Clinical features and treatment of Malassezia folliculitis with fluconazole in orthotopic heart transplant recipients

Rhie, Sangho; Turcios, Rosa; Buckley, Helen R.; Suh, Byungse

doi:10.1016/s1053-2498(99)00123-0

Cited by 55 publications

(31 citation statements)

References 12 publications

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“…M. sympodialis was found on mycological examination of the folliculitis lesions of renal cell carcinoma patients who underwent treatment with erlotinib, an anticancer agent 33 , and this further increases the possibility of this strain being pathogenic. However, considering that there have been reports, such as those by Crespo and Delgado 6 and Rhie et al 34 , that the main causative agents of Malassezia folliculitis are normal flora of the skin other than M. sympodialis, and that other strains such as M. furfur, had been isolated from the neonatal Malassezia folliculitis lesions on the face 3 , and given the outcome of this study in which the rate of identifying M. sympodialis in the twenties control group was lower than that in the patient group, the possibility of this strain being pathogenic may be questioned. Therefore, in order to identify the Malassezia species that play a major role in the pathogenesis and aggravation of Malassezia folliculitis, a large-scale quantitative analysis in future studies conducted on a larger patient pool and more variable sites of lesions may be needed.…”

Section: Discussionmentioning

confidence: 94%

Epidemiologic Study ofMalasseziaYeasts in Patients withMalasseziaFolliculitis by 26S rDNA PCR-RFLP Analysis

Lee

Choe

et al. 2011

Ann Dermatol

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Background:So far, studies on the inter-relationship between Malassezia and Malassezia folliculitis have been rather scarce. Objective: We sought to analyze the differences in body sites, gender and age groups, and to determine whether there is a relationship between certain types of Malassezia species and Malassezia folliculitis. Methods: Specimens were taken from the forehead, cheek and chest of 60 patients with Malassezia folliculitis and from the normal skin of 60 age-and gender-matched healthy controls by 26S rDNA PCR-RFLP. Results: M. restricta was dominant in the patients with Malassezia folliculitis (20.6%), while M. globosa was the most common species (26.7%) in the controls. The rate of identification was the highest in the teens for the patient group, whereas it was the highest in the thirties for the control group. M. globosa was the most predominant species on the chest with 13 cases (21.7%), and M. restricta was the most commonly identified species, with 17 (28.3%) and 12 (20%) cases on the forehead and cheek, respectively, for the patient group. Conclusion: Statistically significant differences were observed between the patient and control groups for the people in their teens and twenties, and in terms of the body site, on the forehead only. (Ann Dermatol 23(2) 177∼184, 2011)

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Section: Discussionmentioning

confidence: 94%

Epidemiologic Study ofMalasseziaYeasts in Patients withMalasseziaFolliculitis by 26S rDNA PCR-RFLP Analysis

Lee

Choe

et al. 2011

Ann Dermatol

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“…It was first reported by Weary et al (460) in the setting of antibiotic therapy and has also been seen in association with pregnancy (188), leukaemia (483), bone marrow transplantation (74), AIDS (142), Down's syndrome (212), Hodgkin's disease (184), diabetes (20,340) and kidney (450) and heart (357) transplantation. Because folliculitis is frequently seen in immunocompromised patients, the importance of differentiating it from lesions of systemic fungal infection has been stressed (225).…”

Section: Malassezia Folliculitismentioning

confidence: 95%

Immunology of Diseases Associated withMalasseziaSpecies

2002

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SUMMARY Malassezia species are members of the human cutaneous commensal flora, in addition to causing a wide range of cutaneous and systemic diseases in suitably predisposed individuals. Studies examining cellular and humoral immune responses specific to Malassezia species in patients with Malassezia-associated diseases and healthy controls have generally been unable to define significant differences in their immune response. The use of varied antigenic preparations and strains from different Malassezia classifications may partly be responsible for this, although these problems can now be overcome by using techniques based on recent work defining some important antigens and also a new taxonomy for the genus. The finding that the genus Malassezia is immunomodulatory is important in understanding its ability to cause disease. Stimulation of the reticuloendothelial system and activation of the complement cascade contrasts with its ability to suppress cytokine release and downregulate phagocytic uptake and killing. The lipid-rich layer around the yeast appears to be pivotal in this alteration of phenotype. Defining the nonspecific immune response to Malassezia species and the way in which the organisms modulate it may well be the key to understanding how Malassezia species can exist as both commensals and pathogens.

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“…5). Oc-clusion is a common predisposing factor (18), especially for susceptible individuals (126), and the condition is also associated with immunosuppression (8,226,263); however, in these patients, it may appear with less distinct pruritus (65). Histopathological sections reveal dilated, partly destructed hair follicles, which contain keratinous material, debris, and, sometimes, mucin.…”

Section: Malassezia Folliculitismentioning

confidence: 99%

“…Thus, because of clinical similarities, this condition might be underdiagnosed in patients with acne (16). Also, Malassezia folliculitis in the form of an epidemic in an intensive care setting (12) and in heart transplant recipients (263) has been reported. However, it is rather rare in pregnancy (186), despite the corresponding relative immunosuppression.…”

Section: Malassezia Folliculitismentioning

confidence: 99%

The Malassezia Genus in Skin and Systemic Diseases

et al. 2012

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SUMMARY In the last 15 years, the genus Malassezia has been a topic of intense basic research on taxonomy, physiology, biochemistry, ecology, immunology, and metabolomics. Currently, the genus encompasses 14 species. The 1996 revision of the genus resulted in seven accepted taxa: M. furfur , M. pachydermatis , M. sympodialis , M. globosa , M. obtusa , M. restricta , and M. slooffiae. In the last decade, seven new taxa isolated from healthy and lesional human and animal skin have been accepted: M. dermatis , M. japonica , M. yamatoensis , M. nana , M. caprae , M. equina , and M. cuniculi. However, forthcoming multidisciplinary research is expected to show the etiopathological relationships between these new species and skin diseases. Hitherto, basic and clinical research has established etiological links between Malassezia yeasts, pityriasis versicolor, and sepsis of neonates and immunocompromised individuals. Their role in aggravating seborrheic dermatitis, dandruff, folliculitis, and onychomycosis, though often supported by histopathological evidence and favorable antifungal therapeutic outcomes, remains under investigation. A close association between skin and Malassezia IgE binding allergens in atopic eczema has been shown, while laboratory data support a role in psoriasis exacerbations. Finally, metabolomic research resulted in the proposal of a hypothesis on the contribution of Malassezia -synthesized aryl hydrocarbon receptor (AhR) ligands to basal cell carcinoma through UV radiation-induced carcinogenesis.

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Clinical features and treatment of Malassezia folliculitis with fluconazole in orthotopic heart transplant recipients

Cited by 55 publications

References 12 publications

Epidemiologic Study ofMalasseziaYeasts in Patients withMalasseziaFolliculitis by 26S rDNA PCR-RFLP Analysis

Epidemiologic Study ofMalasseziaYeasts in Patients withMalasseziaFolliculitis by 26S rDNA PCR-RFLP Analysis

Immunology of Diseases Associated withMalasseziaSpecies

The Malassezia Genus in Skin and Systemic Diseases

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