Clinical features and therapeutic outcomes of patients with papillary thyroid microcarcinomas and larger tumors

Zheng, Wei; Wang, Xuan; Rui, Zhongying; Wang, Yi; Meng, Zhaowei; Wang, Renfei

doi:10.1097/mnm.0000000000000991

Cited by 11 publications

(10 citation statements)

References 35 publications

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“…In a meta-analysis including 6,839 PTMC patients, Yi et al found a recurrence rate of 2.8% 11 , very similar to ours. As we know, PTMCs are less aggressive 12 and most thyroid nodules < 1 cm should not undergo fine-needle aspiration (FNA). Furthermore, most of our patients (83.9%) had asymptomatic or incidental PTC which demonstrate a much lower recurrence rate than symptomatic or nonincidental tumours 13 .…”

Section: Discussionmentioning

confidence: 99%

Predictive factors for recurrence of papillary thyroid carcinoma: analysis of 4,085 patients

Carvalho

Köhler

Gomes

et al. 2021

Acta Otorhinolaryngol Ital

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Objective. The incidence of papillary thyroid carcinoma (PTC) has increased in recent years and its treatment remains controversial. The objective of this study is to identify clinicopathological predictive factors of tumour recurrence. Methods. We retrospectively analysed 4,085 patients who underwent thyroidectomy for PTC from 1996 to 2015. Patients were stratified according to American Thyroid Association (ATA) risk categories and clinicopathological features were evaluated to identify independent factors for recurrence. Results. After a mean follow-up of 58.7 (range 3-256.5) months, tumour recurrence was diagnosed in 176 (4.3%) patients, mostly in lymph nodes. Distant metastasis occurred in 18 patients (0.4%). There were 3 (0.1%) cancer-related deaths. Multivariate analysis showed that tumour size >10 mm, multifocality, extrathyroidal extension and lymph node metastasis (all, P < 0.001) were independent risk factors for recurrence. Further, recurrence was identified in 1.6% of the ATA low-risk, 7.4% of the intermediate-risk and 22.7% of the high-risk patients (P < 0.001). Conclusions. In PTC patients, tumour size >10 mm, multifocality, extrathyroidal extension and presence of lymph node metastasis as well as the ATA recurrence staging system effectively predict recurrence.

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Section: Discussionmentioning

confidence: 99%

Predictive factors for recurrence of papillary thyroid carcinoma: analysis of 4,085 patients

Carvalho

Köhler

Gomes

et al. 2021

Acta Otorhinolaryngol Ital

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“…Despite the increasing incidence of PTMC, it is indolent in nature, with patients usually having favorable prognosis [ 10 ]. However, a considerable subset of patients with PTMC have a tendency to develop aggressive disease and lymph node metastasis (LNM) [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Cervical Lymph Node Metastasis in Middle Eastern Papillary Thyroid Microcarcinoma

Parvathareddy

Siraj

Annaiyappanaidu

et al. 2022

JCM

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Papillary thyroid microcarcinoma (PTMC) typically has an indolent course and excellent prognosis. Nonetheless, a subset of PTMC carries a risk of lymph node metastasis (LNM) and local recurrence. PTC from the Middle Eastern population is unique with respect to demographic and clinico-pathological characteristics as compared to other ethnicities of the world. The risk factors of LNM in PTMC patients of Middle Eastern ethnicity have not been fully explored. The present study aims to investigate the influencing factors of LNM in Middle Eastern PTMC patients and its predictive impact on patient’s outcome. A total of 226 confirmed PTMC cases were selected in this retrospective study. The correlation between clinico-pathological, as well as molecular, characteristics and LNM was evaluated. Multivariate analysis was performed by logistic regression and Cox proportional hazards models. Among the 226 patients, the rate of LNM was 43.8% (99/226). Bilaterality, multifocality, gross extrathyroidal extension (ETE), and intermediate-to-high American Thyroid Association (ATA) risk tumors were significantly associated with LNM in PTMC. Multivariate logistic regression analysis showed that bilaterality and gross ETE were independent predictive factors for LNM in PTMC. The recurrence-free survival (RFS) was shorter in PTMC with LNM compared to those without LNM (p = 0.0051) and was significant on multivariate analysis. In conclusion, our study showed that bilaterality and gross ETE were independent influencing factors of LNM in Saudi patients with PTMC. LNM was also associated with shorter RFS. The identification of risk factors for LNM in patients of Middle Eastern ethnicity could help the individualization of clinical management for PTMC patients.

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“…The progress of PTMC is slow, but there is a corresponding risk of recurrence, distant metastasis and death, and young patients are more aggressive, especially in patients with lymph node metastasis. [ 16 ] Therefore, early and timely diagnosis is very important. Ultrasound examination is convenient, efficient and cheap, and its detection rate of thyroid diseases is significantly better than CT, MRI and radionuclide examination, etc.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of routine ultrasonography combined with ultrasound elastography for papillary thyroid microcarcinoma

Du¹,

Jiang²,

Tang³

et al. 2021

Medicine

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Background: Papillary thyroid microcarcinoma is easy to be missed because of its small focus, concealed incidence and lack of clinical features. Ultrasound examination is one of the main methods for the detection and diagnosis of papillary thyroid microcarcinoma. The detection rate of conventional ultrasound is not ideal. Combined ultrasound elastography can improve the detection rate, but there is lack of evidence-based evidence. The purpose of this study was to systematically evaluate the value of conventional ultrasound combined with ultrasound elastography in the diagnosis of papillary thyroid microcarcinoma. Methods: A systematic search was performed by retrieving on English databases (PubMed, Embase, Web of Science, the Cochrane Library) and Chinese databases (CNKI, Wanfang, Weipu (VIP), CBM). The retrieval time limit was from the establishment of the database to November 2020 and manually search for the conventional ultrasound combined with ultrasound elastography in the diagnosis of papillary thyroid microcarcinoma. Two researchers extracted and evaluated the quality of the data in the included study independently. A meta-analysis was performed using Meta Disc1.4 and RevMan5.3 software. Conclusions: This study will evaluate the accuracy and practicability of conventional ultrasound combined with ultrasonic elastography in the diagnosis of papillary thyroid microcarcinoma, and provide evidence-based basis for clinicians to choose the appropriate or best diagnostic method. Ethics and dissemination: The private information from individuals will not be published. This systematic review also will not involve endangering participant rights. Ethical approval is not required. OSF Registration number: DOI: 10.17605 / OSF.IO / V6HK7.

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Clinical features and therapeutic outcomes of patients with papillary thyroid microcarcinomas and larger tumors

Cited by 11 publications

References 35 publications

Predictive factors for recurrence of papillary thyroid carcinoma: analysis of 4,085 patients

Predictive factors for recurrence of papillary thyroid carcinoma: analysis of 4,085 patients

Risk Factors for Cervical Lymph Node Metastasis in Middle Eastern Papillary Thyroid Microcarcinoma

Diagnostic value of routine ultrasonography combined with ultrasound elastography for papillary thyroid microcarcinoma

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