Clinical features and prognostic factors of breast cancer in young women: a retrospective single-center study

Wang, Weigang; Tian, Bailing; Xu, Xiaoqin; Zhang, Xiaofang; Wang, Yan; Du, Lili; Jing, Jiexian

doi:10.1007/s00404-022-06670-6

Cited by 8 publications

(8 citation statements)

References 43 publications

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“…However, the young breast cancer patients in their study had significantly better OS and comparable DFS [ 13 ]. Previous reports from India (507 patients) and China (1,968 patients) did not find significant differences in histologic types between young (≤40-year-old) and non-young breast cancer patients [ 14 , 15 ]. In a large cohort of 17,481 breast cancer patients in Sweden, ILC was found to be significantly associated with older age, ER positivity and well-differentiated tumours.…”

Section: Discussionmentioning

confidence: 89%

Young Filipino breast cancer patients have worse survival outcomes

Yap,

Marquez,

De La Serna

2023

ecancer Journal

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Background In the 2020 GLOBOCAN report, breast cancer is the 3rd most common cause of cancer-related mortality in the Philippines. The incidence of breast cancer in the young (≤40 years) was reported to be higher in the Philippines compared to other Asian countries. Several studies have consistently demonstrated poor survival outcomes in this age group due to its aggressiveness and unique tumour biology. However, data on survival outcomes of young Filipino breast cancer patients remains unknown in the Philippines. Methods A retrospective study was performed involving patients with stage I–III breast cancer who underwent definitive surgery from January 2010 to December 2015 at a single-tertiary institution. Patients were grouped according to age (≤40 and >40 years old). Their clinicopathological characteristics, treatment profile and 5-year survival outcomes were analyzed. Results A total of 524 Filipino patients (15.1% aged ≤40 years) were included. Younger patients were diagnosed at a higher stage and pathologic grade. A negative hormone receptor, high Ki67 status, and triple negative breast cancer (TNBC) subtypes were also more common among younger patients. The overall breast-conserving surgery rate was low at 8.9%. The use of adjuvant chemoradiotherapy was more common and both 5-year overall survival (OS) and disease-free survival (DFS) were lower (61.1% versus 77.1% and 31.1% versus 66.8%, respectively) in the ≤40-year-old group. In the multivariate analysis, age group, tumour size, and nodal status were significant predictors for DFS. However, only tumour size was significant for OS. Conclusion Young Filipino breast cancer patients have demonstrated unique pathologic characteristics with associated lower survival outcomes similar to the published literature. Increasing awareness of cancer screening practices among young women, provision of equitable access to healthcare, and prompt management of breast cancer in the young are crucial.

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Section: Discussionmentioning

confidence: 89%

Young Filipino breast cancer patients have worse survival outcomes

Yap,

Marquez,

De La Serna

2023

ecancer Journal

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“…Breast cancer in young women presents with higher prevalence of hormone receptor negative, triple negative and HER2+ tumors ( 29 , 40 ), elevating risk of recurrence and metastases ( 41 ). Moreover, characteristics such as larger tumor diameter (>20mm), increased proliferation/Ki-67 expression, lymphovascular invasion and lymph node involvement are common and correlate to increased mortality ( 10 , 42 – 44 ). In addition, factors relevant to young women, such as older age at first birth and not breastfeeding may contribute to increased risk of certain aggressive subtypes of YOBC, such as estrogen receptor negative (ER-) ( 45 ).…”

Section: Young Onset Breast Cancer: Clinical and Biological Aspectsmentioning

confidence: 99%

“…Current literature is limited regarding characterization, screening and treatment of YOBC, and the role of race and ethnicity. This is compounded by studies focusing on a specific demographic or being too broad as well as adopting varying definitions of YOBC and PPBC, making it difficult to compare patient outcomes ( 6 , 8 , 10 , 26 , 58 , 119 – 121 ). More diversified studies using a population under 45 with information on parity status, breast density and ethnicity would highly benefit research within this area.…”

Section: Current Detection Technologies and Barriers To Detectionmentioning

confidence: 99%

Status of breast cancer detection in young women and potential of liquid biopsy

Stibbards-Lyle,

Malinovska,

Badawy

et al. 2024

Front. Oncol.

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Young onset breast cancer (YOBC) is an increasing demographic with unique biology, limited screening, and poor outcomes. Further, women with postpartum breast cancers (PPBCs), cancers occurring up to 10 years after childbirth, have worse outcomes than other young breast cancer patients matched for tumor stage and subtype. Early-stage detection of YOBC is critical for improving outcomes. However, most young women (under 45) do not meet current age guidelines for routine mammographic screening and are thus an underserved population. Other challenges to early detection in this population include reduced performance of standard of care mammography and reduced awareness. Women often face significant barriers in accessing health care during the postpartum period and disadvantaged communities face compounding barriers due to systemic health care inequities. Blood tests and liquid biopsies targeting early detection may provide an attractive option to help address these challenges. Test development in this area includes understanding of the unique biology involved in YOBC and in particular PPBCs that tend to be more aggressive and deadly. In this review, we will present the status of breast cancer screening and detection in young women, provide a summary of some unique biological features of YOBC, and discuss the potential for blood tests and liquid biopsy platforms to address current shortcomings in timely, equitable detection.

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“…In recent years, studies have found that the age-related incidence of breast cancer is tending to be younger ( 2 , 3 ). Young breast cancer patients refer to breast cancer patients under the age of 40, and the current studies have found that young breast cancer patients have different clinical features, manifested by a higher positive rate of human epidermal growth factor receptor 2 (HER-2), a lower positive rate of estrogen receptor (ER), and a worse prognosis ( 4 - 6 ). Magnetic resonance imaging (MRI) is currently mainly used for staging assessment and preoperative evaluation in breast cancer, which has great advantages in finding small lesions, evaluating the extent of lesions, predicting the efficacy of neoadjuvant chemotherapy and evaluating prognosis ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

The comparison between young and old patients and the prognostic roles of magnetic resonance imaging-related parameter characteristics in young patients—a retrospective cohort study

Hu¹,

Jiang²,

Wang³

2023

Gland Surg

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Background: Breast dynamic enhanced magnetic resonance imaging (MRI) is an important in the diagnosis and treatment of breast cancer. However, it is unclear whether the characteristics of breast dynamic enhancement MRI-related parameters in young breast cancer patients are specific. The present study was to study the dynamic enhancement of MRI-related parameter characteristics and its correlation with clinical features in young breast cancer patients.Methods: A total of 196 breast cancer patients admitted to the People's Hospital of Zhaoyuan City from January 2017 to December 2017 were retrospectively collected, and the patients were divided into a young breast cancer group (n=56) and a control group (n=140) according to whether the patient age limit of <40 years old. All patients underwent breast dynamic enhanced MRI and were followed up for 5 years to observe whether there was recurrence or metastasis. We compared the differences of breast dynamic enhanced MRI-related parameters between the 2 groups, and then analyzed the correlation between breast dynamic enhancement MRI-related parameters and clinical features in young breast cancer patients.Results: Compared with the control group, the apparent diffusion coefficient (ADC) of the young breast cancer group was significantly reduced (0.84±0.13 vs. 0.93±0.14 ×10 −3 mm 2 /s, P<0.001); the proportion of patients with non-mass enhancement was significantly increased in the young breast cancer group (25.00% vs. 8.57%, P=0.002). The ADC was significantly positively correlated with age (r=0.226, P=0.001) and negatively correlated with the maximum diameter of the tumor (r=−0.199, P=0.005). The ADC was shown to be valuable in predicting the absence of lymph node metastasis in the young breast cancer patients, and the area under the curve (AUC) was 0.817 [95% confidence interval (CI): 0.702-0.932, P<0.001]. The ADC was shown to be valuable in predicting the absence of recurrence or metastasis in the young breast cancer patients, and the AUC was 0.784 (95% CI: 0.630-0.937, P=0.007). The rates of lymph node metastasis and recurrence at 5 years were significantly increased in young breast cancer patients with non-mass enhancement (P<0.05). Conclusions:The present study provides a reference for further evaluation of the characteristics of young breast cancer patients.

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Clinical features and prognostic factors of breast cancer in young women: a retrospective single-center study

Cited by 8 publications

References 43 publications

Young Filipino breast cancer patients have worse survival outcomes

Young Filipino breast cancer patients have worse survival outcomes

Status of breast cancer detection in young women and potential of liquid biopsy

The comparison between young and old patients and the prognostic roles of magnetic resonance imaging-related parameter characteristics in young patients—a retrospective cohort study

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