Clinical Features and Practical Diagnosis of Bullous Pemphigoid

Schmidt, Enno; Torre, Rocco della; Borradori, Luca

doi:10.1016/j.iac.2012.04.002

Cited by 63 publications

(94 citation statements)

References 98 publications

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“…It features circulating autoantibodies against distinctive skin's basal membrane antigens and adjacent mucous membrane's antigens. 1-6 Its incidence increases with age, contrary to almost all of the autoimmune disorders. 1 It is uncommon for the disease to begin during childhood and even more so during infancy.…”

Section: Introductionmentioning

confidence: 99%

“…1-6 Its incidence increases with age, contrary to almost all of the autoimmune disorders. 1 It is uncommon for the disease to begin during childhood and even more so during infancy. 1,2,7,8-12 …”

Section: Introductionmentioning

confidence: 99%

“…1 It is uncommon for the disease to begin during childhood and even more so during infancy. 1,2,7,8-12 …”

Section: Introductionmentioning

confidence: 99%

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Bullous pemphigoid in a 3-month-old infant: case report and literature review of this dermatosis in childhood

Reis-Filho

Silva

Aguirre

et al. 2013

An. Bras. Dermatol.

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Bullous pemphigoid is an autoimmune subepidermal blistering dermatosis that is uncommon in childhood. We report a case of a female infant, 3 months old, which presented clinical and laboratory data for the confirmatory diagnosis of bullous pemphigoid. The authors used immunohistochemical staining for collagen type IV that allowed the differentiation of bullous pemphigoid from other subepidermal bullous diseases. Opportunely we review the clinical, immunological, therapeutic and prognostic features of this pathology in children.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bullous pemphigoid in a 3-month-old infant: case report and literature review of this dermatosis in childhood

Reis-Filho

Silva

Aguirre

et al. 2013

An. Bras. Dermatol.

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“…27 Bullous pemphigoid This is the most common autoimmune blistering dermatosis that occurs predominantly in older people. 28 It manifests as a prodromal eruption of pruritic, excoriated, eczematous, urticarial and papular lesions that evolves within weeks to months to form tense bullae, which are usually distributed on the axillae, groins, thighs, flexural sites and abdomen.…”

Section: Urticariamentioning

confidence: 99%

Pruritus in older people

2013

Rev. Clin. Gerontol.

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Pruritus in older people is caused by a wide range of dermatological, systemic, neurological and psychogenic diseases. It can also be attributed to various cutaneous drug reactions. The dermatological, neurological and immunological changes associated with ageing predispose older people to pruritus of a wide range of aetiologies. The most common cause of pruritus in older people is xerosis, or dry skin. Regular use of emollients is the mainstay of treatment for pruritus of any cause, with general measures aiming to ensure optimal skin hydration and to prevent the itch-scratch cycle. Topical treatments are generally better tolerated for localized pruritus. Anti-histamines are the predominant agents to treat pruritus, but can be inadequate in many cases. Numerous other systemic agents have been demonstrated to alleviate pruritus depending on the cause, but may be limited by their adverse effects. This article reviews the current published literature on pruritus in older people, with a practical approach to its evaluation and management in non-specialist settings.

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“…Mucosal lesions have been described in 8% to 39% of cases, and usually affect oral mucosa; the eyes, nose, larynx, pharynx, esophagus, and anogenital areas are rarely involved. 2 In the literature, the involvement of the lower respiratory tract has been suggested but not proven. There are two case reports describing patients with bullous pemphygoid who developed life-threatening hemoptysis.…”

mentioning

confidence: 99%