Clinical features and treatment of overdosage of monoamine oxidase inhibitors and their interaction with other psychotropic drugs

Tranylcypromine (‘Parnate’) overdose: measurement of tranylcypromine concentrations and MAO inhibitory activity and identification of amphetamines in plasma

“…The clinical syndrome shown by our patient was similar to that which has been described by previous observers (Matter et al 1965;Mawdsley, 1968;Coulter et al 1971;Ciocatto et al 1972;Robertson, 1972;Griffiths, 1973;Shepherd & Whiting, 1974). The finding of amphetamines and phenylethylamine in the plasma suggests that some, if not all, of the signs and symptoms of tranylcypromine overdose may be due either to amphetamines (Espelin & Done, 1968;Ginsberg et al 1970) or to phenylethylamine which has similar effects to amphetamine in animals (Borison et al 1977).…”

The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: Old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension

“…Compound Co TH9 known as phenelzine (Sold as Nardil ® ) is a potent, irreversible inhibitor of monoamine oxidase (MAO)-A and -B that has been used to treat depression since the late 1950s [30]. Phenelzine toxicity is normally characterised by agitation, seizures, sweating, tachycardia and hypertension [31][32][33], Fig. 9.…”

Emergency Management of Hypertension in Children

“…Hypertensive crisis is also known to occur when medications like monoamine oxidase inhibitors interact with food containing tyramine and other medications like dextromethorphan, methylene blue, selective serotonin reuptake inhibitors, and linezolid. Hypertension due to MAOI interaction can be treated with either an alpha blocker or sodium nitroprusside [88–91]. Hypertensive crisis due to amphetamine toxicity is due to sympathomimetic and serotonergic effects of amphetamines.…”