Clinical features and recurrence of Corynebacterium kroppenstedtii infection in patients with mastitis

Abstract

Background Few studies have investigated the differences in clinical features of patients with mastitis following Corynebacterium kroppenstedtii infection, and most focused on the bacterial antimicrobial susceptibility, detection methods and therapy. Methodology There were 133 patients with mastitis infected by C. kroppenstedtii between August 2016 and September 2019. C. kroppenstedtii was identified using mass spectrometry. The demographics, clinical diagnosis, laboratory test results of different types of mastitis combined with bacillus infection, and the effects of different treatments in reducing recurrence were compared. Results The incidence of pus following C. kroppenstedtii infection was higher in patients with non-granulomatous lobular mastitis (NGLM; 56.6%) than in those with granulomatous lobular mastitis (GLM; 33.3%; χ2 = 7.072, p = 0.008). While C-reactive protein (CRP) was higher in the GLM group (12.50 mg/L) than in the NGLM group (6.05 mg/L; Z = − 2.187, p = 0.029). Treatment with local lavage (triamcinolone acetonide) and antibiotics (cefuroxime) showed a recurrent rate of 25.9% in C. kroppenstedtii infection. Conclusion Increased pus, large masses, and an elevated CRP level may occur in patients with mastitis infected by C.kroppenstedtii. These clinical features may guide the determination of the bacterial infection in patients with mastitis. Combining an antibiotic with a triamcinolone acetonide lavage, preferably cefuroxime, may reduce the recurrence.

Construction of a Multi-Indicator Model for Abscess Prediction in Granulomatous Lobular Mastitis Using Inflammatory Indicators

“… 27 It has been found that GLM abscess formation is associated with N and ESR, and that high levels of N and ESR can promote GLM abscess formation. 9 , 10 , 28 ESR refers to the rate at which erythrocytes settle under certain conditions, which is related to inflammatory factors in the plasma, the number of erythrocytes, fibrin, etc. During abscess formation, an elevated ESR may indirectly reflect the intensity of inflammation in the body.…”

“…Studies have shown that there is a series of inflammatory reactions during the formation of GLM abscesses, patients may present with fever and elevated inflammatory markers such as serum white blood cell (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and neutrophil count (N). [9][10][11][12] In addition, the process of abscess formation may also present a pathophysiological state called a "cytokine storm". 11,13 For example, inflammatory cytokines such as interleukin-10 (IL-10) can induce abscess formation through the mitogen-activated protein kinase (MAPK) pathway.…”

Rare and Complicated Granulomatous Lobular Mastitis (2000–2023): A Bibliometrics Study and Visualization Analysis

“… 37 , 38 Corynebacterium kroppenstedtii is considered a challenging pathogen associated with GLM. 39 Zeng 40 reported that the recurrence rate of treatment combining steroids with antibacterial drugs was significantly lower than that of steroids alone. Commonly chosen antimicrobial agents include doxycycline, amoxicillin, ciprofloxacin, and cefuroxime.…”

Clinical characteristics and microbiota analysis of 44 patients with granulomatous mastitis

“…These two cases validate the idea that timely anti-infection treatment is effective and necessary for inhibiting Corynebacterium (Wolfrum et al, 2018 ; Yaghan et al, 2020 ). As Corynebacterium abundance decreases, the symptoms will also resolve (Johnstone et al, 2017 ; Zeng et al, 2022 ).…”

“…This study was supported by the Beijing Ten Million Talent Plan Project (No. 2019A31), Research and Transformation of Clinical Diagnosis and Treatment Technology in Beijing (Z211100002921020), Gansu Provincial Science and Technology Program Subsidized Projects (21JRIRG303), and Young Doctor Scholar Project (2022).…”