than in women without SARS-CoV-2 [6,7,13,14,18,19], meanwhile, 01 meta-analysis by Melo, et al had the opposite result, that COVID-19 infection in pregnant women might not associated with preterm birth [9]. However, the authors of these meta-analyzes and systematic reviews all argue that cautions should be taken when interpreting the results due to limitations (i.e most of studies were retrospective studies and case reports; and lack of high quality evidence).…”

Section: Disclosure Statementmentioning

confidence: 99%

SARS-CoV-2 Infection in Pregnancy: A Case Report on the First Emergency Cesarean Section in Vietnam and Literature Review

Dinh¹,

Van²,

Pham³

2020

Obstet Gynecol Cases Rev

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On March 11, the World Health Organization officially declared an outbreak of acute respiratory infections (COVID-19) caused by a new strain of the Corona virus (SARS-CoV-2) as a pandemic [1]. Vietnam reported the first case of SARS-CoV-2 infection on January 22, 2020 being a Chinese coming from Wuhan-where earliest case in the world was detected [2]. As of September 4, 2020, there were 26, 455, 964 cases recorded in the world and in Vietnam the number of infected people is 1046 [3]. Although the number of SARS-CoV-2 infections is increasing globally, evidence of the spread, incidence, and impact of SARS-CoV-2 infection on both mother and child remains limited [4]. Due to physiological changes in the immune system and cardiovascular-respiratory system, pregnant women are considered to be at high risk of viral respiratory infections. Based on data from previous outbreaks of severe acute respiratory syndrome Coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), it has been found that pregnant women are more susceptible to adverse outcomes such as the need of intubation, intensive care, renal failure and death [5]. A meta-analysis by Allotey J, et al., including 77 studies (13,118 women infected with SARS-CoV-2 and 83,486 women of non-pregnant age of childbearing Case RePoRT anD LiTeRaTuRe ReView

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“…Sehingga apabila ada gangguan kesehatan pada ibu hamil, ia akan langsung dibawa ke fasilitas kesehatan untuk segera diperiksa sehingga dan hal ini berimplikasi pada penurunan keterlambatan dalam tatalaksana. Penanganan awal ini juga menurunkan risiko gejala klinis ibu hamil untuk berkembang menjadi berat (Gao et al, 2020;Zeng et al, 2020;Qiancheng et al, 2020) Selanjutnya penelitian yang dilakukan oleh Zeng et al mengungkapkan suatu fakta, nyaitu apabila dilakukan perbandingan antibodi IgG SARS-CoV-2 antara pria dan wanita, maka wanita dengan infeksi COVID-19 akan memiliki antibodi yang jauh lebih tinggi. Produksi antibodi ini sangat tinggi pada awal infeksi, dan ini yang menjelaskan mengapa wanita termasuk ibu hamil memiliki gejala klinis yang relatif lebih ringan dibandingkan dengan pria.…”

Section: Hasil Dan Pembahasanunclassified

Karakteristik gejala klinis kehamilan dengan Coronavirus disease (COVID-19)

Yuliana

2020

jiskh

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Coronavirus disease 2019 (COVID-19) merupakan penyakit infeksi respiratorik akut yang menyebar dengan cepat secara global dalam waktu yang singkat. COVID-19 disebabkan oleh novel coronavirus yang diketahui sebagai Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Virus ini berupa RNA virus dengan rantai tunggal. Transmisi virus ini menyebar sangat cepat melalui kontak antara manusia-ke-manusia (human-to-human contact) via droplet respiratorik dan saliva dari orang yang terinfeksi COVID-19. Gejala klinis COVID-19 dapat berupa simptomatik dan asimptomatik. World Health Organization (WHO) membagi gejala klinis COVID-19 yang simptomatik menjadi gejala klinis ringan, sedang, berat, dan kondisi kritis. Tulisan ini bertujuan untuk mengetahui gambaran klinis umum ibu hamil dengan infeksi COVID-19. Metode penelitian ini adalah dengan meninjau artikel review yang diterbitkan 1 tahun terakhir dengan kata kunci kehamilan, COVID-19, gejala klinis, dan coronavirus. Data menunjukkan bahwa mayoritas ibu hamil dengan COVID-19 memiliki gejala klinis yang ringan, dimana gejala utama yang muncul adalah demam, batuk, dan dispnea. Usia kehamilan tidak menentukan beratnya gejala klinis ibu hamil dan rata-rata ibu hamil dengan COVID-19 memiliki durasi rawat inap di rumah sakit yang singkat.

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Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis

Cited by 22 publications

References 28 publications

Maternal and Neonatal Characteristics and Outcomes of COVID-19 in Pregnancy: An Overview of Systematic Reviews

Maternal and Neonatal Characteristics and Outcomes of COVID-19 in Pregnancy: An Overview of Systematic Reviews

SARS-CoV-2 Infection in Pregnancy: A Case Report on the First Emergency Cesarean Section in Vietnam and Literature Review

Karakteristik gejala klinis kehamilan dengan Coronavirus disease (COVID-19)

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